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PIK3CA gene

Known as: PI3K-ALPHA, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha, p110-ALPHA 
This gene is involved in apoptosis, cell growth and angiogenesis.
National Institutes of Health

Related topics

Related topics

12 relations
1-Phosphatidylinositol 3-Kinase1-phosphatidylinositol-3-kinase activityClass Ia Phosphatidylinositol 3-Kinase, p110alpha SubunitPI4KA gene

Papers overview

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Highly Cited
2015
Highly Cited
2015
Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity
Breast cancer is the most frequent cancer in women and consists of heterogeneous types of tumours that are classified into… 
Highly Cited
2014
Highly Cited
2014
Comparative genomic hybridisation array and DNA sequencing to direct treatment of metastatic breast cancer: a multicentre, prospective trial (SAFIR01/UNICANCER).
Highly Cited
2012
Highly Cited
2012
Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA)
The p110α catalytic subunit (PIK3CA) is one of the most frequently mutated genes in cancer. We have examined the activation of… 
Highly Cited
2010
Highly Cited
2010
Prevalence and Heterogeneity of KRAS, BRAF, and PIK3CA Mutations in Primary Colorectal Adenocarcinomas and Their Corresponding Metastases
Purpose: Epidermal growth factor receptor (EGFR) antibody therapy is established in patients with wild-type KRAS colorectal… 
Highly Cited
2009
Highly Cited
2009
PIK3CA Mutations Are Not a Major Determinant of Resistance to the Epidermal Growth Factor Receptor Inhibitor Cetuximab in Metastatic Colorectal Cancer
Purpose: It has been reported that activating KRAS mutations negatively affect response to anti–epidermal growth factor receptor… 
Highly Cited
2008
Highly Cited
2008
Clinicopathological analysis of papillary thyroid cancer with PIK3CA alterations in a Middle Eastern population.
CONTEXT Genetic aberration in phosphatidylinositol 3-kinase (PI3K)/AKT pathway has been detected in numerous and diverse human… 
Highly Cited
2007
Highly Cited
2007
Oncogenic PIK3CA mutations occur in epidermal nevi and seborrheic keratoses with a characteristic mutation pattern
Activating mutations of the p110 α subunit of PI3K (PIK3CA) oncogene have been identified in a broad spectrum of malignant tumors… 
Highly Cited
2006
Highly Cited
2006
PIK3CA mutation status in Japanese lung cancer patients.
Highly Cited
2005
Highly Cited
2005
Frequent Mutation of the PIK3CA Gene in Ovarian and Breast Cancers
Purpose: Activation of the phosphatidylinositol 3-kinase (PI3K)-AKT pathway, resulting in increased cell proliferation, survival… 
Highly Cited
2005
Highly Cited
2005
Somatic mutation and gain of copy number of PIK3CA in human breast cancer
IntroductionPhosphatidylinositol 3-kinases (PI3Ks) are a group of lipid kinases that regulate signaling pathways involved in cell… 
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