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  • S. Sakaguchi, N. Sakaguchi, M. Asano, M. Itoh, M. Toda
  • Biology, Chemistry, Medicine
  • Journal of immunology
  • 1995 (First Publication: 1 August 1995)
  • Approximately 10% of peripheral CD4+ cells and less than 1% of CD8+ cells in normal unimmunized adult mice express the IL-2 receptor alpha-chain (CD25) molecules. When CD4+ cell suspensions preparedExpand
  • T. Takahashi, Tomoyuki Tagami, +5 authors S. Sakaguchi
  • Medicine, Biology
  • The Journal of experimental medicine
  • 2000 (First Publication: 17 July 2000)
  • This report shows that cytotoxic T lymphocyte–associated antigen 4 (CTLA-4) plays a key role in T cell–mediated dominant immunologic self-tolerance. In vivo blockade of CTLA-4 for a limited period inExpand