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Obesity is associated with macrophage accumulation in adipose tissue.
TLDR
Transcript expression in perigonadal adipose tissue from groups of mice in which adiposity varied due to sex, diet, and the obesity-related mutations agouti (Ay) and obese (Lepob) found that the expression of 1,304 transcripts correlated significantly with body mass.
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CCR2 modulates inflammatory and metabolic effects of high-fat feeding.
TLDR
The data suggest that CCR2 influences the development of obesity and associated adipose tissue inflammation and systemic insulin resistance and plays a role in the maintenance of adipOSE tissue macrophages and insulin resistance once obesity and its metabolic consequences are established.
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Changes in energy expenditure resulting from altered body weight.
TLDR
Maintenance of a reduced or elevated body weight is associated with compensatory changes in energy expenditure, which oppose the maintenance of a body weight that is different from the usual weight, which may account for the poor long-term efficacy of treatments for obesity.
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Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons
TLDR
Induced pluripotent stem cells are generated from an 82-year-old woman diagnosed with a familial form of amyotrophic lateral sclerosis and were successfully directed to differentiate into motor neurons, the cell type destroyed in ALS.
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The Long-Term Stability of the Human Gut Microbiota
TLDR
Low-error sequencing data suggest that initial microbial colonizers of infant guts could persist over the life span of an individual, and members of Bacteroidetes and Actinobacteria are significantly more stable components than the population average.
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Obesity and leptin resistance: distinguishing cause from effect
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Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity.
TLDR
It is concluded that orally ingested curcumin reverses many of the inflammatory and metabolic derangements associated with obesity and improves glycemic control in mouse models of type 2 diabetes.
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Waist circumference and cardiometabolic risk: a consensus statement from Shaping America's Health: Association for Weight Management and Obesity Prevention; NAASO, The Obesity Society; the American…
TLDR
A panel of members with expertise in obesity management, obesity-related epidemiology, adipose tissue metabolic pathophysiology, statistics, and nutrition science was convened, to review the published scientific literature and hear presentations from other experts in these fields.
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Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli.
TLDR
Following weight loss, there were predictable changes in neural activity, many of which were reversed by leptin, in brain areas known to be involved in the regulatory, emotional, and cognitive control of food intake, consistent with a model of the weight-reduced state as one of relative leptin deficiency.
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Waist Circumference and Cardiometabolic Risk: A Consensus Statement from Shaping America's Health: Association for Weight Management and Obesity Prevention; NAASO, The Obesity Society; the American…
TLDR
An expert panel, organized by the National Heart, Lung and Blood Institute, has recommended that WC be measured as part of the initial assessment and be used to monitor the efficacy of weight loss therapy in overweight and obese patients who have a BMI 35 kg/m.
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