Skip to search formSkip to main contentSkip to account menu

Disintegrin Domain

It is an integrin binding domain originally identified in ADAM family proteins. (NCI)
National Institutes of Health

Related topics

Related topics

10 relations
ADAM-TS9 protein, humanADAM11 protein, humanADAM12 protein, humanADAM15 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2006
2006
ADAM22, Expressed in Normal Brain but not in High-Grade Gliomas, Inhibits Cellular Proliferation via the Disintegrin Domain
OBJECTIVE:To study the expression and function of the brain-specific proteinase deficient disintegrins, ADAM11 and ADAM22 (a… 
Highly Cited
2005
Highly Cited
2005
The disintegrin domain of ADAM9: a ligand for multiple beta1 renal integrins.
Renal tubular epithelial cells in all nephron segments express a distinct member of the metalloprotease-disintegrin family, ADAM9… 
2005
2005
ADAM disintegrin-like domain recognition by the lymphocyte integrins alpha4beta1 and alpha4beta7.
The ADAM (a disintegrin and metalloprotease) family of proteins possess both proteolytic and adhesive domains. We have… 
Highly Cited
2004
Highly Cited
2004
Evidence of Antiangiogenic and Antimetastatic Activities of the Recombinant Disintegrin Domain of Metargidin
Metargidin, a transmembrane protein of the adamalysin family, and integrins, e.g., α5β1 and αv, are preferentially expressed on… 
2002
2002
Analysis of the roles of RGD-binding integrins, alpha(4)/alpha(9) integrins, alpha(6) integrins, and CD9 in the interaction of the fertilin beta (ADAM2) disintegrin domain with the mouse egg membrane…
Fertilin beta (also known as ADAM2), a mammalian sperm protein that mediates gamete cell adhesion during fertilization, is a… 
Highly Cited
2001
Highly Cited
2001
Sequence-specific interaction between the disintegrin domain of mouse ADAM 3 and murine eggs: role of beta1 integrin-associated proteins CD9, CD81, and CD98.
ADAM 3 is a sperm surface glycoprotein that has been implicated in sperm-egg adhesion. Because little is known about the adhesive… 
Highly Cited
1999
Highly Cited
1999
Interaction of metargidin (ADAM-15) with alphavbeta3 and alpha5beta1 integrins on different haemopoietic cells.
Metargidin (ADAM-15) is a type I transmembrane glycoprotein belonging to the ADAM (A Disintegrin and Metalloprotease Domain… 
1998
1998
Roles of the disintegrin domains of mouse fertilins alpha and beta in fertilization.
Fertilin is a heterodimer of alpha and beta subunits, both of which are members of the ADAM (A Disintegrin and A Metalloprotease… 
1997
1997
Evidence that peptides derived from the disintegrin domain of primate fertilin and containing the ECD motif block the binding of human spermatozoa to the zona-free hamster oocyte.
The binding of human spermatozoa to, and penetration of, zona-free hamster oocytes were significantly inhibited in the presence… 
Review
1992
Review
1992
Structure, function and evolutionary relationship of proteins containing a disintegrin domain
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)