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ADAM17 Protein

Known as: ADAM17 Protein [Chemical/Ingredient], TNF-alpha Convertase, ADAM-17 
A disintegrin and metalloproteinase domain-containing protein that cleaves the membrane-bound precursor of TUMOR NECROSIS FACTOR-ALPHA to its mature… 
National Institutes of Health

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ADAM17 geneADAM17 wt AlleleIn BloodProcess of secretion

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ADAM17 protein, human

Papers overview

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2010
2010
Development of predictive pharmacophore model for in silico screening, and 3D QSAR CoMFA and CoMSIA studies for lead optimization, for designing of potent tumor necrosis factor alpha converting…
A chemical feature-based pharmacophore model was developed for Tumor Necrosis Factor-α converting enzyme (TACE) inhibitors. A… 
Highly Cited
2008
Highly Cited
2008
TACE/ADAM-17: A Component of the Epidermal Growth Factor Receptor Axis and a Promising Therapeutic Target in Colorectal Cancer
Purpose: Activation of the epidermal growth factor receptor (EGFR) requires cell surface cleavage of EGFR ligands, uptake of… 
Highly Cited
2006
Highly Cited
2006
Ectodomain Shedding of Preadipocyte Factor 1 (Pref-1) by Tumor Necrosis Factor Alpha Converting Enzyme (TACE) and Inhibition of Adipocyte Differentiation
ABSTRACT Preadipocyte factor 1 (Pref-1), an epidermal growth factor repeat containing transmembrane protein found in the… 
Highly Cited
2006
Highly Cited
2006
The TNF alpha converting enzyme (TACE/ADAM17) is expressed in the atherosclerotic lesions of apolipoprotein E-deficient mice: possible contribution to elevated plasma levels of soluble TNF alpha…
2006
2006
FHL2 interacts with both ADAM‐17 and the cytoskeleton and regulates ADAM‐17 localization and activity
ADAM‐17 is a metalloprotease‐disintegrin responsible for the ectodomain shedding of several transmembrane proteins. Using the… 
Highly Cited
2003
Highly Cited
2003
Expression of ADAMs (a disintegrin and metalloproteases) and TIMP-3 (tissue inhibitor of metalloproteinase-3) in human prostatic adenocarcinomas.
A disintegrin and metalloproteases (ADAMs) are proteins that contain both a disintegrin and metalloprotease domain and have… 
Highly Cited
2003
Highly Cited
2003
Identification of SAP97 as an intracellular binding partner of TACE
Tumor necrosis factor alpha converting enzyme (TACE) is the metalloprotease-disintegrin responsible for the ectodomain shedding… 
2003
2003
Discovery of N-hydroxy-2-(2-oxo-3-pyrrolidinyl)acetamides as potent and selective inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).
Highly Cited
2001
Highly Cited
2001
Regulation of Membrane Metalloproteolytic Cleavage of L-selectin (CD62L) by the Epidermal Growth Factor Domain*
The adhesion molecule L-selectin is cleaved rapidly from the surface of activated leukocytes by tumor necrosis factor… 
1999
1999
cDNA cloning of mouse tumor necrosis factor-alpha converting enzyme (TACE) and partial analysis of its promoter.
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