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Physiological functions of glucocorticoids in stress and their relation to pharmacological actions.
TLDR
It is proposed that stress-induced increases in glucocorticoid levels protect not against the source of stress itself but rather against the body's normal reactions to stress, preventing those reactions from overshooting and themselves threatening homeostasis.
A novel polymorphism of FcgammaRIIIa (CD16) alters receptor function and predisposes to autoimmune disease.
TLDR
Initial analysis of 200 patients with SLE indicates a strong association of the low binding phenotype with disease, especially in patients with nephritis who have an underrepresentation of the homozygous high binding phenotype.
Human monocytes express CD163, which is upregulated by IL-10 and identical to p155.
TLDR
It is shown that >99% of all CD14 positive monocytes express CD163 and that monocyte derived dendritic cells express low levels of CD163, and that IL-10, like glucocorticoid-inducible member of the scavenger receptor cysteine-rich family of proteins, induces high CD163 expression on cultured human monocytes.
Type I (CD64) and type II (CD32) Fc gamma receptor-mediated phagocytosis by human blood dendritic cells.
TLDR
Results indicate that both CD64 and CD32 expressed on blood dendritic cells may play a role in uptake of foreign particles and macromolecules through a phagocytic mechanism before trafficking to T cell-reactive areas.
Endotoxin induces rapid metalloproteinase‐mediated shedding followed by up‐regulation of the monocyte hemoglobin scavenger receptor CD163
TLDR
It is shown that CD163 is rapidly mobilized in response to bacterial endotoxin, and studies using the inhibitor TAPI‐0 indicate that a metalloproteinase is responsible for LPS‐mediated shedding of CD163.
Bispecific antibodies.
TLDR
The limited clinical trials that have occurred to date suggest that BsAb may offer considerable promise for therapeutic applications, including cancer, heart disease, infectious disease, allergy, and autoimmunity.
IFN-gamma is produced by polymorphonuclear neutrophils in human uterine endometrium and by cultured peripheral blood polymorphonuclear neutrophils.
TLDR
It is found that polymorphonuclear neutrophils isolated from normal donors produce IFN-gamma in response to stimulation with LPS, IL-12, and TNF-alpha, indicating that their role in shaping immune responses may be more extensive than previously thought.
Induction of MHC class II on human polymorphonuclear neutrophils by granulocyte/macrophage colony-stimulating factor, IFN-gamma, and IL-3.
TLDR
It is shown that, in the presence of a defined medium, human serum, and granulocyte-CSF, nearly 100% of isolated PMN can survive for up to 2 days in vitro and express MHC class II, and the potential to express class II suggests that PMN could play a significant role in immunoregulation and disease pathogenesis.
Recombinant immune interferon increases immunoglobulin G Fc receptors on cultured human mononuclear phagocytes.
TLDR
It is demonstrated that gamma-interferon acts directly on human mononuclear phagocytes to increase FcR gamma sites, a qualitative difference in the physiologic actions of human type I and type II interferons is identified, and it is suggested that HL-60 and U-937 cells will be important models for further study of the molecular mechanisms of interferon action.
Flow Cytometric Analysis of Leukocytes in the Human Female Reproductive Tract: Comparison of Fallopian Tube, Uterus, Cervix, and Vagina
TLDR
The purpose of this study was to develop a uniform method suitable for quantitative comparison of the leukocytes from all these tissues.
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