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1-Phosphatidylinositol 3-Kinase

Known as: Type I Phosphatidylinositol Kinase, Phosphatidylinositol 3-Kinase [Chemical/Ingredient], Phosphatidylinositol-3-Kinase 
An enzyme that catalyzes the conversion of phosphatidylinositol to phosphatidylinositol 3-phosphate. This is the first committed step in the… Expand
National Institutes of Health

Related topics

Related topics

20 relations
1-phosphatidylinositol-3-kinase activityHomo sapiensIn BloodPIK3CA gene
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Narrower (2)

PIK3CA protein, humanPhosphoinositide-3-Kinase, Catalytic, Beta Polypeptide

Broader (1)

Phosphatidylinositol 3-Kinases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Targeting PI3K in cancer: mechanisms and advances in clinical trials
Phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling is one of the most important… Expand
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Review
2019
Review
2019
Therapeutic potentials of plant iridoids in Alzheimer's and Parkinson's diseases: A review.
Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common age-related neurodegenerative disorders, affecting… Expand
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Review
2019
Review
2019
Polyphenols in the treatment of autoimmune diseases.
In addition to protecting body from infections and diseases, the immune system produces auto-antibodies that can cause complex… Expand
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Review
2019
Review
2019
The Role of PI3K/Akt and ERK in Neurodegenerative Disorders
Disruption of Akt and Erk-mediated signal transduction significantly contributes in the pathogenesis of various neurodegenerative… Expand
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Review
2019
Review
2019
Genetics and Epigenetics of Gastroenteropancreatic Neuroendocrine Neoplasms
Abstract Gastroenteropancreatic (GEP) neuroendocrine neoplasms (NENs) are heterogeneous regarding site of origin, biological… Expand
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Review
2019
Review
2019
Emerging views of mitophagy in immunity and autoimmune diseases
ABSTRACT Mitophagy is a vital form of autophagy for selective removal of dysfunctional or redundant mitochondria. Accumulating… Expand
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Review
2018
Review
2018
The roles of metallothioneins in carcinogenesis
Metallothioneins (MTs) are small cysteine-rich proteins that play important roles in metal homeostasis and protection against… Expand
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Review
2018
Review
2018
The ERK and JNK pathways in the regulation of metabolic reprogramming
Most tumor cells reprogram their glucose metabolism as a result of mutations in oncogenes and tumor suppressors, leading to the… Expand
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Highly Cited
2002
Highly Cited
2002
Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle*
Recent studies have demonstrated that fatty acids induce insulin resistance in skeletal muscle by blocking insulin activation of… Expand
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Highly Cited
1994
Highly Cited
1994
A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).
Phosphatidylinositol (PtdIns) 3-kinase is an enzyme implicated in growth factor signal transduction by associating with receptor… Expand
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