Pref-1 regulates mesenchymal cell commitment and differentiation through Sox9.

@article{Wang2009Pref1RM,
  title={Pref-1 regulates mesenchymal cell commitment and differentiation through Sox9.},
  author={Y X Rachel Wang and Hei Sook Sul},
  journal={Cell metabolism},
  year={2009},
  volume={9 3},
  pages={287-302}
}
Pref-1 is an EGF repeat-containing transmembrane protein that produces a biologically active soluble form by TACE-mediated cleavage. Although Pref-1 inhibition of adipogenesis has been well established, the specific target(s) of Pref-1 or the Pref-1 function in mesenchymal cell commitment/differentiation are not known. Here, we show that Sox9 downregulation… CONTINUE READING