1-Phosphatidylinositol 3-Kinase

Known as: Type I Phosphatidylinositol Kinase, Phosphatidylinositol 3-Kinase [Chemical/Ingredient], Phosphatidylinositol-3-Kinase 
An enzyme that catalyzes the conversion of phosphatidylinositol to phosphatidylinositol 3-phosphate. This is the first committed step in the… (More)
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
Beclin 1, a mammalian autophagy protein that has been implicated in development, tumour suppression, neurodegeneration and cell… (More)
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Review
2009
Review
2009
The phosphoinositide 3-kinase (PI3K) pathway is a key signal transduction system that links oncogenes and multiple receptor… (More)
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Highly Cited
2008
Highly Cited
2008
Class III phosphatidylinositol 3-kinase (PI3-kinase) regulates multiple membrane trafficking. In yeast, two distinct PI3-kinase… (More)
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Review
2002
Review
2002
One signal that is overactivated in a wide range of tumour types is the production of a phospholipid, phosphatidylinositol (3,4,5… (More)
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Review
2002
Review
2002
Phosphorylated lipids are produced at cellular membranes during signaling events and contribute to the recruitment and activation… (More)
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Highly Cited
2002
Highly Cited
2002
Recent studies have demonstrated that fatty acids induce insulin resistance in skeletal muscle by blocking insulin activation of… (More)
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Highly Cited
2000
Highly Cited
2000
We have studied the role of phosphatidylinositol 3-OH kinase (PI3K)-Akt signaling in transforming growth factor beta (TGFbeta… (More)
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Highly Cited
1999
Highly Cited
1999
To examine the mechanism by which free fatty acids (FFA) induce insulin resistance in human skeletal muscle, glycogen, glucose-6… (More)
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Highly Cited
1995
Highly Cited
1995
The serine/threonine protein kinase encoded by the Akt proto-oncogene is catalytically inactive in serum-starved primary and… (More)
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Highly Cited
1995
Highly Cited
1995
Nerve growth factor (NGF) induces both differentiation and survival of neurons by binding to the Trk receptor protein tyrosine… (More)
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