5,10-methylenetetrahydrofolate

Known as: 5,10 methylenetetrahydrofolate, MTHF, FOLITIXORIN 
A folate-based biomodulator with potential antineoplastic activity. 5,10-methylenetetrahydrofolate (MTHF) stabilizes the covalent binding of the… (More)
National Institutes of Health

Papers overview

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Highly Cited
2002
Highly Cited
2002
DNA methylation, an essential epigenetic feature of DNA that modulates gene expression and genomic integrity, is catalyzed by… (More)
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Review
2000
Review
2000
Methylenetetrahydrofolate reductase (MTHFR) plays a central role in the folate cycle and contributes to the metabolism of the… (More)
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Highly Cited
1999
Highly Cited
1999
Reduction of 5,10-methylenetetrahydrofolate (methyleneTHF), a donor for methylating dUMP to dTMP in DNA synthesis, to 5… (More)
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Highly Cited
1997
Highly Cited
1997
Folate derivatives are important in experimental colorectal carcinogenesis; low folate intake, particularly with substantial… (More)
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Highly Cited
1997
Highly Cited
1997
BACKGROUND Epidemiological studies have identified hyperhomocyst(e)inemia as an independent risk factor for coronary artery… (More)
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Highly Cited
1996
Highly Cited
1996
We examined the relationship of a common polymorphism (667C-->T) of the methylenetetrahydrofolate reductase (MTHFR) gene with the… (More)
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Highly Cited
1995
Highly Cited
1995
Hyperhomocysteinaemia has been identified as a risk factor for cerebrovascular, peripheral vascular and coronary heart disease1–4… (More)
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Highly Cited
1995
Highly Cited
1995
Thermolability of 5,10-methylenetetrahydrofolate reductase (MTHFR) was examined as a possible cause of mild hyperhomocysteinemia… (More)
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Highly Cited
1995
Highly Cited
1995
Periconceptional folate supplementation reduces the risk of neural-tube defects. We studied the frequency of the 677C-->T… (More)
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Highly Cited
1995
Highly Cited
1995
It is now well-established that folic acid, taken peri-conceptionally, can reduce the risk of neural tube defects (NTDs). Recent… (More)
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