Clomipramine

Known as: 5H-Dibenz(b,f)azepine-5-propanamine, 3-chloro-10,11-dihydro-N,N-dimethyl-, Clomipramina, 3-Chloroimipramine 
A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the… (More)
National Institutes of Health

Related topics

Related topics

30 relations

Narrower (6)

8-hydroxyclomipramineAnafranilClomicalmHydiphen
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Affective Disorders, PsychoticClomipramine HydrochlorideClomipramine:MCnc:Pt:Ser/Plas:QnClomipramine:SCnc:Pt:Ser/Plas:Qn
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Broader (5)

AminesAntidepressive AgentsCarbamazepineSerotonin Uptake Inhibitors
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
N-Desalkylquetiapine, a Potent Norepinephrine Reuptake Inhibitor and Partial 5-HT1A Agonist, as a Putative Mediator of Quetiapine's Antidepressant Activity
Quetiapine is an atypical antipsychotic drug that is also US FDA approved for treating bipolar depression, albeit by an unknown… (More)
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Highly Cited
2007
Highly Cited
2007
Intralipid outperforms sodium bicarbonate in a rabbit model of clomipramine toxicity.
STUDY OBJECTIVE Previous investigators have demonstrated amelioration of lipid-soluble drug toxidromes with infusion of lipid… (More)
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Highly Cited
2005
Highly Cited
2005
Randomized, placebo-controlled trial of exposure and ritual prevention, clomipramine, and their combination in the treatment of obsessive-compulsive disorder.
OBJECTIVE The purpose of the study was to test the relative and combined efficacy of clomipramine and exposure and ritual… (More)
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Highly Cited
2004
Highly Cited
2004
The potent in vitro antioxidant ellagitannins from pomegranate juice are metabolised into bioavailable but poor antioxidant hydroxy-6H-dibenzopyran-6-one derivatives by the colonic microflora of…
BACKGROUND The antiatherogenic activity of pomegranate juice has been attributed to its antioxidant polyphenols. The most potent… (More)
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Highly Cited
2003
Highly Cited
2003
Evaluation of the bioavailability and metabolism in the rat of punicalagin, an antioxidant polyphenol from pomegranate juice.
BACKGROUND & AIMS Punicalagin is an antioxidant ellagitannin of pomegranate juice. This compound is responsible for the high… (More)
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Highly Cited
1998
Highly Cited
1998
Comparison of aerobic exercise, clomipramine, and placebo in the treatment of panic disorder.
OBJECTIVE The purpose of this study was to compare the therapeutic effect of exercise for patients with panic disorder to a drug… (More)
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Highly Cited
1998
Highly Cited
1998
Cannabinoids activate mesolimbic dopamine neurons by an action on cannabinoid CB1 receptors.
The present study was designed to determine if cannabinoids share with other drugs of abuse the ability to stimulate mesolimbic… (More)
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Highly Cited
1991
Highly Cited
1991
Differential effects of clomipramine given locally or systemically on extracellular 5-hydroxytryptamine in raphe nuclei and frontal cortex
The antidepressant drug clomipramine (CIM) blocks 5-hydroxytryptamine (5-HT) uptake in vitro. Electrophysiological studies have… (More)
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Highly Cited
1990
Highly Cited
1990
Paroxetine: a selective serotonin reuptake inhibitor showing better tolerance, but weaker antidepressant effect than clomipramine in a controlled multicenter study. Danish University Antidepressant…
  • Journal of affective disorders
  • 1990
Antidepressant effects and unintended effects of paroxetine (30 mg/day) and clomipramine (150 mg/day) were compared in a double… (More)
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Highly Cited
1989
Highly Cited
1989
A double-blind comparison of clomipramine and desipramine in the treatment of trichotillomania (hair pulling)
Trichotillomania, an irresistible impulse to pull out one's own hair, is a chronic psychiatric illness that causes severe… (More)
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