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SPECT imaging of dopamine and serotonin transporters with [123I]β‐CIT: Pharmacological characterization of brain uptake in nonhuman primates
It is suggested that [123I]β‐CIT will be a useful SPECT tracer of DA and 5‐HT transporters in living human brain.
Comparative nigrostriatal dopaminergic imaging with iodine-123-beta CIT-FP/SPECT and fluorine-18-FDOPA/PET.
Results indicate that [123I] beta CIT-FP/SPECT can provide quantitative descriptors of presynaptic dopaminergic function comparable to those obtained with [18F]FDOPA/PET.
Graphical, Kinetic, and Equilibrium Analyses of in vivo [123I]β-CIT Binding to Dopamine Transporters in Healthy Human Subjects
- M. Laruelle, E. Wallace, R. Innis
- BiologyJournal of cerebral blood flow and metabolism…
- 1 November 1994
Simulations indicated that the error associated with the day 2 equilibrium analysis was acceptable for plasma tracer terminal half-lives >10 h, and the equilibrium analysis on day 2 is proposed as the method of choice for clinical studies since it does not require multiple scans or the measurement of the arterial Plasma tracer concentrations.
Receptor affinities of dopamine D1 receptor-selective novel phenylbenzazepines.
The Sigma-RBI handbook of receptor classification and signal transduction
SPECT imaging of dopamine transporters in human brain with iodine-123-fluoroalkyl analogs of beta-CIT.
- A. Abi-Dargham, M. Gandelman, R. Innis
- Biology, ChemistryJournal of nuclear medicine : official…
- 1 July 1996
Preliminary results suggest that both compounds could be used as SPECT (labeled with 123I) or PET radiotracers to image the dopamine transporters in the living human brain.
Synthesis and dopamine receptor affinities of enantiomers of 2-substituted apomorphines and their N-n-propyl analogues.
- Y. Gao, R. Baldessarini, N. Kula, J. Neumeyer
- Chemistry, BiologyJournal of medicinal chemistry
- 1 June 1990
The structure-affinity relationships of these 2- substituted aporphines suggest that secondary binding sites of D2 receptors interact with 2-substituents on the A ring of aporPHines through H-bonding.
Cocaine receptors labeled by [3H]2 beta-carbomethoxy-3 beta-(4-fluorophenyl)tropane.
- B. Madras, R. Spealman, M. Fahey, J. Neumeyer, J. Saha, R. Milius
- Biology, ChemistryMolecular pharmacology
- 1 October 1989
The results show that [ 3H]CFT and [3H]cocaine bind to a similar spectrum of sites in monkey caudate putamen, with a high positive correlation (r, 0.99, p less than 0.001) between the affinities of drugs at sites labeled by [3h]C FT and [4-fluorophenyl)-tropane.
Dopamine transporter imaging with fluorine-18-FPCIT and PET.
FPCIT/PET demonstrated age-related decline in dopamine transporter binding in normal subjects as well as significant reductions in patients with idiopathic Parkinson's disease, which correlates with the disease severity.