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1-Phosphatidylinositol 3-Kinase

Known as: Type I Phosphatidylinositol Kinase, Phosphatidylinositol 3-Kinase [Chemical/Ingredient], Phosphatidylinositol-3-Kinase 
An enzyme that catalyzes the conversion of phosphatidylinositol to phosphatidylinositol 3-phosphate. This is the first committed step in the… Expand
National Institutes of Health

Related topics

Related topics

20 relations
1-phosphatidylinositol-3-kinase activityHomo sapiensIn BloodPIK3CA gene
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Narrower (2)

PIK3CA protein, humanPhosphoinositide-3-Kinase, Catalytic, Beta Polypeptide

Broader (1)

Phosphatidylinositol 3-Kinases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG.
Class III phosphatidylinositol 3-kinase (PI3-kinase) regulates multiple membrane trafficking. In yeast, two distinct PI3-kinase… Expand
Highly Cited
2002
Highly Cited
2002
Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle*
Recent studies have demonstrated that fatty acids induce insulin resistance in skeletal muscle by blocking insulin activation of… Expand
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Review
2002
Review
2002
The phosphatidylinositol 3-Kinase–AKT pathway in human cancer
One signal that is overactivated in a wide range of tumour types is the production of a phospholipid, phosphatidylinositol (3,4,5… Expand
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Review
2002
Review
2002
The phosphoinositide 3-kinase pathway.
Phosphorylated lipids are produced at cellular membranes during signaling events and contribute to the recruitment and activation… Expand
Highly Cited
1999
Highly Cited
1999
Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity.
To examine the mechanism by which free fatty acids (FFA) induce insulin resistance in human skeletal muscle, glycogen, glucose-6… Expand
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Highly Cited
1998
Highly Cited
1998
Vascular Endothelial Growth Factor Regulates Endothelial Cell Survival through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway
Vascular endothelial growth factor (VEGF) has been found to have various functions on endothelial cells, the most prominent of… Expand
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Highly Cited
1998
Highly Cited
1998
Role of Glycogen Synthase Kinase-3 in the Phosphatidylinositol 3-Kinase/Akt Cell Survival Pathway*
  • M. Pap, G. Cooper
  • The Journal of Biological Chemistry
  • 1998
    • Corpus ID: 44500558
Growth factor-dependent survival of a variety of mammalian cells is dependent on the activation of phosphatidylinositol (PI) 3… Expand
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Review
1998
Review
1998
Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.
While a plethora of extracellular molecules exist that modulate cellular functions via binding to membrane receptors inside the… Expand
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Highly Cited
1996
Highly Cited
1996
Mechanism of activation of protein kinase B by insulin and IGF‐1.
Insulin activated endogenous protein kinase B alpha (also known as RAC/Akt kinase) activity 12‐fold in L6 myotubes, while after… Expand
Highly Cited
1994
Highly Cited
1994
A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).
Phosphatidylinositol (PtdIns) 3-kinase is an enzyme implicated in growth factor signal transduction by associating with receptor… Expand
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