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CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1
TLDR
Southern blot analyses and genomic cloning demonstrates the existence of related genes, raising the possibility that similar abnormalities in related genes may give rise to diseases similar to Machado-Joseph disease.
Elotuzumab Therapy for Relapsed or Refractory Multiple Myeloma.
TLDR
Patients with relapsed or refractory multiple myeloma who received a combination of elotuzumab, lenalidomide, and dexamethasone had a significant relative reduction of 30% in the risk of disease progression or death.
Identification of a photoreceptor cell-specific nuclear receptor.
TLDR
The identification of a human nuclear receptor that reveals a unique proximal box (CNGCSG) in the DNA-binding domain suggests the requirement for this type of P box in the genetic cascades mediated by nuclear receptors in a wide variety of animal species.
Multicenter phase II study of mogamulizumab (KW-0761), a defucosylated anti-cc chemokine receptor 4 antibody, in patients with relapsed peripheral T-cell lymphoma and cutaneous T-cell lymphoma.
  • M. Ogura, T. Ishida, R. Ueda
  • Medicine, Biology
    Journal of clinical oncology : official journal…
  • 10 April 2014
TLDR
Mogamulizumab exhibited clinically meaningful antitumor activity in patients with relapsed PTCL and CTCL, with an acceptable toxicity profile, and further investigation of mogamulIZumab for treatment of T-cell lymphoma is warranted.
LCX, leukemia-associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23).
TLDR
The MLL gene on 11q23 was fused to the LCX (leukemia-associated protein with a CXXC domain) gene on 10q22 in a de novoadult AML-M2 with trilineage dysplasia having t(10;11)(q22;q23), which suggests that these fusion proteins are involved in the pathogenesis of 11Q23-associated leukemia through similar mechanisms.
Recurrent DUX4 fusions in B cell acute lymphoblastic leukemia of adolescents and young adults
TLDR
The data show that DUX4 can become an oncogenic driver as a result of somatic chromosomal rearrangements and that AYA-ALL may be a clinical entity distinct from ALL at other ages, and that Dux4 fusions were preferentially detected in the AYA generation.
A novel gene, MALT1 at 18q21, is involved in t(11;18) (q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue
TLDR
A novel cDNA spanning the breakpoint region that exhibited aberrant mRNA signals in four of the five MALT lymphoma patients was identified and predicted an 813 amino acid protein that shows significant sequence similarity to the CD22β and laminin 5 α3b subunit.
The Ig heavy chain gene is frequently involved in chromosomal translocations in multiple myeloma and plasma cell leukemia as detected by in situ hybridization.
TLDR
Findings indicate that 14q32.33 translocation with various partner chromosomes is a critical event in the pathogenesis of MM and MGUS, and closely associated with translocation of proto-oncogenes into the IgH gene.
AF5q31, a newly identified AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia with ins(5;11)(q31;q13q23).
TLDR
AF5q31 and AF4 might define a new family particularly involved in the pathogenesis of 11q23-associated-ALL, which is associated with extremely poor prognosis as compared with other 11Q23 translocations.
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