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11-methoxy-N-n-propylnoraporphine
Known as:
11-MeO-NPa
National Institutes of Health
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Aporphines
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Semantic Scholar uses AI to extract papers important to this topic.
2005
2005
Synthesis of 2-fluoro-11-hydroxy-N-propylnoraporphine: a potential dopamine D2 agonist.
A. Zhang
,
C. Csutoras
,
R. Zong
,
J. Neumeyer
Organic Letters
2005
Corpus ID: 33969245
[structure: see text]. 2-Fluoro-11-hydroxy-N-propylnoraporphine 4 (2-F-11-OH-NPa) was synthesized from thebaine in 13 steps with…
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2004
2004
Comparative assessment of dopamine agonist aporphines as anticonvulsants in two models of reflex epilepsy
G. Anlezark
,
D. Blackwood
,
B. Meldrum
,
V. Ram
,
J. Neumeyer
Psychopharmacology
2004
Corpus ID: 26738442
The anticonvulsant action of various aporphine derivatives that act on dopamine receptors has been investigated in two…
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1996
1996
10-substituted 11-oxygenated (R)-aporphines: synthesis, pharmacology, and modeling of 5-HT1A receptor interactions.
Martin H. Hedberg
,
Johanna M. Jansen
,
G. Nordvall
,
Stephan Hjorth
,
L. Unelius
,
A. Johansson
Journal of Medicinal Chemistry
1996
Corpus ID: 30030242
Derivatives of the selective serotonin 5-HT1A receptor agonist (R)-11-hydroxy-10-methylaporphine (2) having various substituents…
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1986
1986
Aporphines 65: chemical, microbial synthesis and characterization by gas chromatography/mass spectrometry of (R)-(-)-10-hydroxy 11-methoxy-N-n-propylnoraporphine, a potential metabolite of N-n…
J. Neumeyer
,
H. M. Abdel-Maksoud
,
T. Trainor
,
P. Vouros
,
P. Davis
Biomedical & environmental mass spectrometry
1986
Corpus ID: 25320595
The title compound has been synthesized by a multistep sequence from (R)(-)-morphine, and compared with the product obtained by…
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1983
1983
Motor inhibition induced by aporphine derivatives in the mouse
Amanda J. Bradbury
,
B. Costall
,
R. Naylor
,
J. Neumeyer
The Journal of pharmacy and pharmacology
1983
Corpus ID: 1866154
The ability of some aporphine and benzylisoquinoline derivatives to inhibit mouse spontaneous locomotor activity at low doses…
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1982
1982
Tissue levels of N-n-propylnorapomorphine after treatment with (−)10,11-methylenedioxy-N-n-propylnoraporphine, an orally long-acting prodrug active at central dopamine receptors
G. Sperk
,
A. Campbell
,
R. Baldessarini
,
A. Stoll
,
J. Neumeyer
Neuropharmacology
1982
Corpus ID: 35029242
1981
1981
Aporphines. 34. (-)-2,10,11-Trihydroxy-N-n-propylnoraporphine, a novel dopaminergic aporphine alkaloid with anticonvulsant activity.
J. Neumeyer
,
S. Law
,
B. Meldrum
,
G. Anlezark
,
K. Watling
Journal of Medicinal Chemistry
1981
Corpus ID: 19824748
(-)-2,10,11-Trihydroxy-N-n-propylnoraporphine (TNPA,2c) has been synthesized from thebaine (3a), via northebaine (3b…
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1977
1977
Aporphines, 21. (1,2) Dopaminergic activity of aporphine and benzylisoquinoline derivatives. Synthesis of 8-hydroxyaporphines and 1-(hydroxybenzyl)-2-n-propyl-1,2,3,4-tetrahydroisoquinolines.
B. Costall
,
R. Naylor
Journal of Medicinal Chemistry
1977
Corpus ID: 20765856
The synthesis and physical properties of 8-hydroxyaporphine (3a) and 8-hydroxy-N-n-propylnoraporphine (3b) are described. The…
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1976
1976
Aporphines. 14 Dopaminergic and antinociceptive activity of aporphine derivatives. Synthesis of 10-hydroxyaporphines and 10-hydroxy-N-n-propylnoraporphine.
J. Neumeyer
,
J. F. Reinhard
,
+4 authors
L. Agnati
Journal of Medicinal Chemistry
1976
Corpus ID: 7264756
The synthesis of racemic 10-hydroxyaporphine [(+/-)-2a] and 10-hydroxy-N-n-propylnoraporphine [(+/)-2b] is described. The method…
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