Share This Author
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
Foxp3, which encodes a transcription factor that is genetically defective in an autoimmune and inflammatory syndrome in humans and mice, is specifically expressed in naturally arising CD4+ regulatory T cells and retroviral gene transfer of Foxp3 converts naïve T cells toward a regulatory T cell phenotype similar to that of naturally occurring CD4+.
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.
- S. Sakaguchi, N. Sakaguchi, M. Asano, M. Itoh, M. Toda
- Biology, MedicineJournal of Immunology
- 1 August 1995
Results indicate that CD4+CD25+ cells contribute to maintaining self-tolerance by down-regulating immune response to self and non-self Ags in an Ag-nonspecific manner, presumably at the T cell activation stage, thereby not only enhancing immune responses to non- self Ags, but also eliciting autoimmune responses to certain self-Ags.
Regulatory T Cells and Immune Tolerance
Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses.
- S. Sakaguchi
- Biology, MedicineAnnual Review of Immunology
- 19 March 2004
How naturally arising CD25+CD4+ regulatory T cells contribute to the maintenance of immunologic self-tolerance and negative control of various immune responses, and how they can be exploited to prevent and treat autoimmune disease, allergy, cancer, and chronic infection, or establish donor-specific transplantation tolerance are discussed.
CTLA-4 Control over Foxp3+ Regulatory T Cell Function
It is shown that a specific deficiency of cytotoxic T lymphocyte antigen 4 (CTLA-4) in Tregs results in spontaneous development of systemic lymphoproliferation, fatal T cell–mediated autoimmune disease, and hyperproduction of immunoglobulin E in mice.
Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor.
Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance
- J. Shimizu, S. Yamazaki, Takeshi Takahashi, Y. Ishida, S. Sakaguchi
- Biology, MedicineNature Immunology
- 1 February 2002
GITR plays a key role in dominant immunological self-tolerance maintained by CD25+CD4+ regulatory T cells and could be a suitable molecular target for preventing or treating autoimmune disease.
Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self
- S. Sakaguchi
- BiologyNature Immunology
- 1 April 2005
Naturally arising CD25+CD4+ regulatory T cells actively maintain immunological self-tolerance, and are a good target for designing ways to induce or abrogate immunological tolerance to self and non-self antigens.
FOXP3+ regulatory T cells in the human immune system
Recent findings regarding human TReg cells are discussed, including the ontogeny and development of TReg cell subsets that have naive or memory phenotypes, the unique mechanisms of suppression mediated by TRegcell subsets and factors that regulateTReg cell lineage commitment.
Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota
Using a rational approach to isolate CD4+FOXP3+ regulatory T (Treg)-cell-inducing bacterial strains from the human indigenous microbiota may allow for tailored therapeutic manipulation of human immune disorders.