G. Mandel

Publications163
h-index62
Citations19,547
Highly Influential Citations1,022
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REST and Its Corepressors Mediate Plasticity of Neuronal Gene Chromatin throughout Neurogenesis
TLDR
It is shown that REST regulates the transitions from pluripotent to neural stem/progenitor cell and from progenitor to mature neuron, indicating that REST defines a gene set subject to plasticity in mature neurons. Expand
REST: A mammalian silencer protein that restricts sodium channel gene expression to neurons
TLDR
It is proposed that expression of the type II sodium channel gene in neurons reflects a default pathway that is blocked in nonneuronal cells by the presence of REST. Expand
Reciprocal actions of REST and a microRNA promote neuronal identity
TLDR
It is shown that REST regulates the expression of a family of miRNAs, including brain-specific miR-124a, and the combined transcriptional and posttranscriptional consequences of REST action maximize the contrast between neuronal and nonneuronal cell phenotypes. Expand
CoREST: a functional corepressor required for regulation of neural-specific gene expression.
TLDR
It is shown that CoREST, a newly identified human protein, functions as a corepressor for REST, a structural feature of the nuclear receptor and silencing mediator for retinoid and thyroid human receptors (SMRT)-extended corepressors that mediate inducible repression by steroid hormone receptors. Expand
Defining the CREB Regulon A Genome-Wide Analysis of Transcription Factor Regulatory Regions
TLDR
This study represents the most comprehensive definition of transcription factor binding sites in a metazoan species. Expand
Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA
TLDR
It is found that MeCP2 translation is regulated by microRNA 132 (miR132) and this feedback loop may provide a mechanism for homeostatic control of Me CP2 expression. Expand
Compact Myelin Dictates the Differential Targeting of Two Sodium Channel Isoforms in the Same Axon
TLDR
The data show that sodium channel isoforms are differentially targeted to distinct domains of the same axon in a process associated with formation of compact myelin. Expand
Identification of a cyclic-AMP-responsive element within the rat somatostatin gene.
TLDR
The studies indicate that transcriptional regulation of the somatostatin gene by cAMP requires protein kinase 2 activity and may depend upon a highly conserved promoter element. Expand
Distribution of prospective glutamatergic, glycinergic, and GABAergic neurons in embryonic and larval zebrafish
TLDR
The intermingling of neurons expressing inhibitory and excitatory markers in spinal cord contrasted markedly with the organization in hindbrain, where neurons expressing a particular marker were clustered together to form stripes that were visible running from rostral to caudal in horizontal sections and from dorsomedial to ventrolateral in cross sections. Expand
Corepressor-Dependent Silencing of Chromosomal Regions Encoding Neuronal Genes
TLDR
The zinc-finger gene-specific repressor element RE-1 silencing transcription factor/neuronal restricted silencing factor (REST/NRSF) can mediate extraneuronal restriction by imposing either active repression via histone deacetylase recruitment or long-term gene silencing using a distinct functional complex. Expand
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