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ADAM17 gene
Known as:
A DISINTEGRIN AND METALLOPROTEINASE DOMAIN 17
, ADAM metallopeptidase domain 17
, TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME
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This gene plays a role in the cleavage of membrane proteins, resulting in the release of their extracellular domains from cells.
National Institutes of Health
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Related topics
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6 relations
ADAM12 gene
ADAM17 Protein
ADAM17 protein, human
Hydrolysis
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
The role of the metalloprotease ADAM17 in metastasis
J. Bolik
2019
Corpus ID: 199038532
Metastasis is the major cause of death in cancer patients. Especially, patients undergoing primary tumor resection are at a high…
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Review
2018
Review
2018
ADAM17 overexpression is associated with poorer clinical outcomes in cancer patients: a systematic review and meta-analysis
Xufeng Peng
,
Bo Hao
,
Nai-Long Cao
,
Ji‐hong Wang
,
Xiangguo Lv
,
Xinru Zhang
2018
Corpus ID: 80167617
// XuFeng Peng 1, * , Bo Hao 3, * , Nailong Cao 1 , Jihong Wang 1 , Xiangguo Lv 2 and XinRu Zhang 1 1 Department of Urology…
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2017
2017
The soluble protease ADAMDEC 1 released from activated platelets hydrolyzes platelet membrane pro-EGF to active high molecular weight EGF
R. Chen
,
G. Jin
,
T. McIntyre
2017
Corpus ID: 33161550
Platelets are the sole source of EGF in the circulation, yet how EGF is stored or released from stimulated cells are undefined…
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2017
2017
FIRST-IN-CLASS ANTAGONISTIC TACE ANTIBODY
2017
Corpus ID: 171084614
The anti-TACE antibody comes with an extensive package of data demonstrating high affinity binding, potent inhibitory action…
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2014
2014
ADAM 17 silencing suppresses the migration and invasion of non-small cell lung cancer
Xiaohong Lv
,
Li Yang
,
+4 authors
Dong-Hua Qian
2014
Corpus ID: 27844274
A disintegrin and metalloprotease (ADAM) 17 has been implicated in the tumor progression of various types of solid tumor; however…
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2013
2013
Molecular descriptors in modeling of TNF-α converting enzyme (TACE) inhibition activity of 2-(2-aminothiazol-4-yl)pyrrolidine-based tartrate diamides
P. Singh
2013
Corpus ID: 8904002
A quantitative structure-activity relationship (QSAR) study has been carried out on a new series of tartrate-based compounds to…
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2011
2011
Therapeutics , Targets , and Chemical Biology Oncogenic Kras Promotes Chemotherapy-Induced Growth Factor Shedding via ADAM 17
S. Van Schaeybroeck
,
J. Kyula
,
+5 authors
P. Johnston
2011
Corpus ID: 10093803
Oncogenic mutations in Kras occur in 40% to 45% of patients with advanced colorectal cancer (CRC). We have previously shown that…
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2010
2010
Cancer degradomics: ADAM17 regulates TGF-beta signaling through the cleavage of vasorin
F. Malapeira
,
Cary Esselens
,
J. Bech-Serra
,
N. Colomé
,
J. Arribas
,
F. Canals Suris
2010
Corpus ID: 53752649
2008
2008
Study of the effects of LPS on the TACE gene expression and its function
Ling-Bo Li
,
Yu-zhen Yang
,
Zhen Wang
,
F. Gong
Journal of Huazhong University of Science and…
2008
Corpus ID: 24125934
SummaryIn order to investigate the effects of LPS on the TACE gene transcription and expression and its regulating effect on the…
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2006
2006
Rapid Communication ADAM 17 Mediates Epidermal Growth Factor Receptor Transactivation and Vascular Smooth Muscle Cell Hypertrophy Induced by Angiotensin II
H. Ohtsu
,
P. Dempsey
,
+6 authors
S. Eguchi
2006
Corpus ID: 5904844
Background—Angiotensin II (Ang II) promotes growth of vascular smooth muscle cells (VSMCs) via epidermal growth factor (EGF…
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