5,10-methylenetetrahydrofolate

Known as: 5,10 methylenetetrahydrofolate, MTHF, FOLITIXORIN 
A folate-based biomodulator with potential antineoplastic activity. 5,10-methylenetetrahydrofolate (MTHF) stabilizes the covalent binding of the… (More)
National Institutes of Health

Related topics

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3 relations

Broader (2)

5,10-methylenetetrahydrofolic acidFolacin

Narrower (1)

CoFactor brand of 5,10-methylenetetrahydrofolate

Papers overview

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Highly Cited
2002
Highly Cited
2002
A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status.
DNA methylation, an essential epigenetic feature of DNA that modulates gene expression and genomic integrity, is catalyzed by… (More)
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Review
2000
Review
2000
Molecular biology of 5,10-methylenetetrahydrofolate reductase.
Methylenetetrahydrofolate reductase (MTHFR) plays a central role in the folate cycle and contributes to the metabolism of the… (More)
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Highly Cited
1999
Highly Cited
1999
Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults.
Reduction of 5,10-methylenetetrahydrofolate (methyleneTHF), a donor for methylating dUMP to dTMP in DNA synthesis, to 5… (More)
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Highly Cited
1997
Highly Cited
1997
Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer.
Folate derivatives are important in experimental colorectal carcinogenesis; low folate intake, particularly with substantial… (More)
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Highly Cited
1997
Highly Cited
1997
Genetic polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) as a risk factor for coronary artery disease.
BACKGROUND Epidemiological studies have identified hyperhomocyst(e)inemia as an independent risk factor for coronary artery… (More)
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Highly Cited
1996
Highly Cited
1996
A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer.
We examined the relationship of a common polymorphism (667C-->T) of the methylenetetrahydrofolate reductase (MTHFR) gene with the… (More)
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Highly Cited
1995
Highly Cited
1995
A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase
Hyperhomocysteinaemia has been identified as a risk factor for cerebrovascular, peripheral vascular and coronary heart disease1–4… (More)
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Highly Cited
1995
Highly Cited
1995
Thermolabile 5,10-methylenetetrahydrofolate reductase as a cause of mild hyperhomocysteinemia.
Thermolability of 5,10-methylenetetrahydrofolate reductase (MTHFR) was examined as a possible cause of mild hyperhomocysteinemia… (More)
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Highly Cited
1995
Highly Cited
1995
Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida
Periconceptional folate supplementation reduces the risk of neural-tube defects. We studied the frequency of the 677C-->T… (More)
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Highly Cited
1995
Highly Cited
1995
A genetic defect in 5,10 methylenetetrahydrofolate reductase in neural tube defects.
It is now well-established that folic acid, taken peri-conceptionally, can reduce the risk of neural tube defects (NTDs). Recent… (More)
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