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Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
Targeted gene disruption in the mouse shows that the Sonic hedgehog(Shh) gene plays a critical role in patterning of vertebrate embryonic tissues, including the brain and spinal cord, the axial
Regulation of cell fate decision of undifferentiated spermatogonia by GDNF.
TLDR
Transgenic loss-of-function and overexpression models show that the dosage of glial cell line-derived neurotrophic factor (GDNF), produced by Sertoli cells, regulates cell fate decisions of undifferentiated sperMatogonial cells that include the stem cells for spermatogenesis.
Efficient in vivo manipulation of mouse genomic sequences at the zygote stage.
TLDR
A transgenic mouse line carrying the cre transgene under the control of the adenovirus EIIa promoter that targets expression of the Cre recombinase to the early mouse embryo is described and loxP-flanked DNA sequences are efficiently deleted.
The LIM‐only protein Lmo2 is a bridging molecule assembling an erythroid, DNA‐binding complex which includes the TAL1, E47, GATA‐1 and Ldb1/NLI proteins
TLDR
It is shown that in erythroid cells Lmo2 forms a novel DNA‐binding complex, with GATA‐1, TAL1 and E2A, and the recently identified LIM‐binding protein Ldb1/NLI, which may play a role in haematopoiesis.
Defects in enteric innervation and kidney development in mice lacking GDNF
TLDR
It is demonstrated that GDNF induces ureter bud formation and branching during metanephros development, and is essential for proper innervation of the gastrointestinal tract.
The House Mouse: Atlas of Embryonic Development
TLDR
Molecular biologists tracing the effects of genetic manipulations, as well as students and researchers of developmental biology, will appreciate the renewed availability of this standard reference work for its unparalleled accuracy, its attention to anatomical detail, and the extent of its documentation.
Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators
TLDR
It is demonstrated that mPPAR alpha is the major isoform required for mediating the pleiotropic response resulting from the actions of peroxisome proliferators.
Sonic hedgehog is essential to foregut development
TLDR
Results indicate that Shh is required for the growth and differentiation of the oesophagus, trachea and lung, and suggest that mutations in SHH and its signalling components may be involved in foregut defects in humans.
Mouse models of Tay–Sachs and Sandhoff diseases differ in neurologic phenotype and ganglioside metabolism
TLDR
The Tay–Sachs and Sandhoff diseases are clinically similar neurodegenerative disorders and through disruption of the Hexa and Hexb genes in embryonic stem cells, mouse models corresponding to each disease are established.
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