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5,10-methylenetetrahydrofolate

Known as: 5,10 methylenetetrahydrofolate, MTHF, FOLITIXORIN 
A folate-based biomodulator with potential antineoplastic activity. 5,10-methylenetetrahydrofolate (MTHF) stabilizes the covalent binding of the… 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (2)

5,10-methylenetetrahydrofolic acidFolacin

Narrower (1)

CoFactor brand of 5,10-methylenetetrahydrofolate
NCIt Antineoplastic Agent Terminology

Papers overview

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Highly Cited
2014
Highly Cited
2014
Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and susceptibility to ischemic stroke: a meta-analysis.
Highly Cited
2005
Highly Cited
2005
Polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and susceptibility to pediatric acute lymphoblastic leukemia in a German study population
BackgroundMethylenetetrahydrofolate reductase (MTHFR) has a major impact on the regulation of the folic acid pathway due to… 
1998
1998
Methenyltetrahydrofolate cyclohydrolase is rate limiting for the enzymatic conversion of 10-formyltetrahydrofolate to 5,10-methylenetetrahydrofolate in bifunctional dehydrogenase-cyclohydrolase…
The kinetic properties of three methylenetetrahydrofolate dehydrogenase-cyclohydrolase (D/C) enzymes (the NADP-dependent… 
Highly Cited
1991
Highly Cited
1991
Determination of rates and yields of interchromophore (folate----flavin) energy transfer and intermolecular (flavin----DNA) electron transfer in Escherichia coli photolyase by time-resolved…
Escherichia coli DNA photolyase, which photorepairs cyclobutane pyrimidine dimers, contains two chromophore cofactors, 1,5… 
Highly Cited
1988
Highly Cited
1988
Primary structure of a human trifunctional enzyme. Isolation of a cDNA encoding methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase.
Highly Cited
1988
Highly Cited
1988
Isolation and characterization of the Saccharomyces cerevisiae MIS1 gene encoding mitochondrial C1-tetrahydrofolate synthase.
Highly Cited
1986
Highly Cited
1986
The A+T-rich genome of Herpesvirus saimiri contains a highly conserved gene for thymidylate synthase.
Herpesvirus saimiri (HVS) is the prototype member of a distinctive subset of lymphotropic herpesviruses (the gamma 2 subgroup… 
Highly Cited
1983
Highly Cited
1983
Primary structure of the Escherichia coli thyA gene and its thymidylate synthase product.
The nucleotide sequence of a 1,163-base-pair fragment that encodes the entire thyA gene of Escherichia coli K-12 was determined… 
Highly Cited
1982
Highly Cited
1982
The effect of derivatives of folic acid on the fluorodeoxyuridylate-thymidylate synthetase covalent complex in human colon xenografts.
Highly Cited
1979
Highly Cited
1979
Biochemical determinants of tumor sensitivity to 5-fluorouracil: ultrasensitive methods for the determination of 5-fluoro-2'-deoxyuridylate, 2'-deoxyuridylate, and thymidylate synthetase.
Techniques have been developed to measure FdUMP, the active metabolite of 5-FUra; thymidylate synthetase (TMP synthase; 5,10… 
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