AIRE gene

Known as: Autoimmune Regulator Gene, AUTOIMMUNE REGULATOR, autoimmune polyendocrinopathy candidiasis ectodermal dystrophy 
This gene is involved in both self-tolerance and the positive regulation of transcription.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1935-2018
0204019352017

Papers overview

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Highly Cited
2010
Highly Cited
2010
Aire induces the expression of a battery of peripheral-tissue self-antigens (PTAs) in thymic stromal cells, promoting the clonal… (More)
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Highly Cited
2007
Highly Cited
2007
Aire-expressing medullary thymic epithelial cells (mTECs) play a key role in preventing autoimmunity by expressing tissue… (More)
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Highly Cited
2007
Highly Cited
2007
Expression of autoimmune regulator (Aire) by thymic medullary epithelial cells (MECs) is critical for central tolerance of self… (More)
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Highly Cited
2005
Highly Cited
2005
Aire promotes the tolerization of thymocytes by inducing the expression of a battery of peripheral-tissue antigens in thymic… (More)
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Highly Cited
2004
Highly Cited
2004
Inactivation of the autoimmune regulator (Aire) gene causes a rare recessive disorder, autoimmune polyendocrine syndrome 1 (APS1… (More)
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Highly Cited
2003
Highly Cited
2003
Autoimmune polyendocrinopathy syndrome type 1 is a recessive Mendelian disorder resulting from mutations in a novel gene, AIRE… (More)
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Highly Cited
2003
Highly Cited
2003
The autoimmune regulator Aire is a key mediator of central tolerance for peripherally restricted antigens. Its absence in human… (More)
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Highly Cited
2002
Highly Cited
2002
Humans expressing a defective form of the transcription factor AIRE (autoimmune regulator) develop multiorgan autoimmune disease… (More)
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Highly Cited
2002
Highly Cited
2002
Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a monogenic autosomal recessive disease caused by… (More)
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Highly Cited
1997
Highly Cited
1997
Autoimmune polyglandular syndrome type I (APS 1, also called APECED) is an autosomal-recessive disorder that maps to human… (More)
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