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International consensus study of antipsychotic dosing.
In the absence of adequate prospective, randomized drug-drug comparisons, the present findings provide broad, international, expert consensus-based recommendations for most clinically employed antipsychotic drugs that can support clinical practice, trial design, and interpretation of comparative antipsychotics trials. Expand
Tissue Concentrations of Clozapine and its Metabolites in the Rat
A week of daily dosing with CLZ led to no accumulation of drug in brain; a week of fluoxetine pretreatment increased analyte concentrations (serum, 86%; brain, 61%), but valproate had little effect. Expand
One hundred years of schizophrenia: A meta-analysis of the outcome literature
Overall, less than half of patients diagnosed with schizophrenia have shown substantial clinical improvement after follow-up averaging nearly 6 years, despite considerable gains in improvement rates after mid-century, there has been a decline since the 1970s. Expand
Two-year syndromal and functional recovery in 219 cases of first-episode major affective disorder with psychotic features.
OBJECTIVE Psychotic affective disorders are the most prevalent idiopathic psychoses, but their outcome from onset has rarely been studied. In this study, the authors determined the rate and latencyExpand
The McLean-Harvard First-Episode Mania Study: prediction of recovery and first recurrence.
Within 2-4 years of first lifetime hospitalization for mania, all but 2% of patients experienced syndromal recovery, but 28% remained symptomatic, only 43% achieved functional recovery, and 57% switched or had new illness episodes. Expand
Comparative postnatal development of dopamine D1, D2 and D4 receptors in rat forebrain
D1, D2 and D4 receptors follow a similar course of development in several cortical, limbic and extrapyramidal regions of rat forebrain, with selective elimination of excess dopamine receptors at the time of puberty in the caudate–putamen and accumbens but not other brain regions. Expand
The International Society for Bipolar Disorders (ISBD) task force report on antidepressant use in bipolar disorders.
A consensus was reached on 12 statements on the use of antidepressants in bipolar disorder, and antidepressants should be prescribed only as an adjunct to mood-stabilizing medications. Expand
Factors associated with treatment nonadherence among US bipolar disorder patients
Since sustained treatment‐adherence is often problematic and may limit clinical outcomes among bipolar disorder (BPD) patients, we sought risk factors to guide clinical prediction of nonadherence.
Efficacy of Antimanic Treatments: Meta-analysis of Randomized, Controlled Trials
We conducted meta-analyses of findings from randomized, placebo-controlled, short-term trials for acute mania in manic or mixed states of DSM (III–IV) bipolar I disorder in 56 drug–placeboExpand