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1-Phosphatidylinositol 3-Kinase

Known as: Type I Phosphatidylinositol Kinase, Phosphatidylinositol 3-Kinase [Chemical/Ingredient], Phosphatidylinositol-3-Kinase 
An enzyme that catalyzes the conversion of phosphatidylinositol to phosphatidylinositol 3-phosphate. This is the first committed step in the… 
National Institutes of Health

Related topics

Related topics

20 relations
1-phosphatidylinositol-3-kinase activityHomo sapiensIn BloodPIK3CA gene

Narrower (2)

PIK3CA protein, humanPhosphoinositide-3-Kinase, Catalytic, Beta Polypeptide

Broader (1)

Phosphatidylinositol 3-Kinases

Papers overview

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Highly Cited
2002
Highly Cited
2002
A Phosphatidylinositol 3-Kinase-independent Insulin Signaling Pathway to N-WASP/Arp2/3/F-actin Required for GLUT4 Glucose Transporter Recycling*
Recruitment of intracellular glucose transporter 4 (GLUT4) to the plasma membrane of fat and muscle cells in response to insulin… 
Highly Cited
1999
Highly Cited
1999
Leptin opposes insulin's effects on fatty acid partitioning in muscles isolated from obese ob/obmice.
Because muscle triacylglycerol (TAG) accumulation might contribute to insulin resistance in leptin-deficient ob/obmice, we… 
Review
1999
Review
1999
Signal transduction from the B cell antigen-receptor.
Highly Cited
1999
Highly Cited
1999
Cell-Extracellular Matrix Interactions Stimulate the AP-1 Transcription Factor in an Integrin-Linked Kinase- and Glycogen Synthase Kinase 3-Dependent Manner
ABSTRACT Integrin-mediated interactions of cells with components of the extracellular matrix regulate cell survival, cell… 
Highly Cited
1999
Highly Cited
1999
Evidence That a Phosphatidylinositol 3,4,5-Trisphosphate-binding Protein Can Function in Nucleus*
PIP3BP is a phosphatidylinositol 3,4,5-trisphosphate-binding protein (PIP3BP) abundant in brain, containing a zinc finger motif… 
Highly Cited
1996
Highly Cited
1996
Host signal transduction and endocytosis of Campylobacter jejuni.
Caveolae are plasma membrane invaginations found in a variety of mammalian cells and are implicated in clathrin-independent… 
Highly Cited
1996
Highly Cited
1996
Type I Insulin-like Growth Factor Receptor Activation Regulates Apoptotic Proteins*
Activation of the type I insulin-like growth factor receptor (IGF-IR) blocks osmotic mediated programmed cell death (PCD) in… 
Highly Cited
1994
Highly Cited
1994
Mutagenic analysis of the roles of SH2 and SH3 domains in regulation of the Abl tyrosine kinase
We have used in vitro mutagenesis to examine in detail the roles of two modular protein domains, SH2 and SH3, in the regulation… 
Highly Cited
1994
Highly Cited
1994
Multiple cytokines activate phosphatidylinositol 3-kinase in hemopoietic cells. Association of the enzyme with various tyrosine-phosphorylated proteins.
Highly Cited
1991
Highly Cited
1991
A phosphatidylinositol-3 kinase binds to platelet-derived growth factor receptors through a specific receptor sequence containing phosphotyrosine
Platelet-derived growth factor (PDGF) stimulates autophosphorylation of the PDGF receptor and association of the receptor with… 
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