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5,10-methylenetetrahydrofolate
Known as:
5,10 methylenetetrahydrofolate
, MTHF
, FOLITIXORIN
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A folate-based biomodulator with potential antineoplastic activity. 5,10-methylenetetrahydrofolate (MTHF) stabilizes the covalent binding of the…
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National Institutes of Health
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Related topics
Related topics
4 relations
Broader (2)
5,10-methylenetetrahydrofolic acid
Folacin
Narrower (1)
CoFactor brand of 5,10-methylenetetrahydrofolate
NCIt Antineoplastic Agent Terminology
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and susceptibility to ischemic stroke: a meta-analysis.
Pingping Li
,
C. Qin
Gene
2014
Corpus ID: 23145744
Highly Cited
2005
Highly Cited
2005
Polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and susceptibility to pediatric acute lymphoblastic leukemia in a German study population
E. Schnakenberg
,
Andrea Mehles
,
+7 authors
M. Stanulla
BMC Medical Genetics
2005
Corpus ID: 5233515
BackgroundMethylenetetrahydrofolate reductase (MTHFR) has a major impact on the regulation of the folic acid pathway due to…
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1998
1998
Methenyltetrahydrofolate cyclohydrolase is rate limiting for the enzymatic conversion of 10-formyltetrahydrofolate to 5,10-methylenetetrahydrofolate in bifunctional dehydrogenase-cyclohydrolase…
P. Pawelek
,
R. Mackenzie
Biochemistry
1998
Corpus ID: 33631526
The kinetic properties of three methylenetetrahydrofolate dehydrogenase-cyclohydrolase (D/C) enzymes (the NADP-dependent…
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Highly Cited
1991
Highly Cited
1991
Determination of rates and yields of interchromophore (folate----flavin) energy transfer and intermolecular (flavin----DNA) electron transfer in Escherichia coli photolyase by time-resolved…
S. T. Kim
,
P. F. Heelis
,
T. Okamura
,
Y. Hirata
,
N. Mataga
,
A. Sancar
Biochemistry
1991
Corpus ID: 9545406
Escherichia coli DNA photolyase, which photorepairs cyclobutane pyrimidine dimers, contains two chromophore cofactors, 1,5…
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Highly Cited
1988
Highly Cited
1988
Primary structure of a human trifunctional enzyme. Isolation of a cDNA encoding methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase.
D. Hum
,
Alexander W. Bell
,
Rima Rozen
,
R E MacKenzie
Journal of Biological Chemistry
1988
Corpus ID: 32188410
Highly Cited
1988
Highly Cited
1988
Isolation and characterization of the Saccharomyces cerevisiae MIS1 gene encoding mitochondrial C1-tetrahydrofolate synthase.
K. Shannon
,
J. Rabinowitz
Journal of Biological Chemistry
1988
Corpus ID: 37578040
Highly Cited
1986
Highly Cited
1986
The A+T-rich genome of Herpesvirus saimiri contains a highly conserved gene for thymidylate synthase.
R. Honess
,
W. Bodemer
,
K. Cameron
,
H. Niller
,
B. Fleckenstein
,
R. Randall
Proceedings of the National Academy of Sciences…
1986
Corpus ID: 25290036
Herpesvirus saimiri (HVS) is the prototype member of a distinctive subset of lymphotropic herpesviruses (the gamma 2 subgroup…
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Highly Cited
1983
Highly Cited
1983
Primary structure of the Escherichia coli thyA gene and its thymidylate synthase product.
M. Belfort
,
G. Maley
,
J. Pedersen-Lane
,
F. Maley
Proceedings of the National Academy of Sciences…
1983
Corpus ID: 28843469
The nucleotide sequence of a 1,163-base-pair fragment that encodes the entire thyA gene of Escherichia coli K-12 was determined…
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Highly Cited
1982
Highly Cited
1982
The effect of derivatives of folic acid on the fluorodeoxyuridylate-thymidylate synthetase covalent complex in human colon xenografts.
J. Houghton
,
C. Schmidt
,
P. Houghton
European Journal of Cancer and Clinical Oncology
1982
Corpus ID: 26541877
Highly Cited
1979
Highly Cited
1979
Biochemical determinants of tumor sensitivity to 5-fluorouracil: ultrasensitive methods for the determination of 5-fluoro-2'-deoxyuridylate, 2'-deoxyuridylate, and thymidylate synthetase.
R. Moran
,
C. P. Spears
,
C. Heidelberger
Proceedings of the National Academy of Sciences…
1979
Corpus ID: 7452132
Techniques have been developed to measure FdUMP, the active metabolite of 5-FUra; thymidylate synthetase (TMP synthase; 5,10…
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