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1-Phosphatidylinositol 3-Kinase

Known as: Type I Phosphatidylinositol Kinase, Phosphatidylinositol 3-Kinase [Chemical/Ingredient], Phosphatidylinositol-3-Kinase 
An enzyme that catalyzes the conversion of phosphatidylinositol to phosphatidylinositol 3-phosphate. This is the first committed step in the… Expand
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
Class III phosphatidylinositol 3-kinase (PI3-kinase) regulates multiple membrane trafficking. In yeast, two distinct PI3-kinase… Expand
Highly Cited
2002
Highly Cited
2002
Recent studies have demonstrated that fatty acids induce insulin resistance in skeletal muscle by blocking insulin activation of… Expand
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Review
2002
Review
2002
One signal that is overactivated in a wide range of tumour types is the production of a phospholipid, phosphatidylinositol (3,4,5… Expand
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Review
2002
Review
2002
Phosphorylated lipids are produced at cellular membranes during signaling events and contribute to the recruitment and activation… Expand
Highly Cited
1999
Highly Cited
1999
To examine the mechanism by which free fatty acids (FFA) induce insulin resistance in human skeletal muscle, glycogen, glucose-6… Expand
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Highly Cited
1998
Highly Cited
1998
Vascular endothelial growth factor (VEGF) has been found to have various functions on endothelial cells, the most prominent of… Expand
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Highly Cited
1998
Highly Cited
1998
  • M. Pap, G. Cooper
  • The Journal of Biological Chemistry
  • 1998
  • Corpus ID: 44500558
Growth factor-dependent survival of a variety of mammalian cells is dependent on the activation of phosphatidylinositol (PI) 3… Expand
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Review
1998
Review
1998
While a plethora of extracellular molecules exist that modulate cellular functions via binding to membrane receptors inside the… Expand
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Highly Cited
1996
Highly Cited
1996
Insulin activated endogenous protein kinase B alpha (also known as RAC/Akt kinase) activity 12‐fold in L6 myotubes, while after… Expand
Highly Cited
1994
Highly Cited
1994
Phosphatidylinositol (PtdIns) 3-kinase is an enzyme implicated in growth factor signal transduction by associating with receptor… Expand