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SummaryAfter an initial placebo week, 37 depressed in-patients were treated with the fixed dose of 75 mg clomipramine b. d. A… Expand The selective serotonin reuptake inhibitor fluvoxamine interferes with the metabolism of tricyclic antidepressants. The present… Expand Bertilsson et al.  reported a depressed patient who was an extremely rapid hydroxylator of both debrisoquine and nortriptyline… Expand In this study, the authors investigated the relationship between the metabolism of clomipramine (C) and the genotypes of… Expand This study compared fluorescence polarization immunoassay (FPIA) with a high performance liquid chromatographic (HPLC) method… Expand The aim of the study was to identify the cytochrome P450s (CYPs) that catalyze the biotransformation of clomipramine in vitro. A… Expand We measured the concentrations of clomipramine and its metabolites, N-desmethylclomipramine, 8-hydroxy-N-desmethylclomipramine, 8… Expand We measured the plasma concentrations of clomipramine and its metabolites, N-desmethylclompiramine, 8-hydroxy-N… Expand We measured the concentrations of clomipramine and its metabolites, N-desmethylclomipramine, 8-hydroxy-N-desmethylclomipramine… Expand Plasma clomipramine, desmethylclomipramine, 8‐hydroxyclomipramine, and 8‐hydroxydesmethylclomipramine concentrations were… Expand