Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

ADAM17 protein, human

Known as: TNF-Alpha-Converting Enzyme, TNF-Alpha Convertase, Antigen CD156b 
Disintegrin and metalloproteinase domain-containing protein 17 (824aa, ~93 kDa) is encoded by the human ADAM17 gene. This protein is involved in… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
BACKGROUND Alzheimer's disease (AD) is the most common neurodegenerative disorder, neuropathologically characterized by… Expand
  • table 1
Is this relevant?
Highly Cited
2011
Highly Cited
2011
Tumor necrosis factor-α–converting enzyme (TACE; also known as ADAM17) is a proteolytic sheddase that is responsible for the… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2010
Highly Cited
2010
CD163 is expressed specifically in the monocyte/macrophage lineage, where it mediates uptake of haptoglobin-hemoglobin complexes… Expand
Is this relevant?
Highly Cited
2007
Highly Cited
2007
TNF-alpha, a potent proinflammatory cytokine, is synthesized as a membrane-anchored precursor and proteolytically released from… Expand
  • figure 1
  • table I
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2007
Highly Cited
2007
The incidence of Alzheimer disease (AD) and vascular dementia is greatly increased following cerebral ischemia and stroke in… Expand
Is this relevant?
Highly Cited
2006
Highly Cited
2006
At the blood-brain barrier, P-glycoprotein, an ATP-driven drug efflux pump, selectively limits drug access to the brain… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2004
Highly Cited
2004
A short ischemic event [ischemic preconditioning (IPC)] can result in a subsequent resistance to severe ischemic injury (ischemic… Expand
Is this relevant?
Highly Cited
2003
Highly Cited
2003
Interleukin-6 (IL-6) activates cells by binding to the membrane-bound IL-6 receptor (IL-6R) and subsequent formation of a… Expand
  • figure 1
  • figure 3
  • figure 2
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Fractalkine (CX3CL1) is an unusual member of the chemokine family that is synthesized with its chemokine domain at the end of a… Expand
Is this relevant?
Highly Cited
1998
Highly Cited
1998
The amyloid protein, Abeta, which accumulates in the brains of Alzheimer patients, is derived by proteolysis of the amyloid… Expand
Is this relevant?