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The cellular basis of corneal transparency: evidence for 'corneal crystallins'.
The results suggest that corneal cells, like lens cells, may preferentially express water-soluble proteins, often enzymes, for controlling their optical properties.
Requirement for Pax6 in corneal morphogenesis: a role in adhesion
- Janine Davis, M. Duncan, W. G. Robison, J. Piatigorsky
- Medicine, BiologyJournal of Cell Science
- 1 June 2003
The results indicate that cellular adhesion is compromised in the SEY (+/–) corneal epithelium and suggests a role for Pax6 in the proper generation and maintenance of the adult cornea.
Lens differentiation in vertebrates. A review of cellular and molecular features.
- J. Piatigorsky
- BiologyDifferentiation; research in biological diversity
- 1 September 1981
Role of Pax genes in eye evolution: a cnidarian PaxB gene uniting Pax2 and Pax6 functions.
Lens crystallins: the evolution and expression of proteins for a highly specialized tissue.
Crystallin Gene Promoters 497 Methylation 498 Transgenic Animals 498 Tissue, Developmental, and Spatial Specificity .
Retinoic acid X receptor in the diploblast, Tripedalia cystophora.
- Z. Kostrouch, M. Kostrouchová, W. Love, E. Jannini, J. Piatigorsky, J. E. Rall
- BiologyProceedings of the National Academy of Sciences…
- 10 November 1998
It is shown by cDNA and gene cloning that a Cnidarian, Tripedalia cystophora, possesses a retinoid receptor (jRXR) with remarkable homology to vertebrate retinoic acid X receptors (RXRs), suggesting that RXR is an early component of the regulatory mechanisms of metazoa.
Conditional Deletion of the Mouse Klf4 Gene Results in Corneal Epithelial Fragility, Stromal Edema, and Loss of Conjunctival Goblet Cells
- S. Swamynathan, J. Katz, K. Kaestner, R. Ashery-Padan, M. Crawford, J. Piatigorsky
- BiologyMolecular and Cellular Biology
- 23 October 2006
Excessive cell sloughing resulted in fewer epithelial cell layers in spite of increased cell proliferation at the Klf4CN ocular surface, and Expression of the keratin-12 and aquaporin-5 genes was downregulated, consistent with the K Alf4CN corneal epithelial fragility and stromal edema, respectively.
Three-dimensional structure, catalytic properties, and evolution of a sigma class glutathione transferase from squid, a progenitor of the lens S-crystallins of cephalopods.
Comparisons of the primary structure, gene structure, and three-dimensional structure with class alpha, mu, and pi enzymes support placing the squid protein in a separate enzyme class, sigma, and suggests that the class sigma enzyme diverged from the ancestral precursor prior to the divergence of the precursor gene for the alpha,mu, andpi classes.
Modulation of myocilin/TIGR expression in human trabecular meshwork.
- E. Tamm, P. Russell, D. Epstein, D. Johnson, J. Piatigorsky
- Biology, MedicineInvestigative ophthalmology & visual science
- 1 October 1999
Dynamic mechanical stimuli maintain myocilin/TIGR expression in TM in situ and lack of these stimuli in monolayer cell cultures might be involved in downregulation of myocILin/ tigR expression.
Mafs, Prox1, and Pax6 Can Regulate Chicken βB1-Crystallin Gene Expression*
- Wenwu Cui, S. Tomarev, J. Piatigorsky, A. B. Chepelinsky, M. Duncan
- BiologyJournal of Biological Chemistry
- 19 March 2004
It is proposed that Pax6 occupies and represses the chicken βB1-crystallin promoter in lens epithelial cells, and is displaced by Prox1 and Mafs, which activate the promoter, in differentiating cortical fiber cells.