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5' Flanking Region

Known as: Flanking Sequences, 5', Sequence, 5' Flanking, Regions, 5' Flanking 
The region of DNA which borders the 5' end of a transcription unit and where a variety of regulatory sequences are located.
National Institutes of Health

Related topics

Related topics

3 relations
5' Untranslated Regionsaspects of radiation effectsphysiological aspects

Papers overview

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Review
2006
Review
2006
A family affair: var genes, PfEMP1 binding, and malaria disease.
Highly Cited
1998
Highly Cited
1998
Fluid shear stress activation of egr-1 transcription in cultured human endothelial and epithelial cells is mediated via the extracellular signal-related kinase 1/2 mitogen-activated protein kinase…
The primary response transcription factor, early growth response-1 (Egr-1), is rapidly activated by a variety of extracellular… 
Highly Cited
1992
Highly Cited
1992
Silencing the type II sodium channel gene: A model for neural-specific gene regulation
Highly Cited
1989
Highly Cited
1989
Gene replacement in Dictyostelium: generation of myosin null mutants.
The eukaryotic slime mold Dictyostelium discoideum has a single conventional myosin heavy chain gene (mhcA). The elimination of… 
Highly Cited
1989
Highly Cited
1989
The 5′ flanking region of the pS2 gene contains a complex enhancer region responsive to oestrogens, epidermal growth factor, a tumour promoter (TPA), the c‐Ha‐ras oncoprotein and the c‐jun protein.
Expression of the pS2 gene which is transcriptionally controlled by oestrogens in the breast cancer cell line MCF‐7 is oestrogen… 
Highly Cited
1987
Highly Cited
1987
Iron regulates ferritin mRNA translation through a segment of its 5' untranslated region.
In previous studies, we showed that acute administration of iron to intact rats or to rat hepatoma cells in culture induces… 
Highly Cited
1985
Highly Cited
1985
Lens-specific expression and developmental regulation of the bacterial chloramphenicol acetyltransferase gene driven by the murine alpha A-crystallin promoter in transgenic mice.
Two lines of transgenic mice with one to two copies of a DNA fragment containing nucleotides -364 to +45 of the murine alpha A… 
Highly Cited
1984
Highly Cited
1984
A 12-base-pair DNA motif that is repeated several times in metallothionein gene promoters confers metal regulation to a heterologous gene.
To define DNA sequences involved in mouse metallothionein-I (MT-I) gene promoter function and metal regulation, we fused the 5… 
Highly Cited
1982
Highly Cited
1982
Clusters of genes encoding mouse transplantation antigens
Highly Cited
1980
Highly Cited
1980
Sequence of three copies of the gene for the major Drosophila heat shock induced protein and their flanking regions
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