Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses
- Katherine B. Chiappinelli, P. Strissel, R. Strick
- BiologyCell
- 27 August 2015
Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses
- Katherine B. Chiappinelli, P. Strissel, R. Strick
- BiologyCell
- 25 February 2016
Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemia.
- R. Strick, P. Strissel, S. Borgers, S. Smith, J. Rowley
- BiologyProceedings of the National Academy of Sciences…
- 25 April 2000
The results suggest that maternal ingestion of bioflavonoids may induce MLL breaks and potentially translocations in utero leading to infant and early childhood leukemia.
High incidence of recurrent copy number variants in patients with isolated and syndromic Müllerian aplasia
- S. Nik-Zainal, R. Strick, C. Shaw-Smith
- MedicineJournal of Medical Genetics
- 28 January 2011
The finding of microdeletion at 16p11.2 in 2/38 (5%) of isolated and 2/25 (8%) of syndromic cases suggests a significant contribution of this copy number variant alone to the pathogenesis of Müllerian aplasia.
Recurrent aberrations identified by array-CGH in patients with Mayer-Rokitansky-Küster-Hauser syndrome.
- S. Ledig, C. Schippert, R. Strick, M. Beckmann, P. Oppelt, P. Wieacker
- MedicineFertility and Sterility
- 1 April 2011
DNA structural properties of AF9 are similar to MLL and could act as recombination hot spots resulting in MLL/AF9 translocations and leukemogenesis.
- P. Strissel, R. Strick, R. Tomek, B. Roe, J. Rowley, N. Zeleznik-Le
- BiologyHuman Molecular Genetics
- 1 July 2000
A DNA breakage and repair model for non-homologous recombination between MLL and its partner genes, particularly AF9 is described and it is demonstrated that the patient breakpoint regions of AF9 share the same structural elements as the MLL BCR.
Clinical aspects of Mayer-Rokitansky-Kuester-Hauser syndrome: recommendations for clinical diagnosis and staging.
- P. Oppelt, S. Renner, M. Beckmann
- MedicineHuman Reproduction
- 1 March 2006
It is shown that associated malformations are present in more than a third of cases and new basic guidelines for standard diagnostic classification involving patients with suspected MRKH are presented.
Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen.
- W. Schroth, M. Goetz, H. Brauch
- Medicine, BiologyJAMA
- 7 October 2009
Among women with breast cancer treated with tamoxifen, there was an association between CYP2D6 variation and clinical outcomes, such that the presence of 2 functional CYP 2D6 alleles was associated with better clinical outcomes and the absence of nonfunctional or reduced-function alleles with worse outcomes.
Cation–chromatin binding as shown by ion microscopy is essential for the structural integrity of chromosomes
- R. Strick, P. Strissel, K. Gavrilov, R. Levi‐Setti
- BiologyJournal of Cell Biology
- 10 December 2001
The Ca2+-induced inhibition of Topo II catalytic activity and direct binding of Ca2+, Mg2+, Na+, and K+ in higher order chromosome structure through electrostatic neutralization and a functional interaction with nonhistone proteins supports a regulatory role ofCa2+ during mitosis in promoting solely the structural function of TopO II.
Angiogenic growth factors in maternal and fetal serum in pregnancies complicated by intrauterine growth restriction.
- W. Wallner, R. Sengenberger, D. Schlembach
- Medicine, BiologyClinical science
- 2007
The findings suggest an imbalance of angiogenic and anti-angiogenic factors in IUGR, with formation of an anti-Angiogenic state in maternal and, to a lesser extent, umbilical vein blood.
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