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Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
Targeted gene disruption in the mouse shows that the Sonic hedgehog(Shh) gene plays a critical role in patterning of vertebrate embryonic tissues, including the brain and spinal cord, the axial… Expand
Regulation of cell fate decision of undifferentiated spermatogonia by GDNF.
The molecular control of self-renewal and differentiation of stem cells has remained enigmatic. Transgenic loss-of-function and overexpression models now show that the dosage of glial cell… Expand
The LIM‐only protein Lmo2 is a bridging molecule assembling an erythroid, DNA‐binding complex which includes the TAL1, E47, GATA‐1 and Ldb1/NLI proteins
The LIM‐only protein Lmo2, activated by chromosomal translocations in T‐cell leukaemias, is normally expressed in haematopoiesis. It interacts with TAL1 and GATA‐1 proteins, but the function of the… Expand
Efficient in vivo manipulation of mouse genomic sequences at the zygote stage.
- M. Lakso, J. Pichel, +5 authors H. Westphal
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 11 June 1996
We describe a transgenic mouse line carrying the cre transgene under the control of the adenovirus EIIa promoter that targets expression of the Cre recombinase to the early mouse embryo. To assess… Expand
Defects in enteric innervation and kidney development in mice lacking GDNF
GLIAL-CELL-LINE-DERIVED neurotrophic factor (GDNF) has been isolated as a neurotrophic factor for midbrain dopaminergic neurons1. Because of its neurotrophic activity on a wide range of neuronal… Expand
Sonic hedgehog is essential to foregut development
Congenital malformation of the foregut is common in humans, with an estimated incidence of 1 in 3000 live births, although its aetiology remains largely unknown. Mice with a targeted deletion of… Expand
Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators.
To gain insight into the function of peroxisome proliferator-activated receptor (PPAR) isoforms in rodents, we disrupted the ligand-binding domain of the alpha isoform of mouse PPAR (mPPAR alpha) by… Expand
Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse.
- M. Mukhopadhyay, S. Shtrom, +10 authors H. Westphal
- Biology, Medicine
- Developmental cell
- 1 September 2001
Dickkopf1 (Dkk1) is a secreted protein that acts as a Wnt inhibitor and, together with BMP inhibitors, is able to induce the formation of ectopic heads in Xenopus. Here, we show that Dkk1 null mutant… Expand
LIM Homeodomain Factors Lhx3 and Lhx4 Assign Subtype Identities for Motor Neurons
The circuits that control movement are comprised of discrete subtypes of motor neurons. How motor neuron subclasses develop and extend axons to their correct targets is still poorly understood. We… Expand
Mouse models of Tay–Sachs and Sandhoff diseases differ in neurologic phenotype and ganglioside metabolism
Tay–Sachs and Sandhoff diseases are clinically similar neurodegenerative disorders. These two sphingolipidoses are characterized by a heritable absence of β–hexosaminidase A resulting in defective… Expand