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ABCG2 protein, human

Known as: methotrexate carrier protein, human, methotrexate transporter protein, human, CDw338 
ATP-binding cassette sub-family G member 2 (655 aa, ~72 kDa) is encoded by the human ABCG2 gene. This protein is involved in the transport of urate… 
National Institutes of Health

Related topics

Related topics

19 relations
ABCG2 geneABCG2 wt AlleleAdenosine TriphosphatasesCellular Membrane

Broader (2)

ATP Binding Cassette Transporter, Sub-Family G, Member 2Neoplasm Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2010
Review
2010
Structure and function of the human breast cancer resistance protein (BCRP/ABCG2).
The human breast cancer resistance protein (BCRP/ABCG2) is the second member of the G subfamily of the large ATP-binding cassette… 
Highly Cited
2009
Highly Cited
2009
MicroRNA-328 Negatively Regulates the Expression of Breast Cancer Resistance Protein (BCRP/ABCG2) in Human Cancer Cells
Breast cancer resistance protein (BCRP/ABCG2) is a molecular determinant of pharmacokinetic properties of many drugs in humans… 
Highly Cited
2008
Highly Cited
2008
The breast cancer resistance protein transporter ABCG2 is expressed in the human kidney proximal tubule apical membrane.
The Breast Cancer Resistance Protein (BCRP/ABCG2) is a transporter restricting absorption and enhancing excretion of many… 
Highly Cited
2005
Highly Cited
2005
ABCG2 Transporter Identifies a Population of Clonogenic Human Limbal Epithelial Cells
ABCG2, a member of the ATP binding cassette (ABC) transporters, has been identified as a molecular determinant for bone marrow… 
Highly Cited
2004
Highly Cited
2004
Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump.
Imatinib mesylate (STI571), a potent tyrosine kinase inhibitor, is successfully used in the treatment of chronic myelogenous… 
Review
2003
Review
2003
Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2)
Observations of functional adenosine triphosphate (ATP)-dependent drug efflux in certain multidrug-resistant cancer cell lines… 
Highly Cited
2002
Highly Cited
2002
Frequent expression of the multi‐drug resistance‐associated protein BCRP/MXR/ABCP/ABCG2 in human tumours detected by the BXP‐21 monoclonal antibody in paraffin‐embedded material
Breast cancer resistance protein (BCRP/MXR/ABCP/ABCG2; hereafter ABCG2) is a member of the ATP‐binding‐cassette family of… 
Highly Cited
2002
Highly Cited
2002
Localisation of breast cancer resistance protein in microvessel endothelium of human brain
Movement of substrates between blood and brain is known to be influenced by P-glycoprotein (P-gp) at the luminal surface of the… 
Highly Cited
2001
Highly Cited
2001
Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells.
ABCG2 (also called MXR (3), BCRP (4), or ABCP (5) is a recently-identified ABC half-transporter, which causes multidrug… 
Highly Cited
1998
Highly Cited
1998
A multidrug resistance transporter from human MCF-7 breast cancer cells.
MCF-7/AdrVp is a multidrug-resistant human breast cancer subline that displays an ATP-dependent reduction in the intracellular… 
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