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- Publications
- Influence
Obesity is associated with macrophage accumulation in adipose tissue.
- S. Weisberg, D. Mccann, M. Desai, M. Rosenbaum, R. Leibel, A. Ferrante
- Biology, Medicine
- The Journal of clinical investigation
- 15 December 2003
Obesity alters adipose tissue metabolic and endocrine function and leads to an increased release of fatty acids, hormones, and proinflammatory molecules that contribute to obesity associated… Expand
CCR2 modulates inflammatory and metabolic effects of high-fat feeding.
- S. Weisberg, D. Hunter, +6 authors A. Ferrante
- Biology, Medicine
- The Journal of clinical investigation
- 4 January 2006
The C-C motif chemokine receptor-2 (CCR2) regulates monocyte and macrophage recruitment and is necessary for macrophage-dependent inflammatory responses and the development of atherosclerosis.… Expand
Changes in energy expenditure resulting from altered body weight.
- R. Leibel, M. Rosenbaum, J. Hirsch
- Medicine
- The New England journal of medicine
- 9 March 1995
BACKGROUND
No current treatment for obesity reliably sustains weight loss, perhaps because compensatory metabolic processes resist the maintenance of the altered body weight. We examined the effects… Expand
The Long-Term Stability of the Human Gut Microbiota
Background Understanding the dynamics and stability of the human gut microbiota is important if its characterization is to play a role in the diagnosis, treatment, and prevention of disease. To… Expand
Generation of pluripotent stem cells from patients with type 1 diabetes
- R. Maehr, S. Chen, +5 authors D. Melton
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 15 September 2009
Type 1 diabetes (T1D) is the result of an autoimmune destruction of pancreatic β cells. The cellular and molecular defects that cause the disease remain unknown. Pluripotent cells generated from… Expand
Waist Circumference and Cardiometabolic Risk: A Consensus Statement from Shaping America's Health: Association for Weight Management and Obesity Prevention; NAASO, The Obesity Society; the American…
- S. Klein, D. Allison, +4 authors R. Kahn
- Medicine
- Obesity
- 1 May 2007
Introduction Obesity is an important risk factor for cardiometabolic diseases, including diabetes, hypertension, dyslipidemia, and coronary heart disease (CHD). Several leading national and… Expand
Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity.
- S. Weisberg, R. Leibel, D. Tortoriello
- Biology, Medicine
- Endocrinology
- 1 July 2008
Obesity is a major risk factor for the development of type 2 diabetes, and both conditions are now recognized to possess significant inflammatory components underlying their pathophysiologies. We… Expand
Obesity and leptin resistance: distinguishing cause from effect
- M. Myers, R. Leibel, R. Seeley, M. Schwartz
- Biology, Medicine
- Trends in Endocrinology & Metabolism
- 1 November 2010
Because leptin reduces food intake and body weight, the coexistence of elevated leptin levels with obesity is widely interpreted as evidence of 'leptin resistance.' Indeed, obesity promotes a number… Expand
Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight.
- M. Rosenbaum, R. Goldsmith, +7 authors R. Leibel
- Biology, Medicine
- The Journal of clinical investigation
- 1 December 2005
Maintenance of a reduced body weight is accompanied by decreased energy expenditure that is due largely to increased skeletal muscle work efficiency. In addition, decreased sympathetic nervous system… Expand
Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli.
- M. Rosenbaum, Melissa Sy, K. Pavlovich, R. Leibel, J. Hirsch
- Medicine
- The Journal of clinical investigation
- 1 July 2008
Increased hunger and food intake during attempts to maintain weight loss are a critical problem in clinical management of obesity. To determine whether reduced body weight maintenance is accompanied… Expand