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The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence.
TLDR
This review represents an update of the nomenclature system for the UDP glucuronosyltransferase gene superfamily, which is based on divergent evolution and is anticipated that this UGT gene nomenClature system will require updating on a regular basis. Expand
Relative enzymatic activity, protein stability, and tissue distribution of human steroid-metabolizing UGT2B subfamily members.
TLDR
The relative activities and the major substrates of human steroid-metabolizing UGT2B enzymes, which are expressed in a wide variety of steroid target tissues, are clearly demonstrated. Expand
Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element.
TLDR
Bile acids that are activators of the nuclear receptor farnesoid X receptor (FXR) as negative regulators of human apoA-I expression are identified and promoter mutation analysis and gel-shift experiments in HepG2 cells demonstrated that bile acid-activated FXR decreases human apos A-I promoter activity by a negative FXR response element mapped to the C site. Expand
3'-azido-3'-deoxythimidine (AZT) is glucuronidated by human UDP-glucuronosyltransferase 2B7 (UGT2B7).
TLDR
The glucuronidation of AZT by UGT2B7, which is a UGT 2B protein expressed in the liver, is consistent with previous findings and supports the physiological relevance of this enzyme in AZT conjugation. Expand
Hepatoprotective effects of the dual peroxisome proliferator‐activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
TLDR
The dual PPAR‐α/δ agonist, GFT505, is a promising liver‐targeted drug for treatment of NAFLD/NASH and in animals, its protective effects are mediated by both PPar‐α‐dependent and ‐independent mechanisms. Expand
Regulation of the Human P450scc Gene by Steroidogenic Factor 1 Is Mediated by CBP/p300*
TLDR
Results indicate that regulation of the human P450scc gene by SF-1 is mediated by p300/CBP, and coexpression of fragments of the p300 protein fused to the VP16 protein in the presence of SF-2 indicated in vivo the interaction of two regions of p300 withSF-1, thus confirming the in vitro results. Expand
Isolation and Characterization of a Novel cDNA Encoding a Human UDP-Glucuronosyltransferase Active on C19 Steroids*
TLDR
UGT2B17 is the first human uridine diphosphoglucuronosyltransferase enzyme expressed in extrahepatic tissues to have a specificity for ADT as well as testosterone, dihydrotestosterone, and 3α-diol. Expand
Isolation and characterization of UGT2B15(Y85): a UDP-glucuronosyltransferase encoded by a polymorphic gene.
TLDR
Specific reverse transcriptase (RT)-PCR analysis revealed expression of the UGT2B15 gene in a wide range of extrahepatic tissues including the human liver, kidney, testis, mammary gland, placenta, adipose, skin, uterus, prostate and lung, indicating that it is a major glucuronidation enzyme in humans. Expand
Safety issues and prospects for future generations of PPAR modulators.
TLDR
This review mainly focuses on the preclinical and clinical adverse events of PPAR agonists that could be of concern when considering the development of new PPar agonists. Expand
Elafibranor, an Agonist of the Peroxisome Proliferator-Activated Receptor-α and -δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening.
TLDR
A post-hoc analysis of data from trial of patients with NASH showed that elafibranor (120 mg/d for 1 year) resolved NASH without fibrosis worsening, based on a modified definition, in the intention-to-treat analysis and in patients with moderate or severe NASH. Expand
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