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Phosphatidylinositol 3-Kinases

Known as: PtdIns 3-Kinases, PI 3-Kinase, PI-3 Kinase 
Phosphotransferases that catalyzes the conversion of 1-phosphatidylinositol to 1-phosphatidylinositol 3-phosphate. Many members of this enzyme class… Expand
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
Oncogenic tyrosine kinases have proved to be promising targets for the development of highly effective anticancer drugs. However… Expand
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Highly Cited
2006
Highly Cited
2006
Wound healing is essential for maintaining the integrity of multicellular organisms. In every species studied, disruption of an… Expand
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Highly Cited
2004
Highly Cited
2004
Phosphatidylinositol 3-kinases (PI3Ks) are lipid kinases that regulate signaling pathways important for neoplasia, including cell… Expand
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Highly Cited
2002
Highly Cited
2002
We have investigated the mechanisms of leading edge formation in chemotaxing Dictyostelium cells. We demonstrate that while… Expand
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Highly Cited
2001
Highly Cited
2001
Phagosomes acquire their microbicidal properties by fusion with lysosomes. Products of phosphatidylinositol 3-kinase (PI 3-kinase… Expand
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Highly Cited
2000
Highly Cited
2000
Oestrogen produces diverse biological effects through binding to the oestrogen receptor (ER). The ER is a steroid hormone nuclear… Expand
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Highly Cited
2000
Highly Cited
2000
The broad nature of insulin resistant glucose metabolism in skeletal muscle of patients with type 2 diabetes suggests a defect in… Expand
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Highly Cited
1996
Highly Cited
1996
A PHEROMONE-INDUCED neurosecretory pathway in Caenorhabditis elegans triggers developmental arrest and an increase in longevity… Expand
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Highly Cited
1995
Highly Cited
1995
A serine/threonine kinase, named protein kinase B (PKB)1 for its sequence homology to both protein kinase A and C, has previously… Expand
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Highly Cited
1995
Highly Cited
1995
The serine/threonine protein kinase encoded by the Akt proto-oncogene is catalytically inactive in serum-starved primary and… Expand
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