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AIRE protein, human

Known as: AIRE1 protein, human, APECED protein, human, PGA1 protein, human 
Autoimmune regulator (545 aa, ~58 kDa) is encoded by the human AIRE gene. This protein is involved in both the activation of gene transcription and… 
National Institutes of Health

Related topics

Related topics

11 relations
AIRE geneDNA-Binding ProteinsGenes, RegulatorImmune Tolerance

Broader (1)

APECED protein

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
FBXO3 Protein Promotes Ubiquitylation and Transcriptional Activity of AIRE (Autoimmune Regulator)*
The autoimmune regulator (AIRE) is a transcription factor which is expressed in medullary thymic epithelial cells. It directs the… 
2011
2011
APSI-BASED DELIBERATION IN GOAL ORIENTED AUTONOMOUS CONTROLLERS
This paper describes a timeline-based, domain independent deliberative layer, based on E SA APSI technology, deployed in the… 
Highly Cited
2010
Highly Cited
2010
Human peripheral lymphoid tissues contain autoimmune regulator-expressing dendritic cells.
Autoimmune regulator (AIRE) modulates the expression of tissue-restricted antigens (TSAs) and promotes central tolerance in the… 
Highly Cited
2009
Highly Cited
2009
Aire-Deficient C57BL/6 Mice Mimicking the Common Human 13-Base Pair Deletion Mutation Present with Only a Mild Autoimmune Phenotype1
Autoimmune regulator (AIRE) is an important transcription regulator that mediates a role in central tolerance via promoting the… 
Highly Cited
2009
Highly Cited
2009
Structure and site-specific recognition of histone H3 by the PHD finger of human autoimmune regulator.
Highly Cited
2006
Highly Cited
2006
Increased antigen presenting cell‐mediated T cell activation in mice and patients without the autoimmune regulator
Patients with autoimmune polyendocrine syndrome type I (APS I)suffer from endocrine and non‐endocrine disorders due to mutations… 
Highly Cited
2005
Highly Cited
2005
Cooperative activation of transcription by autoimmune regulator AIRE and CBP.
Highly Cited
2004
Highly Cited
2004
Subcellular Expression of Autoimmune Regulator Is Organized in a Spatiotemporal Manner*
Autoimmune regulator (AIRE) is responsible for the development of organ-specific autoimmune disease in a monogenic fashion. Rare… 
Highly Cited
2002
Highly Cited
2002
Systematic mutagenesis of the functional domains of AIRE reveals their role in intracellular targeting.
Mutations in the human autoimmune regulator (AIRE ) gene cause a multi-systemic autoimmune syndrome that is known as autoimmune… 
1998
1998
6 Autoimmune polyglandular syndromes
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