Skip to search formSkip to main contentSkip to account menu

AF-4 protein

Known as: Trithorax Homolog 2, Protein AF-4, MLLT2 
AF4/FMR2 family member 1 (1210 aa, ~131 kDa) is encoded by the human AFF1 gene. This protein may be involved in the regulation of transcription.
National Institutes of Health

Related topics

Related topics

10 relations
AF5q31 proteinAFF1 geneAFF1 wt AlleleAFF4 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Detection and characterization of silver nanoparticles in chicken meat by asymmetric flow field flow fractionation with detection by conventional or single particle ICP-MS
A method of analysis of silver nanoparticles (AgNPs) in chicken meat was developed. The homogenized chicken meat sample, which… 
Review
2013
Review
2013
Flow field-flow fractionation: critical overview.
Highly Cited
2012
Highly Cited
2012
A Genome-Wide Association Study Identified AFF1 as a Susceptibility Locus for Systemic Lupus Eyrthematosus in Japanese
Systemic lupus erythematosus (SLE) is an autoimmune disease that causes multiple organ damage. Although recent genome-wide… 
Highly Cited
2005
Highly Cited
2005
The eleven-nineteen-leukemia protein ENL connects nuclear MLL fusion partners with chromatin
Mixed lineage leukemia (MLL) fusion proteins are derived from translocations at 11q23 that occur in aggressive subtypes of… 
Highly Cited
2004
Highly Cited
2004
MLL fusion partners AF4 and AF9 interact at subnuclear foci
The MLL gene is involved in translocations associated with both acute lymphoblastic and acute myelogenous leukemia. These… 
Highly Cited
1999
Highly Cited
1999
AF5q31, a newly identified AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia with ins(5;11)(q31;q13q23).
Infant acute lymphoblastic leukemia (ALL) with MLL gene rearrangements is characterized by early pre-B phenotype (CD10(-)/CD19… 
Highly Cited
1998
Highly Cited
1998
Immunotherapy with Fel d 1 peptides decreases IL-4 release by peripheral blood T cells of patients allergic to cats.
Highly Cited
1995
Highly Cited
1995
Domains with transcriptional regulatory activity within the ALL1 and AF4 proteins involved in acute leukemia.
The ALLI gene, located at chromosome band 11q23, is involved in acute leukemia through a series of chromosome translocations and… 
Highly Cited
1993
Highly Cited
1993
Peripheral T-cell tolerance induced in naive and primed mice by subcutaneous injection of peptides from the major cat allergen Fel d I.
T cells control the majority of antigen-specific immune responses. Therefore, influencing the activation of the T-cell response… 
Highly Cited
1993
Highly Cited
1993
Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product.
A chromosomal translocation, t(4;11)-(q21;q23), is associated with an aggressive mixed-lineage leukemia. A yeast artificial… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)