1-Phosphatidylinositol 3-Kinase

Known as: Type I Phosphatidylinositol Kinase, Phosphatidylinositol 3-Kinase [Chemical/Ingredient], Phosphatidylinositol-3-Kinase 
An enzyme that catalyzes the conversion of phosphatidylinositol to phosphatidylinositol 3-phosphate. This is the first committed step in the… (More)
National Institutes of Health

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1-phosphatidylinositol-3-kinase activityHomo sapiensIn BloodPIK3CA gene
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Narrower (2)

PIK3CA protein, humanPhosphoinositide-3-Kinase, Catalytic, Beta Polypeptide

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Phosphatidylinositol 3-Kinases

Papers overview

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Highly Cited
2009
Highly Cited
2009
Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1–phosphatidylinositol-3-kinase complex
Beclin 1, a mammalian autophagy protein that has been implicated in development, tumour suppression, neurodegeneration and cell… (More)
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Review
2009
Review
2009
Targeting the phosphoinositide 3-kinase pathway in cancer
The phosphoinositide 3-kinase (PI3K) pathway is a key signal transduction system that links oncogenes and multiple receptor… (More)
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Highly Cited
2008
Highly Cited
2008
Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG.
Class III phosphatidylinositol 3-kinase (PI3-kinase) regulates multiple membrane trafficking. In yeast, two distinct PI3-kinase… (More)
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Review
2002
Review
2002
The phosphatidylinositol 3-Kinase–AKT pathway in human cancer
One signal that is overactivated in a wide range of tumour types is the production of a phospholipid, phosphatidylinositol (3,4,5… (More)
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Review
2002
Review
2002
The phosphoinositide 3-kinase pathway.
Phosphorylated lipids are produced at cellular membranes during signaling events and contribute to the recruitment and activation… (More)
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Highly Cited
2002
Highly Cited
2002
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle.
Recent studies have demonstrated that fatty acids induce insulin resistance in skeletal muscle by blocking insulin activation of… (More)
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Highly Cited
2000
Highly Cited
2000
Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration.
We have studied the role of phosphatidylinositol 3-OH kinase (PI3K)-Akt signaling in transforming growth factor beta (TGFbeta… (More)
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Highly Cited
1999
Highly Cited
1999
Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity.
To examine the mechanism by which free fatty acids (FFA) induce insulin resistance in human skeletal muscle, glycogen, glucose-6… (More)
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Highly Cited
1995
Highly Cited
1995
The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
The serine/threonine protein kinase encoded by the Akt proto-oncogene is catalytically inactive in serum-starved primary and… (More)
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Highly Cited
1995
Highly Cited
1995
Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor.
Nerve growth factor (NGF) induces both differentiation and survival of neurons by binding to the Trk receptor protein tyrosine… (More)
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