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Immunological mechanisms of allergen-specific immunotherapy
Allergen-specific immunotherapy has been carried out for almost a century and remains one of the few antigen-specific treatments for inflammatory diseases. The mechanisms by which allergen-specific… Expand
The role of T lymphocytes in the pathogenesis of asthma.
There is considerable evidence to support a role for T cells in asthma, particularly the involvement of T(H)2 cells both in atopic allergic asthma and in nonatopic and occupational asthma. There… Expand
Peptide-based therapeutic vaccines for allergic and autoimmune diseases
Allergic and autoimmune diseases are forms of immune hypersensitivity that increasingly cause chronic ill health. Most current therapies treat symptoms rather than addressing underlying immunological… Expand
Tregs and allergic disease.
Allergic diseases such as asthma, rhinitis, and eczema are increasing in prevalence and affect up to 15% of populations in Westernized countries. The description of Tregs as T cells that prevent… Expand
Peptide immunotherapy in allergic asthma generates IL-10–dependent immunological tolerance associated with linked epitope suppression
- J. D. Campbell, K. Buckland, +12 authors M. Larché
- Biology, Medicine
- The Journal of experimental medicine
- 6 July 2009
Treatment of patients with allergic asthma using low doses of peptides containing T cell epitopes from Fel d 1, the major cat allergen, reduces allergic sensitization and improves surrogate markers… Expand
Expression of IL-4 and IL-5 mRNA and protein product by CD4+ and CD8+ T cells, eosinophils, and mast cells in bronchial biopsies obtained from atopic and nonatopic (intrinsic) asthmatics.
We recently demonstrated bronchial mucosal expression of IL-4 and IL-5 at the mRNA and protein level in both atopic and nonatopic (intrinsic) asthma. In this report, using double immunohistochemistry… Expand
IL-5 secretion by allergen-stimulated CD4+ T cells in primary culture: relationship to expression of allergic disease.
- S. Till, R. Dickason, +6 authors C. Corrigan
- The Journal of allergy and clinical immunology
- 1 April 1997
BACKGROUND IL-5-producing allergen-specific T cells are thought to play a prominent role in the pathogenesis of allergic inflammation. We hypothesized that T cell allergen-driven IL-5 synthesis is… Expand
Functional rather than immunoreactive levels of IgG4 correlate closely with clinical response to grass pollen immunotherapy
To cite this article: Shamji MH, Ljørring C, Francis JN, Calderon MA, Larché M, Kimber I, Frew AJ, Ipsen H, Lund K, Würtzen PA, Durham SR. Functional rather than immunoreactive levels of IgG4… Expand
Regulatory T cells in allergy and asthma.
- M. Larché
- 1 September 2007
Allergic diseases including asthma have risen considerably in prevalence in the last 50 years. A concomitant rise in autoimmune disease suggests a defect in immunoregulation, rather than a reduction… Expand
Hyper IgM syndrome associated with defective CD40-mediated B cell activation.
- M. Conley, M. Larché, +6 authors D. Campana
- Biology, Medicine
- The Journal of clinical investigation
- 1 October 1994
Recent studies show that most patients with X-linked hyper IgM syndrome have defects in the gene for CD40 ligand. We evaluated 17 unrelated males suspected of having X-linked hyper IgM syndrome.… Expand