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5,10-methylenetetrahydrofolate

Known as: 5,10 methylenetetrahydrofolate, MTHF, FOLITIXORIN 
A folate-based biomodulator with potential antineoplastic activity. 5,10-methylenetetrahydrofolate (MTHF) stabilizes the covalent binding of the… 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (2)

5,10-methylenetetrahydrofolic acidFolacin

Narrower (1)

CoFactor brand of 5,10-methylenetetrahydrofolate
NCIt Antineoplastic Agent Terminology

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2000
2000
Comorbidity of 5,10-methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms and risk for neural tube defects
Editor—Neural tube defects (NTDs) are among the most common and devastating birth defects. NTDs result from an incomplete closure… 
1998
1998
D221 in thymidylate synthase controls conformation change, and thereby opening of the imidazolidine.
In thymidylate synthase (TS), the invariant residue Asp-221 provides the only side chain that hydrogen bonds to the pterin ring… 
1998
1998
677→CT mutation on the methylenetetrahydrofolate reductase gene is not a risk factor for neural tube defects in Turkey
Editor—Recent studies have shown that periconceptual folic acid supplementation reduces a woman’s risk of having a baby with… 
1997
1997
Genetic Polymorphism of 5,10-Methylenetetrahydrofolate Reductase (MTHFR) as a Risk Factor for Coronary Artery Disease
Background Epidemiological studies have identified hyperhomocyst(e)inemia as an independent risk factor for coronary artery… 
Highly Cited
1983
Highly Cited
1983
Primary structure of the Escherichia coli thyA gene and its thymidylate synthase product.
The nucleotide sequence of a 1,163-base-pair fragment that encodes the entire thyA gene of Escherichia coli K-12 was determined… 
1980
1980
Hydrodynamic behavior of human and bacterial thymidylate synthetases and thymidylate synthetase--5-fluoro-2'-deoxyuridylate--5,10-methylenetetrahydrofolate complexes. Evidence for large…
The conformations of thymidylate synthetases from CCRF-CEM human leukemic cells and Lactobacillus casei were studied by… 
1979
1979
Thymidylate synthetase from Escherichia coli K12. Purification, and dependence of kinetic properties on sugar conformation and size of the 2' substituent.
Thymidylate synthetase from Escherichia coli K12 has been purified 3600-fold by a series of chromatographic procedures. The final… 
Highly Cited
1979
Highly Cited
1979
Assay of intracellular free and macromolecular-bound metabolites of 5-fluorodeoxyuridine and 5-fluorouracil.
Methods have been developed to assay several aspects of 5-fluoro-2'-deoxyuridine and 5-fluorouracil metabolism in tissue culture… 
Highly Cited
1979
Highly Cited
1979
Purification of mammalian tumor (L1210) thymidylate synthetase by affinity chromatography on stable biospecific adsorbent. Stabilization of the enzyme with neutral detergents.
Thymidylate synthetase from mouse leukemic L1210 cells was purified to electrophoretic homogeneity with 70% yield as a result of… 
1977
1977
Stereochemistry of methylene transfer involving 5,10-methylenetetrahydrofolate.
The stereochemistry of the transfer catalyzed by rabbit liver serine transhydroxymethylase (EC 2.1.2.1) of the prochiral… 
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