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ABCG2 protein, human

Known as: methotrexate carrier protein, human, methotrexate transporter protein, human, CDw338 
ATP-binding cassette sub-family G member 2 (655 aa, ~72 kDa) is encoded by the human ABCG2 gene. This protein is involved in the transport of urate… 
National Institutes of Health

Related topics

Related topics

19 relations
ABCG2 geneABCG2 wt AlleleAdenosine TriphosphatasesCellular Membrane

Broader (2)

ATP Binding Cassette Transporter, Sub-Family G, Member 2Neoplasm Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Crystal structure of the multidrug exporter MexB from Pseudomonas aeruginosa.
Highly Cited
2009
Highly Cited
2009
Major SNP (Q141K) Variant of Human ABC Transporter ABCG2 Undergoes Lysosomal and Proteasomal Degradations
PurposeSingle nucleotide polymorphisms (SNPs) of the ATP-binding cassette (ABC) transporter ABCG2 gene have been suggested to be… 
Highly Cited
2007
Highly Cited
2007
P-Glycoprotein and Breast Cancer Resistance Protein: Two Dominant Transporters Working Together in Limiting the Brain Penetration of Topotecan
Purpose: The brain is a pharmacologic sanctuary site, due to the presence of the blood-brain barrier (BBB). Whereas the effect of… 
Highly Cited
2006
Highly Cited
2006
Role of BCRP 421C>A polymorphism on rosuvastatin pharmacokinetics in healthy Chinese males.
Highly Cited
2006
Highly Cited
2006
Expression of breast cancer resistance protein (BCRP/ABCG2) in human placenta throughout gestation and at term before and after labor.
Breast cancer resistance protein, BCRP, is a multidrug resistance protein that is highly expressed in the human placenta. In… 
Review
2004
Review
2004
ABCG2 – a transporter for all seasons
Highly Cited
2004
Highly Cited
2004
Breast Cancer Resistance Protein Impacts Clinical Outcome in Platinum-Based Chemotherapy for Advanced Non-Small Cell Lung Cancer
Purpose: The purpose of this study was to investigate the relationship between the level of expression of ATP-binding cassette… 
Highly Cited
2003
Highly Cited
2003
Side population cells and Bcrp1 expression in lung.
Side population (SP) cells are a rare subset of cells found in various tissues that are highly enriched for stem cell activity… 
Highly Cited
2002
Highly Cited
2002
Nestin-positive progenitor cells derived from adult human pancreatic islets of Langerhans contain side population (SP) cells defined by expression of the ABCG2 (BCRP1) ATP-binding cassette…
Highly Cited
2002
Highly Cited
2002
Multidrug resistance protein 2 (MRP2) transports HIV protease inhibitors, and transport can be enhanced by other drugs
Background: Various drug transporters of the ATP-binding cassette (ABC) family restrict the oral bioavailability and cellular… 
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