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ADAM17 protein, human

Known as: TNF-Alpha-Converting Enzyme, TNF-Alpha Convertase, Antigen CD156b 
Disintegrin and metalloproteinase domain-containing protein 17 (824aa, ~93 kDa) is encoded by the human ADAM17 gene. This protein is involved in… 
National Institutes of Health

Related topics

Related topics

15 relations

Broader (1)

ADAM17 Protein
ADAM17 geneADAM17 wt AlleleAlzheimer's Disease Pathway KEGGDisintegrin Domain

Papers overview

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Highly Cited
2012
Highly Cited
2012
iRhom2 Regulation of TACE Controls TNF-Mediated Protection Against Listeria and Responses to LPS
TACE Trafficking The cytokine tumor necrosis factor (TNF) is a major driver of inflammation and contributes to the immune… 
Highly Cited
2009
Highly Cited
2009
Pref-1 regulates mesenchymal cell commitment and differentiation through Sox9.
Highly Cited
2006
Highly Cited
2006
Rapid Modulation of P-Glycoprotein-Mediated Transport at the Blood-Brain Barrier by Tumor Necrosis Factor-α and Lipopolysaccharide
At the blood-brain barrier, P-glycoprotein, an ATP-driven drug efflux pump, selectively limits drug access to the brain… 
Highly Cited
2005
Highly Cited
2005
Timp3 deficiency in insulin receptor-haploinsufficient mice promotes diabetes and vascular inflammation via increased TNF-alpha.
Activation of inflammatory pathways may contribute to the beginning and the progression of both atherosclerosis and type 2… 
Highly Cited
2004
Highly Cited
2004
In Vitro Ischemic Tolerance Involves Upregulation of Glutamate Transport Partly Mediated by the TACE/ADAM17-Tumor Necrosis Factor-α Pathway
A short ischemic event [ischemic preconditioning (IPC)] can result in a subsequent resistance to severe ischemic injury (ischemic… 
Highly Cited
2003
Highly Cited
2003
Cellular Cholesterol Depletion Triggers Shedding of the Human Interleukin-6 Receptor by ADAM10 and ADAM17 (TACE)*
Interleukin-6 (IL-6) activates cells by binding to the membrane-bound IL-6 receptor (IL-6R) and subsequent formation of a… 
Highly Cited
2002
Highly Cited
2002
Transmembrane collagen XVII, an epithelial adhesion protein, is shed from the cell surface by ADAMs
Collagen XVII, a type II transmembrane protein and epithelial adhesion molecule, can be proteolytically shed from the cell… 
Highly Cited
2002
Highly Cited
2002
Shedding light on sheddases: role in growth and development.
The extracellular domains of several integral membrane proteins are released from the cell surface by a group of enzymes known as… 
Review
2001
Review
2001
TACE and other ADAM proteases as targets for drug discovery.
Highly Cited
1999
Highly Cited
1999
Metalloprotease-Disintegrin MDC9: Intracellular Maturation and Catalytic Activity*
Metalloprotease disintegrins are a family of membrane-anchored glycoproteins that are known to function in fertilization… 
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