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Vascular endothelial growth factor B, a novel growth factor for endothelial cells.
TLDR
The results suggest that VEGF-B has a role in angiogenesis and endothelial cell growth, particularly in muscle. Expand
A SNAIL1–SMAD3/4 transcriptional repressor complex promotes TGF-β mediated epithelial–mesenchymal transition
TLDR
It is proposed that activation of a SNAIL1–SMAD3/4 transcriptional complex represents a mechanism of gene repression during EMT, which is essential for organogenesis and is triggered during carcinoma progression to an invasive state. Expand
Genes for epidermal growth factor receptor, transforming growth factor alpha, and epidermal growth factor and their expression in human gliomas in vivo.
TLDR
Several mechanisms for the activation of the EGFR-mediated growth stimulating pathway are possible in human gliomas in vivo: expression of a structurally altered receptor that may have escaped normal control mechanisms; and/or auto- juxta- or paracrine stimulating mechanisms involving coexpression of receptor and ligands, with or without overexpression of the receptor. Expand
Entry of Bunyaviruses into Mammalian Cells
TLDR
It is indicated that Uukuniemi virus penetrates host cells by acid-activated membrane fusion from late endosomal compartments, and the importance of the degradative branch of the endocytic pathway in facilitating entry of late-penetrating viruses is highlighted. Expand
Comparative localization of fibroblast growth factor receptor‐1, ‐2, and ‐3 mRNAs in the rat brain: In situ hybridization analysis
TLDR
Findings showed that these three FGF receptors exist in all subtypes of cells of each brain region, and apparent cellular specificity suggests that these receptor subtypes can have a differential trophic role in the brain, reflecting the various biological activities shown by the ligands of the FGF family. Expand
Host-derived 5' ends and overlapping complementary 3' ends of the two mRNAs transcribed from the ambisense S segment of Uukuniemi virus
TLDR
To the authors' knowledge, this is the first example of overlapping complementary mRNAs in viruses with an ambisense coding strategy, and because of a short palindromic sequence in the intergenic region, the 3' ends of both m RNAs can be folded into an A/U-rich hairpin structure. Expand
Reverse Genetics System for Uukuniemi Virus (Bunyaviridae): RNA Polymerase I-Catalyzed Expression of Chimeric Viral RNAs
TLDR
The development of a reverse genetics system for the phlebovirus Uukuniemi virus by using RNA polymerase I (pol I)-mediated transcription is described, demonstrating that the RNA pol I system, originally developed for influenza virus, has strong potential for the development of an efficient reverse Genetics system also for Bunyaviridae members, which replicate in the cytoplasm. Expand
Coexpression of the membrane glycoproteins G1 and G2 of Hantaan virus is required for targeting to the Golgi complex.
TLDR
The results indicate that for transport out of the endoplasmic reticulum and proper targeting to the Golgi complex, the two glycoproteins have to be coexpressed. Expand
Coxsackievirus and adenovirus receptor (CAR) is expressed in male germ cells and forms a complex with the differentiation factor JAM-C in mouse testis.
TLDR
The results suggest that CAR in spermatozoa is inaccessible to adenovirus-based gene therapy vectors, and that the risk of germ line infection therefore is low. Expand
Insights into bunyavirus architecture from electron cryotomography of Uukuniemi virus
TLDR
The genome, incorporated as a complex with the nucleoprotein inside the virions, was seen as a thread-like structure partially interacting with the viral membrane, and lateral interactions between the two membrane glycoproteins determine the structure of the viral particles. Expand
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