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Subunit composition, distribution and function of GABA(A) receptor subtypes.
Together, these results should cause a revival of GABA(A) receptor research and strongly stimulate the development of drugs with a higher selectivity for alpha2-, alpha3-, or alpha5-subunit-containing receptor subtypes. Expand
Kainic acid seizures in the rat
  • G. Sperk
  • Medicine, Chemistry
  • Progress in Neurobiology
  • 31 January 1994
Neuropeptide Y: emerging evidence for a functional role in seizure modulation
Recent studies that have shown the changes induced by seizures in the level and distribution of NPY, its receptor subtypes and their respective mRNAs in rat forebrain suggest that NPY-mediated neurotransmission is altered by seizures. Expand
Powerful anticonvulsant action of IL-1 receptor antagonist on intracerebral injection and astrocytic overexpression in mice.
IL-1beta and its endogenous receptor antagonist (IL-1Ra) are rapidly induced by seizures in the rodent hippocampus. Exogenously applied IL-1beta prolongs seizures in an IL-1R type I-mediated manner.Expand
Kainic acid induced seizures: Neurochemical and histopathological changes
The most pronounced behavioural changes were strong immobility, increased incidence of "wet dog shakes", and long-lasting generalized tonic-clonic convulsions, suggesting a strongly increased firing rate of aminergic neurones during the period of generalized seizures. Expand
Multiple and Plastic Receptors Mediate Tonic GABAA Receptor Currents in the Hippocampus
It is shown that α5GABAARs contribute to tonic currents in pyramidal cells only when ambient GABA concentrations increase (as may occur during increased brain activity), and multiple components of tonic GABAA receptor-mediated conductance that are activated by low GABA concentrations are revealed. Expand
GABAA receptor subunits in the rat hippocampus II: Altered distribution in kainic acid-induced temporal lobe epilepsy
The data indicate an impairment of GABA-mediated neurotransmission due to a lasting loss of GABA(A) receptor containing cells after kainic acid-induced seizures. Expand
Anticonvulsant and Antiepileptogenic Effects Mediated by Adeno-Associated Virus Vector Neuropeptide Y Expression in the Rat Hippocampus
Targeted NPY gene transfer provides a potential therapeutic principle for the treatment of drug-resistant partial epilepsies in rats injected with the chimeric serotype 1/2 vector. Expand
Neuropeptide Y in the dentate gyrus.
Elevated expression of NPY in mossy fibers of the rat, sprouting ofNPY interneurons in the human dentate, and over-expression of Y2 receptors in mossY fibers indicate an anticonvulsive role of endogenousNPY in epilepsy, but the physiological role of NPy in the healthy dentate gyrus remains unclear. Expand
Kainic acid-induced seizures: Dose-relationship of behavioural neurochemical and histopathological changes
It is suggested that the irreversible brain lesions in this animal model of limbic (temporal lobe) epilepsy are not solely induced by a direct action of kainic acid, but may be caused--at least in part--by additional, secondary pathogenetic mechanisms. Expand