Disintegrin Domain

It is an integrin binding domain originally identified in ADAM family proteins. (NCI)
National Institutes of Health

Related topics

Related topics

10 relations
ADAM-TS9 protein, humanADAM11 protein, humanADAM12 protein, humanADAM15 protein, human
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Papers overview

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2006
2006
ADAM22, expressed in normal brain but not in high-grade gliomas, inhibits cellular proliferation via the disintegrin domain.
OBJECTIVE To study the expression and function of the brain-specific proteinase deficient disintegrins, ADAM11 and ADAM22 (a… (More)
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2005
2005
ADAM disintegrin-like domain recognition by the lymphocyte integrins alpha4beta1 and alpha4beta7.
The ADAM (a disintegrin and metalloprotease) family of proteins possess both proteolytic and adhesive domains. We have… (More)
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2004
2004
Evidence of antiangiogenic and antimetastatic activities of the recombinant disintegrin domain of metargidin.
Metargidin, a transmembrane protein of the adamalysin family, and integrins, e.g., alpha5beta1 and alphav, are preferentially… (More)
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Highly Cited
2003
Highly Cited
2003
Cleavage of von Willebrand factor requires the spacer domain of the metalloprotease ADAMTS13.
ADAMTS13 consists of a reprolysin-type metalloprotease domain followed by a disintegrin domain, a thrombospondin type 1 motif… (More)
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Highly Cited
2002
Highly Cited
2002
The metalloprotease disintegrin ADAM8. Processing by autocatalysis is required for proteolytic activity and cell adhesion.
ADAMs (a disintegrin and metalloprotease domains) are metalloprotease and disintegrin domain-containing transmembrane… (More)
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Highly Cited
2001
Highly Cited
2001
Sequence-specific interaction between the disintegrin domain of mouse ADAM 3 and murine eggs: role of beta1 integrin-associated proteins CD9, CD81, and CD98.
ADAM 3 is a sperm surface glycoprotein that has been implicated in sperm-egg adhesion. Because little is known about the adhesive… (More)
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Highly Cited
1997
Highly Cited
1997
A Role for the Disintegrin Domain of Cyritestin, a Sperm Surface Protein Belonging to the ADAM Family, in Mouse Sperm–Egg Plasma Membrane Adhesion and Fusion
Sperm-egg plasma membrane fusion is preceded by sperm adhesion to the egg plasma membrane. Cell-cell adhesion frequently involves… (More)
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Highly Cited
1996
Highly Cited
1996
Metargidin, a membrane-anchored metalloprotease-disintegrin protein with an RGD integrin binding sequence.
Cellular disintegrins are a family of membrane-anchored proteins with structural homology to snake venom metalloproteases and… (More)
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Highly Cited
1996
Highly Cited
1996
MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains
Cellular disintegrins are a family of proteins that are related to snake venom integrin ligands and metalloproteases. We have… (More)
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Review
1992
Review
1992
Structure, function and evolutionary relationship of proteins containing a disintegrin domain
Disintegrins are soluble integrin ligands from snake venoms that disrupt cell-matrix interactions. Recently, the nuclear magnetic… (More)
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