• Publications
  • Influence
Requirement for Pax6 in corneal morphogenesis: a role in adhesion
The results indicate that cellular adhesion is compromised in the SEY (+/–) corneal epithelium and suggests a role for Pax6 in the proper generation and maintenance of the adult cornea. Expand
Role of Pax genes in eye evolution: a cnidarian PaxB gene uniting Pax2 and Pax6 functions.
The data suggest that the ancestor of jellyfish PaxB, a PaxB-like protein, was the primordial Pax protein in eye evolution and that Pax6-like genes evolved in triploblasts after separation from Cnidaria, raising the possibility that cnidarian and sophisticatedTriploblastic eyes arose independently. Expand
The cellular basis of corneal transparency: evidence for 'corneal crystallins'.
The results suggest that corneal cells, like lens cells, may preferentially express water-soluble proteins, often enzymes, for controlling their optical properties. Expand
Retinoic acid X receptor in the diploblast, Tripedalia cystophora.
It is shown by cDNA and gene cloning that a Cnidarian, Tripedalia cystophora, possesses a retinoid receptor (jRXR) with remarkable homology to vertebrate retinoic acid X receptors (RXRs), suggesting that RXR is an early component of the regulatory mechanisms of metazoa. Expand
Lens crystallins: the evolution and expression of proteins for a highly specialized tissue.
Crystallin Gene Promoters 497 Methylation 498 Transgenic Animals 498 Tissue, Developmental, and Spatial Specificity . Expand
Three-dimensional structure, catalytic properties, and evolution of a sigma class glutathione transferase from squid, a progenitor of the lens S-crystallins of cephalopods.
Comparisons of the primary structure, gene structure, and three-dimensional structure with class alpha, mu, and pi enzymes support placing the squid protein in a separate enzyme class, sigma, and suggests that the class sigma enzyme diverged from the ancestral precursor prior to the divergence of the precursor gene for the alpha,mu, andpi classes. Expand
Mafs, Prox1, and Pax6 Can Regulate Chicken βB1-Crystallin Gene Expression*
It is proposed that Pax6 occupies and represses the chicken βB1-crystallin promoter in lens epithelial cells, and is displaced by Prox1 and Mafs, which activate the promoter, in differentiating cortical fiber cells. Expand
Lens differentiation in vertebrates. A review of cellular and molecular features.
  • J. Piatigorsky
  • Biology, Medicine
  • Differentiation; research in biological diversity
  • 1 September 1981
Squid Pax-6 and eye development.
It is demonstrated that alternatively spliced RNAs derived from a single Pax-6 gene in the squid are expressed in the embryonic eye, olfactory organ, brain, and arms, and the results support the idea that Pax- 6 related genes are necessary for eye and Olfactory system formation throughout the animal kingdom. Expand
Conditional Deletion of the Mouse Klf4 Gene Results in Corneal Epithelial Fragility, Stromal Edema, and Loss of Conjunctival Goblet Cells
Excessive cell sloughing resulted in fewer epithelial cell layers in spite of increased cell proliferation at the Klf4CN ocular surface, and Expression of the keratin-12 and aquaporin-5 genes was downregulated, consistent with the K Alf4CN corneal epithelial fragility and stromal edema, respectively. Expand