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8-hydroxyclomipramine
Known as:
5H-Dibenz(b,f)azepin-1-ol, 7-chloro-5-(3-(dimethylamino)propyl)-10,11-dihydro-
National Institutes of Health
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Broader (1)
Clomipramine
analogs & derivatives
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2005
2005
Steady-state plasma levels of clomipramine and its metabolites: Impact of the sparteine/debrisoquine oxidation polymorphism
K. Kramer Nielsen
,
K. Brøsen
,
L. Gram
,
Danish University Antidepressant Group
European Journal of Clinical Pharmacology
2005
Corpus ID: 23690781
SummaryAfter an initial placebo week, 37 depressed in-patients were treated with the fixed dose of 75 mg clomipramine b. d. A…
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2005
2005
Non-competitive inhibition of clomipramineN-demethylation by fluvoxamine
S. Härtter
,
C. Hiemke
,
M. Arand
,
F. Oesch
Psychopharmacology
2005
Corpus ID: 21422827
The selective serotonin reuptake inhibitor fluvoxamine interferes with the metabolism of tricyclic antidepressants. The present…
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2001
2001
The Effect of CYP2C19 and CYP2D6 Genotypes on the Metabolism of Clomipramine in Japanese Psychiatric Patients
A. Yokono
,
S. Morita
,
T. Someya
,
G. Hirokane
,
M. Okawa
,
K. Shimoda
Journal of Clinical Psychopharmacology
2001
Corpus ID: 46151342
In this study, the authors investigated the relationship between the metabolism of clomipramine (C) and the genotypes of…
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1997
1997
Monitoring serum concentrations of clomipramine and metabolites: fluorescence polarization immunoassay versus high performance liquid chromatography.
M. Banger
,
B. Hermes
,
S. Härtter
,
C. Hiemke
Pharmacopsychiatry
1997
Corpus ID: 23945618
This study compared fluorescence polarization immunoassay (FPIA) with a high performance liquid chromatographic (HPLC) method…
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Highly Cited
1996
Highly Cited
1996
The biotransformation of clomipramine in vitro, identification of the cytochrome P450s responsible for the separate metabolic pathways.
K. Nielsen
,
J. Flinois
,
P. Beaune
,
K. Brøsen
Journal of Pharmacology and Experimental…
1996
Corpus ID: 19255963
The aim of the study was to identify the cytochrome P450s (CYPs) that catalyze the biotransformation of clomipramine in vitro. A…
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1995
1995
Metabolism of Clomipramine in a Japanese Psychiatric Population: Hydroxylation, Desmethylation, and Glucuronidation
K. Shimoda
,
T. Noguchi
,
+4 authors
Saburo Takahashi
Neuropsychopharmacology
1995
Corpus ID: 32811110
1994
1994
Glucuronidation clearance of 8-hydroxyclomipramine in relation to sparteine and mephenytoin phenotype
K. Nielsen
,
K. Brøsen
,
L. Gram
,
M. G. Hansen
European Journal of Clinical Pharmacology
1994
Corpus ID: 33677290
Bertilsson et al. [1] reported a depressed patient who was an extremely rapid hydroxylator of both debrisoquine and nortriptyline…
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1993
1993
Clinical significance of plasma levels of clomipramine, its hydroxylated and desmethylated metabolites: prediction of clinical outcome in mood disorders using discriminant analysis of therapeutic…
T. Noguchi
,
K. Shimoda
,
S. Takahashi
Journal of Affective Disorders
1993
Corpus ID: 3791633
1993
1993
Interindividual variations of desmethylation and hydroxylation of clomipramine in an Oriental psychiatric population.
K. Shimoda
,
T. Minowada
,
T. Noguchi
,
S. Takahashi
Journal of Clinical Psychopharmacology
1993
Corpus ID: 37532710
We measured the concentrations of clomipramine and its metabolites, N-desmethylclomipramine, 8-hydroxy-N-desmethylclomipramine…
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1982
1982
Plasma steady‐state concentrations of hydroxylated metabolites of clomipramine
M. Linnoila
,
T. Insel
,
C. Kilts
,
W. Potter
,
D. Murphy
Clinical pharmacology and therapy
1982
Corpus ID: 25009288
Plasma clomipramine, desmethylclomipramine, 8‐hydroxyclomipramine, and 8‐hydroxydesmethylclomipramine concentrations were…
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