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Disintegrin Domain

It is an integrin binding domain originally identified in ADAM family proteins. (NCI)
National Institutes of Health

Related topics

Related topics

10 relations
ADAM-TS9 protein, humanADAM11 protein, humanADAM12 protein, humanADAM15 protein, human
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Papers overview

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Highly Cited
2006
Highly Cited
2006
α9β1: A Novel Osteoclast Integrin That Regulates Osteoclast Formation and Function
We identified a previously unknown integrin, α9β1, on OCLs and their precursors. Antibody to α9 inhibited OCL formation in human… 
Highly Cited
2003
Highly Cited
2003
Cleavage of von Willebrand Factor Requires the Spacer Domain of the Metalloprotease ADAMTS13*
ADAMTS13 consists of a reprolysin-type metalloprotease domain followed by a disintegrin domain, a thrombospondin type 1 motif… 
Highly Cited
2002
Highly Cited
2002
The Metalloprotease Disintegrin ADAM8
ADAMs (a disintegrinand metalloprotease domains) are metalloprotease and disintegrin domain-containing transmembrane… 
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Highly Cited
2001
Highly Cited
2001
Sequence-specific interaction between the disintegrin domain of mouse ADAM 3 and murine eggs: role of beta1 integrin-associated proteins CD9, CD81, and CD98.
ADAM 3 is a sperm surface glycoprotein that has been implicated in sperm-egg adhesion. Because little is known about the adhesive… 
Highly Cited
2000
Highly Cited
2000
Sequence-specific Interaction between the Disintegrin Domain of Mouse ADAM 2 (Fertilin β) and Murine Eggs
Little is yet known about the biological and biochemical properties of the disintegrin-like domains of ADAM (a disintegrin… 
Highly Cited
1999
Highly Cited
1999
Disintegrin-like/cysteine-rich region of ADAM 12 is an active cell adhesion domain.
ADAM (a disintegrin and metalloprotease) proteins contain structural homology to the P-III class of snake venom metalloproteases… 
Highly Cited
1997
Highly Cited
1997
A Role for the Disintegrin Domain of Cyritestin, a Sperm Surface Protein Belonging to the ADAM Family, in Mouse Sperm–Egg Plasma Membrane Adhesion and Fusion
Sperm–egg plasma membrane fusion is preceded by sperm adhesion to the egg plasma membrane. Cell–cell adhesion frequently involves… 
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Highly Cited
1996
Highly Cited
1996
MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains
Cellular disintegrins are a family of proteins that are related to snake venom integrin ligands and metalloproteases. We have… 
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Highly Cited
1996
Highly Cited
1996
Metargidin, a Membrane-anchored Metalloprotease-Disintegrin Protein with an RGD Integrin Binding Sequence (*)
Cellular disintegrins are a family of membrane-anchored proteins with structural homology to snake venom metalloproteases and… 
Review
1992
Review
1992
Structure, function and evolutionary relationship of proteins containing a disintegrin domain
Disintegrins are soluble integrin ligands from snake venoms that disrupt cell-matrix interactions. Recently, the nuclear magnetic… 
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