REST and Its Corepressors Mediate Plasticity of Neuronal Gene Chromatin throughout Neurogenesis
- N. Ballas, C. Grunseich, Diane D. A. Lu, J. Speh, G. Mandel
- BiologyCell
- 20 May 2005
REST: A mammalian silencer protein that restricts sodium channel gene expression to neurons
- J. Chong, J. Tapia-Ramírez, G. Mandel
- BiologyCell
- 24 March 1995
Reciprocal actions of REST and a microRNA promote neuronal identity
- C. Conaco, Stefanie J. Otto, Jong-Jin Han, G. Mandel
- BiologyProceedings of the National Academy of Sciences…
- 6 February 2006
It is shown that REST regulates the expression of a family of miRNAs, including brain-specific miR-124a, and the combined transcriptional and posttranscriptional consequences of REST action maximize the contrast between neuronal and nonneuronal cell phenotypes.
CoREST: a functional corepressor required for regulation of neural-specific gene expression.
- M. Andrés, C. Burger, G. Mandel
- BiologyProceedings of the National Academy of Sciences…
- 17 August 1999
It is shown that CoREST, a newly identified human protein, functions as a corepressor for REST, a structural feature of the nuclear receptor and silencing mediator for retinoid and thyroid human receptors (SMRT)-extended corepressors that mediate inducible repression by steroid hormone receptors.
Identification of a cyclic-AMP-responsive element within the rat somatostatin gene.
- M. Montminy, K. Sevarino, J. Wagner, G. Mandel, R. Goodman
- BiologyProceedings of the National Academy of Sciences…
- 1 September 1986
The studies indicate that transcriptional regulation of the somatostatin gene by cAMP requires protein kinase 2 activity and may depend upon a highly conserved promoter element.
Defining the CREB Regulon A Genome-Wide Analysis of Transcription Factor Regulatory Regions
- S. Impey, S. McCorkle, R. Goodman
- BiologyCell
- 29 December 2004
Compact Myelin Dictates the Differential Targeting of Two Sodium Channel Isoforms in the Same Axon
- Tatiana Boiko, M. Rasband, G. Matthews
- BiologyNeuron
- 1 April 2001
Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA
- Matthew E. Klein, Dan T. Lioy, Lin Ma, S. Impey, G. Mandel, R. Goodman
- BiologyNature Neuroscience
- 1 December 2007
It is found that MeCP2 translation is regulated by microRNA 132 (miR132) and this feedback loop may provide a mechanism for homeostatic control of Me CP2 expression.
Corepressor-Dependent Silencing of Chromosomal Regions Encoding Neuronal Genes
- V. Lunyak, R. Burgess, M. Rosenfeld
- BiologyScience
- 24 October 2002
The zinc-finger gene-specific repressor element RE-1 silencing transcription factor/neuronal restricted silencing factor (REST/NRSF) can mediate extraneuronal restriction by imposing either active repression via histone deacetylase recruitment or long-term gene silencing using a distinct functional complex.
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