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1-Phosphatidylinositol 3-Kinase

Known as: Type I Phosphatidylinositol Kinase, Phosphatidylinositol 3-Kinase [Chemical/Ingredient], Phosphatidylinositol-3-Kinase 
An enzyme that catalyzes the conversion of phosphatidylinositol to phosphatidylinositol 3-phosphate. This is the first committed step in the… 
National Institutes of Health

Related topics

Related topics

20 relations
1-phosphatidylinositol-3-kinase activityHomo sapiensIn BloodPIK3CA gene

Narrower (2)

PIK3CA protein, humanPhosphoinositide-3-Kinase, Catalytic, Beta Polypeptide

Broader (1)

Phosphatidylinositol 3-Kinases

Papers overview

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Highly Cited
2006
Highly Cited
2006
Antitumor activity of ZSTK474, a new phosphatidylinositol 3-kinase inhibitor.
BACKGROUND We previously synthesized a novel s-triazine derivative, ZSTK474 [2-(2-difluoromethylbenzimidazol-1-yl)-4,6… 
Review
2005
Review
2005
The role of insulin receptor signaling in the brain
Highly Cited
2003
Highly Cited
2003
Prostaglandin E2 Induced Functional Expression of Early Growth Response Factor-1 by EP4, but Not EP2, Prostanoid Receptors via the Phosphatidylinositol 3-Kinase and Extracellular Signal-regulated…
Prostaglandin E2(PGE2) mediates its physiological effects by interactions with a subfamily of G-protein-coupled receptors known… 
Highly Cited
2001
Highly Cited
2001
Akt1/PKBα Is Required for Normal Growth but Dispensable for Maintenance of Glucose Homeostasis in Mice*
The serine-threonine kinase Akt, also known as protein kinase B (PKB), is an important effector for phosphatidylinositol 3-kinase… 
Highly Cited
2001
Highly Cited
2001
Prostaglandin E2 Increases Growth and Motility of Colorectal Carcinoma Cells*
Chronic use of nonsteroidal anti-inflammatory drugs results in a significant reduction of risk and mortality from colorectal… 
Highly Cited
2001
Highly Cited
2001
Roles of Phosphatidylinositol 3-Kinase in Interferon-γ-dependent Phosphorylation of STAT1 on Serine 727 and Activation of Gene Expression*
STAT1 must be phosphorylated on serine 727 to be fully active in transcription. We show that phosphatidylinositol 3-kinase (PI3K… 
Highly Cited
2000
Highly Cited
2000
Regulation of cellular growth by the Drosophila target of rapamycin dTOR.
The TOR protein kinases (TOR1 and TOR2 in yeast; mTOR/FRAP/RAFT1 in mammals) promote cellular proliferation in response to… 
Highly Cited
1999
Highly Cited
1999
Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.
Extracellular signals often result in simultaneous activation of both the Raf-MEK-ERK and PI3K-Akt pathways (where ERK is… 
Highly Cited
1992
Highly Cited
1992
Phosphatidylinositol 3-kinase: Structure and expression of the 110 kd catalytic subunit
Highly Cited
1991
Highly Cited
1991
Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase
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