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8-hydroxyclomipramine

Known as: 5H-Dibenz(b,f)azepin-1-ol, 7-chloro-5-(3-(dimethylamino)propyl)-10,11-dihydro- 
National Institutes of Health

Related topics

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2 relations

Broader (1)

Clomipramine
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2005
2005
Steady-state plasma levels of clomipramine and its metabolites: Impact of the sparteine/debrisoquine oxidation polymorphism
SummaryAfter an initial placebo week, 37 depressed in-patients were treated with the fixed dose of 75 mg clomipramine b. d. A… Expand
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2005
2005
Non-competitive inhibition of clomipramineN-demethylation by fluvoxamine
The selective serotonin reuptake inhibitor fluvoxamine interferes with the metabolism of tricyclic antidepressants. The present… Expand
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2004
2004
Glucuronidation clearance of 8-hydroxyclomipramine in relation to sparteine and mephenytoin phenotype
Bertilsson et al. [1] reported a depressed patient who was an extremely rapid hydroxylator of both debrisoquine and nortriptyline… Expand
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2001
2001
The Effect of CYP2C19 and CYP2D6 Genotypes on the Metabolism of Clomipramine in Japanese Psychiatric Patients
In this study, the authors investigated the relationship between the metabolism of clomipramine (C) and the genotypes of… Expand
1997
1997
Monitoring serum concentrations of clomipramine and metabolites: fluorescence polarization immunoassay versus high performance liquid chromatography.
This study compared fluorescence polarization immunoassay (FPIA) with a high performance liquid chromatographic (HPLC) method… Expand
Highly Cited
1996
Highly Cited
1996
The biotransformation of clomipramine in vitro, identification of the cytochrome P450s responsible for the separate metabolic pathways.
The aim of the study was to identify the cytochrome P450s (CYPs) that catalyze the biotransformation of clomipramine in vitro. A… Expand
1995
1995
Metabolism of Clomipramine in a Japanese Psychiatric Population: Hydroxylation, Desmethylation, and Glucuronidation
We measured the concentrations of clomipramine and its metabolites, N-desmethylclomipramine, 8-hydroxy-N-desmethylclomipramine, 8… Expand
1993
1993
Clinical significance of plasma levels of clomipramine, its hydroxylated and desmethylated metabolites: prediction of clinical outcome in mood disorders using discriminant analysis of therapeutic…
We measured the plasma concentrations of clomipramine and its metabolites, N-desmethylclompiramine, 8-hydroxy-N… Expand
1993
1993
Interindividual variations of desmethylation and hydroxylation of clomipramine in an Oriental psychiatric population.
We measured the concentrations of clomipramine and its metabolites, N-desmethylclomipramine, 8-hydroxy-N-desmethylclomipramine… Expand
1982
1982
Plasma steady‐state concentrations of hydroxylated metabolites of clomipramine
Plasma clomipramine, desmethylclomipramine, 8‐hydroxyclomipramine, and 8‐hydroxydesmethylclomipramine concentrations were… Expand
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