PIK3CA gene

Known as: PI3K-ALPHA, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha, p110-ALPHA 
This gene is involved in apoptosis, cell growth and angiogenesis.
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
BACKGROUND Following the discovery that mutant KRAS is associated with resistance to anti-epidermal growth factor receptor (EGFR… (More)
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Highly Cited
2009
Highly Cited
2009
The monoclonal antibodies (moAb) panitumumab and cetuximab target the epidermal growth factor receptor (EGFR) and have proven… (More)
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Highly Cited
2008
Highly Cited
2008
Phosphatidylinositol 3-kinase (PI3K)/AKT pathway aberrations are common in cancer. By applying mass spectroscopy-based sequencing… (More)
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Highly Cited
2008
Highly Cited
2008
We investigated the frequency and function of mutations and increased copy number of the PIK3CA gene in lung cancers. PIK3CA… (More)
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Highly Cited
2008
Highly Cited
2008
Cetuximab is a monoclonal antibody that targets the human epidermal growth factor receptor (EGFR). Although approved for use in… (More)
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Highly Cited
2006
Highly Cited
2006
The PIK3CA gene, coding for the catalytic subunit p110alpha of class IA phosphatidylinositol 3-kinases (PI3Ks), is frequently… (More)
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Highly Cited
2005
Highly Cited
2005
The phosphatidylinositol 3'-kinase (PI3K) pathway is frequently activated in thyroid carcinomas through the constitutive… (More)
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Highly Cited
2004
Highly Cited
2004
Phosphatidylinositol 3-kinases (PI3Ks) are lipid kinases that regulate signaling pathways important for neoplasia, including cell… (More)
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Highly Cited
2004
Highly Cited
2004
Phosphatidylinositol 3'-kinases are lipid kinases with important roles in neoplasia. Recently, a very high frequency of somatic… (More)
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Highly Cited
1999
Highly Cited
1999
Ovarian cancer is the leading cause of death from gynecological malignancy and the fourth leading cause of cancer death among… (More)
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