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Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin
TLDR
It is shown that the astrocytic dopamine D2 receptor (DRD2) modulates innate immunity through αB-crystallin (CRYAB), which is known to suppress neuroinflammation in the central nervous system through a CRYAB-dependent mechanism. Expand
Expanding roles for SREBP in metabolism.
TLDR
Sterol regulatory element-binding protein (SREBP) transcription factors regulate cellular lipogenesis and lipid homeostasis and the discovery of functions for SREBPs in type II diabetes, cancer, immunity, neuroprotection, and autophagy is revealed. Expand
Small Molecule Antagonizes Autoinhibition and Activates AMP-activated Protein Kinase in Cells*
TLDR
PT1 highlights the effort to discover novel AMPK activators and can be a useful tool for elucidating the mechanism responsible for conformational change and autoinhibitory regulation of AMPK. Expand
Cortical neurogenesis in the absence of centrioles
TLDR
The functions of centrioles in anchoring RGPs in the VZ and ensuring their efficient mitoses are defined and revealed, and the robust adaptability of RGPs is revealed in the developing cortex. Expand
Juvenile hormone counteracts the bHLH-PAS transcription factors MET and GCE to prevent caspase-dependent programmed cell death in Drosophila
TLDR
It is demonstrated that JH counteracts MET and GCE to prevent caspase-dependent PCD in controlling fat body remodeling and larval-pupal metamorphosis in Drosophila. Expand
The Caspase-1 Digestome Identifies the Glycolysis Pathway as a Target during Infection and Septic Shock*♦
TLDR
The systematic characterization of caspase-1 substrates identifies the glycolysis pathway as a caspite-1 target and provides new insights into its function during pyroptosis and septic shock. Expand
A Modifier Screen for Bazooka/PAR-3 Interacting Genes in the Drosophila Embryo Epithelium
TLDR
The enhancer screen identified 17 genes that function with Baz to regulate epithelial structure in the Drosophila embryo and indicated that some of the proteins may affect epithelial cell polarity by acting at the apical cell cortex while others may act through intracellular processes. Expand
SDCCAG8 Regulates Pericentriolar Material Recruitment and Neuronal Migration in the Developing Cortex
TLDR
It is shown that SDCCAG8 regulates centrosomal accumulation of pericentriolar material and neuronal polarization and migration in the developing mouse cortex and provides insights into the basis of neurological defects linked to SD CCAG8 mutations. Expand
Sterol Regulatory Element-binding Protein (SREBP) Cleavage Regulates Golgi-to-Endoplasmic Reticulum Recycling of SREBP Cleavage-activating Protein (SCAP)*
TLDR
SREBP regulates SCAP in human cells and yeast, indicating that this is an ancient regulatory mechanism, and it is demonstrated that SCAP Golgi-to-ER transport requires cleavage of SREBP at site-1. Expand
A U1-U2 snRNP Interaction Network during Intron Definition
TLDR
This work describes the protein network of interactions linking U1 and U2 snRNPs with the ATPase Prp5, important for branch site recognition and fidelity during the first steps of the reaction, using fission yeast Schizosaccharomyces pombe to indicate that the U1-U2 network provides critical, evolutionarily conserved contacts during intron definition. Expand
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