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Phosphatidylinositol 3-Kinases

Known as: PtdIns 3-Kinases, PI 3-Kinase, PI-3 Kinase 
Phosphotransferases that catalyzes the conversion of 1-phosphatidylinositol to 1-phosphatidylinositol 3-phosphate. Many members of this enzyme class… 
National Institutes of Health

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1-Phosphatidylinositol 3-KinaseN24 peptide, humanPIK3C3 protein, mousePIK3CA protein, human
In BloodProcess of secretionantagonists & inhibitorsaspects of radiation effects

Papers overview

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Review
2006
Review
2006
New players in TLR-mediated innate immunicty: P13K and small Rho GTPases
Toll-like receptors (TLRs) play a crucial role in the innate immune system as a first line of defense against pathogens. TLR… 
Highly Cited
2003
Highly Cited
2003
The PI3-kinase-Akt pathway promotes mesangial cell survival and inhibits apoptosis in vitro via NF-kappa B and Bad.
While the serine/threonine protein kinase Akt has attracted attention as a mediator of survival (anti-apoptotic) signal, the… 
Highly Cited
2001
Highly Cited
2001
Role of STAT3 and PI 3-Kinase/Akt in Mediating the Survival Actions of Cytokines on Sensory Neurons
The binding of cytokines to the gp130 receptor activates the STAT3, MEK/MAPK, and PI3K/Akt signalling pathways. To assess the… 
Highly Cited
2001
Highly Cited
2001
A Critical Role for Phosphoinositide 3-Kinase Upstream of Gab1 and SHP2 in the Activation of Ras and Mitogen-activated Protein Kinases by Epidermal Growth Factor*
Although the mechanisms involved in the activation of mitogen-activated protein kinases (MAPK) by receptor tyrosine kinases do… 
Highly Cited
2001
Highly Cited
2001
Two distinct signalling pathways are involved in FGF2-stimulated proliferation of choriocapillary endothelial cells: A comparative study with VEGF
In the retina, angiogenesis is an important component of normal physiological events such as embryonic vascular development. It… 
Highly Cited
1999
Highly Cited
1999
DHEA improves glucose uptake via activations of protein kinase C and phosphatidylinositol 3-kinase.
We have examined the effect of adrenal androgen, dehydroepiandrosterone (DHEA), on glucose uptake, phosphatidylinositol (PI) 3… 
Highly Cited
1999
Highly Cited
1999
Evidence for and against a Pivotal Role of PI 3-Kinase in a Neuronal Cell Survival Pathway
PI 3-kinase has emerged as a key enzyme for regulating neuronal cell survival. However, it has not as yet been demonstrated… 
Highly Cited
1998
Highly Cited
1998
Nerve growth factor induced stimulation of Ras requires Trk interaction with Shc but does not involve phosphoinositide 3-OH kinase
The TrkA receptor protein tyrosine kinase is involved in signalling PC12 cell differentiation and cessation of cell division in… 
Highly Cited
1997
Highly Cited
1997
Insulin-Like Growth Factor and Potassium Depolarization Maintain Neuronal Survival by Distinct Pathways: Possible Involvement of PI 3-Kinase in IGF-1 Signaling
Cultured cerebellar granule neurons die by apoptosis when switched from a medium containing an elevated level of potassium (K… 
Highly Cited
1990
Highly Cited
1990
Thrombin stimulates the production of a novel polyphosphoinositide in human platelets.
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