ADAM17 gene

Known as: A DISINTEGRIN AND METALLOPROTEINASE DOMAIN 17, ADAM metallopeptidase domain 17, TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME 
This gene plays a role in the cleavage of membrane proteins, resulting in the release of their extracellular domains from cells.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
The Fc receptor CD16 is present on essentially all CD56(dim) peripheral blood natural killer (NK) cells. Upon recognition of… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2011
Highly Cited
2011
We performed genetic and immunohistochemical studies in a sister and brother with autosomal recessive neonatal inflammatory skin… (More)
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2010
Highly Cited
2010
The protease a disintegrin and metalloprotease (ADAM) 17 cleaves tumor necrosis factor (TNF), L-selectin, and epidermal growth… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2009
Highly Cited
2009
Notch signaling requires a series of proteolytic cleavage events to release the Notch intracellular domain (NICD) that functions… (More)
Is this relevant?
Highly Cited
2007
Highly Cited
2007
Cleavage and release (shedding) of membrane proteins is a critical regulatory step in many normal and pathological processes… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2007
Highly Cited
2007
TNF-alpha, a potent proinflammatory cytokine, is synthesized as a membrane-anchored precursor and proteolytically released from… (More)
Is this relevant?
Review
2005
Review
2005
The transmembrane metzinkin-proteases of the ADAM (a disintegrin and a metalloproteinase)-family ADAM10 and ADAM 17 are both… (More)
Is this relevant?
Highly Cited
2004
Highly Cited
2004
All ligands of the epidermal growth factor receptor (EGFR), which has important roles in development and disease, are released… (More)
  • table I
  • table II
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2003
Highly Cited
2003
The putative alpha-secretase cleaves the amyloid precursor protein (APP) of Alzheimer's disease in the middle of the amyloid beta… (More)
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Fractalkine (CX3CL1) is an unusual member of the chemokine family that is synthesized with its chemokine domain at the end of a… (More)
Is this relevant?