GABA: a cotransmitter linking leptin to obesity prevention.

@article{Stanley2012GABAAC,
  title={GABA: a cotransmitter linking leptin to obesity prevention.},
  author={Billy Glenn Stanley},
  journal={Endocrinology},
  year={2012},
  volume={153 5},
  pages={
          2057-8
        },
  url={https://api.semanticscholar.org/CorpusID:26791297}
}
The key behavioral findings were that the experimental mice exhibited mild but significant overeating, obesity, and had reduced energy expenditure as suggested by theildreduction in O2consumption during the night phase of the light-dark cycle.
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5 Citations

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The results demonstrate that GABA plays an important role in mediating leptin action and suggest that, under the experimental conditions, GABA release from leptin-excited neuron dominates over leptin-inhibited ones.

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These mice with an AgRP neuron–specific deletion of vesicular GABA transporter are lean, resistant to obesity and have an attenuated hyperphagic response to ghrelin, indicating that GABA release from AgRP neurons is important in regulating energy balance.