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EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy
Receptor tyrosine kinase genes were sequenced in non–small cell lung cancer (NSCLC) and matched normal tissue. Somatic mutations of the epidermal growth factor receptor gene EGFR were found in 15of… Expand
Characterizing the cancer genome in lung adenocarcinoma
Somatic alterations in cellular DNA underlie almost all human cancers. The prospect of targeted therapies and the development of high-resolution, genome-wide approaches are now spurring systematic… Expand
Involvement of Histone H1.2 in Apoptosis Induced by DNA Double-Strand Breaks
It is poorly understood how apoptotic signals arising from DNA damage are transmitted to mitochondria, which release apoptogenic factors into the cytoplasm that activate downstream destruction… Expand
miR-206 Expression is down-regulated in estrogen receptor alpha-positive human breast cancer.
- N. Kondo, Tatsuya Toyama, H. Sugiura, Y. Fujii, H. Yamashita
- Biology, Medicine
- Cancer research
- 15 January 2009
Expression levels of estrogen receptor (ER) alpha govern estrogen-dependent growth, response to endocrine therapy, and prognosis in ERalpha-positive breast cancer. Multiple mechanisms involved in… Expand
Impact and predictors of acute exacerbation of interstitial lung diseases after pulmonary resection for lung cancer.
- T. Satō, S. Teramukai, +12 authors H. Date
- The Journal of thoracic and cardiovascular…
- 1 May 2014
OBJECTIVE The study objective was to examine the incidence, risk factors, and mortality rate of acute exacerbation of interstitial lung diseases in patients with lung cancer undergoing pulmonary… Expand
Met gene copy number predicts the prognosis for completely resected non‐small cell lung cancer
The Met oncogene encodes the tyrosine kinase receptor for hepatocyte growth factor (HGF). Uncontrolled activation of Met is oncogenic and has been implicated in the growth, invasion and metastasis in… Expand
Expression, Function, and Clinical Implications of the Estrogen Receptor β in Human Lung Cancers
Abstract The higher frequency of human lung adenocarcinoma in females than in males, strongly suggests the involvement of gender dependent factors in the etiology of this disease. This is the first… Expand
Japanese Lung Cancer Registry Study of 11,663 Surgical Cases in 2004: Demographic and Prognosis Changes Over Decade
- N. Sawabata, E. Miyaoka, +7 authors K. Yokoi
- Journal of thoracic oncology : official…
- 1 July 2011
Background: The Japan Lung Cancer Society, the Japanese Association for Chest Surgery, and the Japanese Respiratory Society jointly established the Japanese Joint Committee for Lung Cancer… Expand
microRNA expression profile in undifferentiated gastric cancer.
Prognosis of patients with undifferentiated gastric cancer is generally poor. The expression of various microRNAs (miRNAs) has not been comprehensively investigated in undifferentiated gastric… Expand
Stat5 expression predicts response to endocrine therapy and improves survival in estrogen receptor-positive breast cancer.
- Hideki Yamashita, M. Nishio, +6 authors H. Iwase
- Biology, Medicine
- Endocrine-related cancer
- 15 April 2006
Constitutively activated signal transducers and activators of transcription (Stats), in particular Stat3 and Stat5, have been demonstrated to directly contribute to oncogenesis by stimulating cell… Expand