Thrombin stimulates the production of a novel polyphosphoinositide in human platelets.

@article{Nolan1990ThrombinST,
  title={Thrombin stimulates the production of a novel polyphosphoinositide in human platelets.},
  author={Richard A. Nolan and Eduardo G. Lapetina},
  journal={The Journal of biological chemistry},
  year={1990},
  volume={265 5},
  pages={
          2441-5
        }
}
The sequential actions of phosphoinositide 4-kinase and 5-kinase and hydrolysis of phosphatidylinositol (PtdIns) 4,5-P2 are stimulated during platelet activation. Recently, a phosphoinositide 3-kinase has been implicated in signal transduction in several cell types. Stimulation of PtdIns(3,4)P2 synthesis has been shown in polyoma middle T-transformed and platelet-derived growth factor-stimulated cells, and this novel lipid has been implicated in signal transduction and regulation of cell… CONTINUE READING

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