Protective actions of human recombinant basic fibroblast growth factor on MPTP-lesioned nigrostriatal dopamine neurons after intraventricular infusion

@article{Chadi2004ProtectiveAO,
  title={Protective actions of human recombinant basic fibroblast growth factor on MPTP-lesioned nigrostriatal dopamine neurons after intraventricular infusion},
  author={Gerson Chadi and Arbuthnott Er and Lars Ros{\'e}n and Ann Marie Janson and L. Agnati and Menek Goldstein and Sven Ove Ögren and Ralf F. Pettersson and Kjell Fuxe},
  journal={Experimental Brain Research},
  year={2004},
  volume={97},
  pages={145-158},
  url={https://api.semanticscholar.org/CorpusID:10649518}
}
Results indicate that hrFGF-2, directly and/or indirectly via astroglia, upon i.v.t. infusion exerts trophic effects on the nigrostriatal DA system and may increase survival of nigrostRIatal DA nerve cells exposed to the MPTP neurotoxin.
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64 References

Basic FGF reverses chemical and morphological deficits in the nigrostriatal system of MPTP-treated mice

The results suggest that bFGF partially prevents the deleterious chemical and morphological consequences of an MPTP-mediated nigrostriatal lesion and mimics at least the morphological effects of chromaffin cell grafts to theMPTP-lesioned brain.

FGF‐2‐mediated protection of cultured mesencephalic dopaminergic neurons against MPTP and MPP+: Specificity and impact of culture conditions, non‐dopaminergic neurons, and astroglial cells

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Evidence for a protective action of the vigilance promoting drug Modafinil on the MPTP-induced degeneration of the nigrostriatal dopamine neurons in the black mouse: an immunocytochemical and biochemical analysis

SummaryBased on the observations that the psychostimulant drug amphetamine in combination with physiotherapy can promote recovery of brain function after brain injury, we have studied the ability of…

Expression of acidic and basic fibroblast growth factors in the substantia nigra of rat, monkey, and human.

RNA and immunoblot analysis confirmed the presence of both aFGF and bFGF mRNAs and proteins in the substantia nigra of rat, monkey, and human.

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