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α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro
α-Synuclein and Aging Transgenic α-synuclein can reverse the otherwise lethal neurodegeneration of cysteine string protein-α knockout mice via changes in SNARE proteins, which mediate synapticExpand
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Different neurotrophins are expressed and act in a developmental sequence to promote the survival of embryonic sensory neurons.
To investigate if different neurotrophins regulate the survival of neurons at successive developmental stages, we studied the effect of nerve growth factor (NGF), brain-derived neurotrophic factorExpand
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Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase
Neurturin (NTN) is a recently identified homologue of glial-cell-line-derived neurotrophic factor (GDNF). Both factors promote the survival of a variety of neurons, and GDNF is required for theExpand
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GDNF is an age-specific survival factor for sensory and autonomic neurons
Glial cell line-derived neurotrophic factor (GDNF) promotes the survival of two populations of CNS neurons: motoneurons and midbrain dopaminergic neurons. To see whether GDNF promotes the survival ofExpand
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Autoantibodies to alpha‐synuclein in inherited Parkinson’s disease
Neurodegeneration in Parkinson’s disease (PD) is accompanied by a local immune reaction in the affected brain regions. It is well established that α‐synuclein is directly implicated in theExpand
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Expression and function of TrkB variants in developing sensory neurons.
Mouse trigeminal neurons survive independently of neurotrophins when their axons are growing to their targets, and are then transiently supported by BDNF before becoming NGF dependent. During theExpand
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Role of PI 3-kinase, Akt and Bcl-2–related proteins in sustaining the survival of neurotrophic factor–independent adult sympathetic neurons
By adulthood, sympathetic neurons have lost dependence on NGF and NT-3 and are able to survive in culture without added neurotrophic factors. To understand the molecular mechanisms that sustain adultExpand
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Organization, expression and polymorphism of the human persyn gene.
Persyn is a recently identified member of the synuclein family with a distinct pattern of expression during pre- and postnatal development of the mouse peripheral and central nervous systems. As withExpand
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GFRα-4 and the tyrosine kinase Ret form a functional receptor complex for persephin
Abstract Glial-cell-line-derived neurotrophic factor (GDNF) [1], neurturin [2] and persephin [3] are structurally related, secreted proteins that are widely expressed in the nervous system and otherExpand
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α-Synuclein and dopamine at the crossroads of Parkinson's disease
α-Synuclein is central to the Lewy body neuropathology of Parkinson's disease (PD), a devastating neurodegenerative disorder characterized by numerous motor and non-motor manifestations. The cardinalExpand
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