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ABCG2 gene

Known as: EST157481, ATP-Binding Cassette, Sub-Family G (WHITE), Member 2 (Junior Blood Group), MXR 
This gene plays a role in xenobiotic transport and multi-drug resistance.
National Institutes of Health

Related topics

Related topics

8 relations
ABCG2 protein, humanABCG2 wt AlleleDrug EffluxHomo sapiens

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Evaluation of Limiting Brain Penetration Related to P-glycoprotein and Breast Cancer Resistance Protein Using [11C]GF120918 by PET in Mice
PurposeGF120918 has a high inhibitory effect on P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP). We developed… 
2007
2007
Involvement of Breast Cancer Resistance Protein (BCRP/ABCG2) in the Biliary Excretion and Intestinal Efflux of Troglitazone Sulfate, the Major Metabolite of Troglitazone with a Cholestatic Effect
Troglitazone sulfate (TGZS) is the major metabolite of troglitazone (TGZ), an antidiabetic agent, and thought to be a cause of… 
2006
2006
BCRP/ABCG2 levels account for the resistance to topoisomerase I inhibitors and reversal effects by gefitinib in non-small cell lung cancer
Purpose: Breast cancer resistance protein (BCRP) confers resistance against topoisomerase I inhibitors in cancer cells. Very… 
Highly Cited
2005
Highly Cited
2005
EFFECTS OF DIHYDROPYRIDINES AND PYRIDINES ON MULTIDRUG RESISTANCE MEDIATED BY BREAST CANCER RESISTANCE PROTEIN: IN VITRO AND IN VIVO STUDIES
Breast cancer resistance protein (BCRP, ABCG2) is a recently identified member of the ATP-binding cassette family of cell surface… 
Highly Cited
2005
Highly Cited
2005
Effect of Walker A mutation (K86M) on oligomerization and surface targeting of the multidrug resistance transporter ABCG2
The ATP binding cassette (ABC) half-transporter ABCG2 (MXR/BCRP/ABCP) is associated with mitoxantrone resistance accompanied by… 
2005
2005
Characterization of Polarized Expression of Point- or Deletion-Mutated Human BCRP/ABCG2 in LLC-PK1 Cells
No HeadingPurpose.In polarized cells, such as hepatocytes and intestinal epithelial cells, transporters are localized on the… 
Review
2004
Review
2004
Reversing agents for ATP-binding cassette (ABC) transporters: application in modulating multidrug resistance (MDR).
  • Chow H Lee
  • Current Medicinal Chemistry - Anti-Cancer Agents
  • 2004
  • Corpus ID: 20311717
One of the main reasons for the failure in cancer chemotherapy is the existence of multidrug resistance (MDR) mechanisms. One… 
2004
2004
Cells resistant to HTI-286 do not overexpress P-glycoprotein but have reduced drug accumulation and a point mutation in alpha-tubulin.
HTI-286, a synthetic analogue of hemiasterlin, depolymerizes microtubules and is proposed to bind at the Vinca peptide site in… 
Highly Cited
2001
Highly Cited
2001
Inhibition of BCRP-mediated drug efflux by fumitremorgin-type indolyl diketopiperazines.
Highly Cited
2001
Highly Cited
2001
P-glycoprotein in the catfish intestine: inducibility by xenobiotics and functional properties.
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