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EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy
Receptor tyrosine kinase genes were sequenced in non–small cell lung cancer (NSCLC) and matched normal tissue. Somatic mutations of the epidermal growth factor receptor gene EGFR were found in 15ofExpand
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Characterizing the cancer genome in lung adenocarcinoma
Somatic alterations in cellular DNA underlie almost all human cancers. The prospect of targeted therapies and the development of high-resolution, genome-wide approaches are now spurring systematicExpand
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Involvement of Histone H1.2 in Apoptosis Induced by DNA Double-Strand Breaks
It is poorly understood how apoptotic signals arising from DNA damage are transmitted to mitochondria, which release apoptogenic factors into the cytoplasm that activate downstream destructionExpand
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miR-206 Expression is down-regulated in estrogen receptor alpha-positive human breast cancer.
Expression levels of estrogen receptor (ER) alpha govern estrogen-dependent growth, response to endocrine therapy, and prognosis in ERalpha-positive breast cancer. Multiple mechanisms involved inExpand
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Impact and predictors of acute exacerbation of interstitial lung diseases after pulmonary resection for lung cancer.
OBJECTIVE The study objective was to examine the incidence, risk factors, and mortality rate of acute exacerbation of interstitial lung diseases in patients with lung cancer undergoing pulmonaryExpand
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Met gene copy number predicts the prognosis for completely resected non‐small cell lung cancer
The Met oncogene encodes the tyrosine kinase receptor for hepatocyte growth factor (HGF). Uncontrolled activation of Met is oncogenic and has been implicated in the growth, invasion and metastasis inExpand
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Expression, Function, and Clinical Implications of the Estrogen Receptor β in Human Lung Cancers
Abstract The higher frequency of human lung adenocarcinoma in females than in males, strongly suggests the involvement of gender dependent factors in the etiology of this disease. This is the firstExpand
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Japanese Lung Cancer Registry Study of 11,663 Surgical Cases in 2004: Demographic and Prognosis Changes Over Decade
Background: The Japan Lung Cancer Society, the Japanese Association for Chest Surgery, and the Japanese Respiratory Society jointly established the Japanese Joint Committee for Lung CancerExpand
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microRNA expression profile in undifferentiated gastric cancer.
Prognosis of patients with undifferentiated gastric cancer is generally poor. The expression of various microRNAs (miRNAs) has not been comprehensively investigated in undifferentiated gastricExpand
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Stat5 expression predicts response to endocrine therapy and improves survival in estrogen receptor-positive breast cancer.
Constitutively activated signal transducers and activators of transcription (Stats), in particular Stat3 and Stat5, have been demonstrated to directly contribute to oncogenesis by stimulating cellExpand
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