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Ligand‐regulated transport of the Menkes copper P‐type ATPase efflux pump from the Golgi apparatus to the plasma membrane: a novel mechanism of regulated trafficking.
The Menkes P‐type ATPase (MNK), encoded by the Menkes gene (MNK; ATP7A), is a transmembrane copper‐translocating pump which is defective in the human disorder of copper metabolism, Menkes disease.Expand
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C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking
Department of Biochemistry, Department of Neuroscience, School of Psychological Science, La Trobe University, Victoria, Australia, Australian School of Advanced Medicine, Macquarie University,Expand
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Macropinocytosis: an endocytic pathway for internalising large gulps
Macropinocytosis is a regulated form of endocytosis that mediates the non‐selective uptake of solute molecules, nutrients and antigens. It is an actin‐dependent process initiated from surfaceExpand
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C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking
Intronic expansion of a hexanucleotide GGGGCC repeat in the chromosome 9 open reading frame 72 (C9ORF72) gene is the major cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporalExpand
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The golgin GCC88 is required for efficient retrograde transport of cargo from the early endosomes to the trans-Golgi network.
Retrograde transport pathways from early/recycling endosomes to the trans-Golgi network (TGN) are poorly defined. We have investigated the role of TGN golgins in retrograde trafficking. Of the fourExpand
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Visualisation of macropinosome maturation by the recruitment of sorting nexins
We report that phosphoinositol-binding sorting nexin 5 (SNX5) associates with newly formed macropinosomes induced by EGF stimulation. We used the recruitment of GFP-SNX5 to macropinosomes to trackExpand
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New insights into membrane trafficking and protein sorting.
Protein transport in the secretory and endocytic pathways is a multistep process involving the generation of transport carriers loaded with defined sets of cargo, the shipment of the cargo-loadedExpand
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A novel Golgi-localisation domain shared by a class of coiled-coil peripheral membrane proteins
The mechanism by which peripheral membrane proteins are targeted to the cytoplasmic face of the Golgi apparatus is poorly understood. Previously, we have identified a carboxy-terminal domain of theExpand
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The trans‐Golgi Network Golgin, GCC185, is Required for Endosome‐to‐Golgi Transport and Maintenance of Golgi Structure
Four mammalian golgins are specifically targeted to the trans‐Golgi network (TGN) membranes via their C‐terminal GRIP domains. The TGN golgins, p230/golgin‐245 and golgin‐97, are recruited via theExpand
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E‐Cadherin Transport from the trans‐Golgi Network in Tubulovesicular Carriers is Selectively Regulated by Golgin‐97
E‐cadherin is a cell–cell adhesion protein that is trafficked and delivered to the basolateral cell surface. Membrane‐bound carriers for the post‐Golgi exocytosis of E‐cadherin have not beenExpand
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