PIK3CA protein, human

Known as: Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform, PI3K-Alpha, PtdIns-3-Kinase p110 
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (1068 aa, ~124 kDa) is encoded by the human PIK3CA gene. This protein… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1996-2018
05019962018

Papers overview

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Highly Cited
2009
Highly Cited
2009
Dysregulation of the phosphatidylinositol 3-kinase (PI3K) signaling pathway occurs frequently in human cancer. PTEN tumor… (More)
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Highly Cited
2006
Highly Cited
2006
The PIK3CA gene, coding for the catalytic subunit p110alpha of class IA phosphatidylinositol 3-kinases (PI3Ks), is frequently… (More)
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Highly Cited
2006
Highly Cited
2006
Phosphoinositide 3-kinases (PI3-Ks) are an important emerging class of drug targets, but the unique roles of PI3-K isoforms… (More)
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Highly Cited
2005
Highly Cited
2005
PIK3CA is mutated in diverse human cancers, but the functional effects of these mutations have not been defined. To evaluate the… (More)
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Highly Cited
2005
Highly Cited
2005
Deregulation of the phosphatidylinositol 3-kinase (PI3K) pathway either through loss of PTEN or mutation of the catalytic subunit… (More)
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Highly Cited
2005
Highly Cited
2005
Mutations in the PIK3CA gene, which encodes the p110alpha catalytic subunit of phosphatidylinositol 3-kinase (PI3K), have been… (More)
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Highly Cited
2005
Highly Cited
2005
Activation of the phosphoinositide 3-kinase (PI3K) pathway has been implicated in the pathogenesis of a variety of cancers… (More)
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Highly Cited
2005
Highly Cited
2005
Phosphatidylinositol 3-kinases (PI3Ks) are a group of lipid kinases that regulate signaling pathways involved in cell… (More)
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Highly Cited
2004
Highly Cited
2004
The phosphatidylinositol 3-kinases (PI3Ks) are known regulators of cellular growth and proliferation. It has recently been… (More)
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Highly Cited
2000
Highly Cited
2000
Amplification of chromosome arm 3q is the most consistent aberration in cervical cancer, and is implicated in the progression of… (More)
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