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PIK3CA protein, human

Known as: Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform, PI3K-Alpha, PtdIns-3-Kinase p110 
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (1068 aa, ~124 kDa) is encoded by the human PIK3CA gene. This protein… 
National Institutes of Health

Related topics

Related topics

49 relations
1-Phosphatidylinositol 3-Kinase1-phosphatidylinositol-3-kinase activityAKT Signaling PathwayAngiogenesis Pathway

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
MiR-27b targets PI3K p110α to inhibit proliferation and migration in colorectal cancer stem cell.
Colorectal cancer (CRC) is one of the leading causes of cancer deaths worldwide, CRC was estimated to be the third most commonly… 
2016
2016
MiR-422a acts as a tumor suppressor in glioblastoma by targeting PIK3CA.
Although surgical treatment, chemotherapy, and radiotherapy have improved the overall survival rate in glioblastoma multiforme… 
2015
2015
Abstract PD5-5: Phase I study of the PI3Kα inhibitor BYL719 plus fulvestrant in patients withPIK3CA-altered and wild type ER+/HER2- locally advanced or metastatic breast cancer
Background: BYL719 selectively inhibits the α-isoform of Class I PI3K. PI3Kα is encoded by PIK3CA, a frequently altered gene in… 
2015
2015
PIK3CA genotype and treatment decisions in human epidermal growth factor receptor 2-positive breast cancer.
Genotyping of patient tumors has been rapidly incorporated into both clinical trials and clinical practice over the last several… 
2013
2013
A small cog in a big wheel: PIK3CA mutations in colorectal cancer.
Phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit alpha (PI3KCA) is encoded by the PIK3CA gene and catalyzes the… 
2011
2011
Mutations of the catalytic subunit a of PI3K (PIK3CA) in erlotinib-treated non-small cell lung cancer (NSCLC) patients (p) with epidermal growth factor receptor (EGFR) mutations.
7588 Background: Stage IV NSCLC p with EGFR mutations treated with erlotinib had a median progression-free survival (PFS) of 14… 
2011
2011
PIK3CA mutations and EGFR overexpression predict for lithium sensitivity in human breast epithelial cells
A high frequency of somatic mutations has been found in breast cancers within the gene encoding the catalytic p110α subunit of… 
2009
2009
Infrequent occurrence of PIK3CA mutations in chronic lymphocytic leukemia
The phosphoinositide 3-kinase (PI3K) pathway is central to many different cell signalling pathways associated with cell growth… 
2006
2006
PKCalpha reduces the lipid kinase activity of the p110alpha/p85alpha PI3K through the phosphorylation of the catalytic subunit.
The modulation of phosphoinositide 3-kinase (PI3K) activity influences the quality of cellular responses triggered by various… 
2004
2004
Over-expression of the p110beta but not p110alpha isoform of PI 3-kinase inhibits motility in breast cancer cells.
Phosphoinositide 3-kinase (PI 3-kinase) activity is required for growth factor-induced cytoskeletal regulation and cell migration… 
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