Phosphatidylinositol 3-Kinases

Known as: PtdIns 3-Kinases, PI 3-Kinase, PI-3 Kinase 
Phosphotransferases that catalyzes the conversion of 1-phosphatidylinositol to 1-phosphatidylinositol 3-phosphate. Many members of this enzyme class… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1990-2018
05010019902018

Papers overview

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Highly Cited
2001
Highly Cited
2001
Estrogen receptors (ERs) mediate most of the biological effects of estrogen in mammary and uterine epithelial cells by binding to… (More)
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Highly Cited
2000
Highly Cited
2000
Oestrogen produces diverse biological effects through binding to the oestrogen receptor (ER). The ER is a steroid hormone nuclear… (More)
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Highly Cited
1999
Highly Cited
1999
Activation of the nuclear transcription factor NF-κB by inflammatory cytokines requires the successive action of NF-κB-inducing… (More)
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Highly Cited
1998
Highly Cited
1998
Growth factor-dependent survival of a variety of mammalian cells is dependent on the activation of phosphatidylinositol (PI) 3… (More)
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Highly Cited
1998
Highly Cited
1998
The activities of cyclin D-dependent kinases serve to integrate extracellular signaling during G1 phase with the cell-cycle… (More)
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Highly Cited
1997
Highly Cited
1997
Upon detachment from the extracellular matrix, epithelial cells enter into programmed cell death, a phenomenon known as anoikis… (More)
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Highly Cited
1996
Highly Cited
1996
A PHEROMONE-INDUCED neurosecretory pathway in Caenorhabditis elegans triggers developmental arrest and an increase in longevity… (More)
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Highly Cited
1995
Highly Cited
1995
A serine/threonine kinase, named protein kinase B (PKB)1 for its sequence homology to both protein kinase A and C, has previously… (More)
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Highly Cited
1995
Highly Cited
1995
The serine/threonine protein kinase encoded by the Akt proto-oncogene is catalytically inactive in serum-starved primary and… (More)
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Highly Cited
1994
Highly Cited
1994
Phosphatidylinositol 3-kinase (PI 3-kinase) is stimulated by insulin and a variety of growth factors, but its exact role in… (More)
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