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Obesity is associated with macrophage accumulation in adipose tissue.
Obesity alters adipose tissue metabolic and endocrine function and leads to an increased release of fatty acids, hormones, and proinflammatory molecules that contribute to obesity associatedExpand
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CCR2 modulates inflammatory and metabolic effects of high-fat feeding.
The C-C motif chemokine receptor-2 (CCR2) regulates monocyte and macrophage recruitment and is necessary for macrophage-dependent inflammatory responses and the development of atherosclerosis.Expand
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Changes in energy expenditure resulting from altered body weight.
BACKGROUND No current treatment for obesity reliably sustains weight loss, perhaps because compensatory metabolic processes resist the maintenance of the altered body weight. We examined the effectsExpand
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The Long-Term Stability of the Human Gut Microbiota
Background Understanding the dynamics and stability of the human gut microbiota is important if its characterization is to play a role in the diagnosis, treatment, and prevention of disease. ToExpand
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Generation of pluripotent stem cells from patients with type 1 diabetes
  • R. Maehr, S. Chen, +5 authors D. Melton
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 15 September 2009
Type 1 diabetes (T1D) is the result of an autoimmune destruction of pancreatic β cells. The cellular and molecular defects that cause the disease remain unknown. Pluripotent cells generated fromExpand
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Waist Circumference and Cardiometabolic Risk: A Consensus Statement from Shaping America's Health: Association for Weight Management and Obesity Prevention; NAASO, The Obesity Society; the American
Introduction Obesity is an important risk factor for cardiometabolic diseases, including diabetes, hypertension, dyslipidemia, and coronary heart disease (CHD). Several leading national andExpand
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Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity.
Obesity is a major risk factor for the development of type 2 diabetes, and both conditions are now recognized to possess significant inflammatory components underlying their pathophysiologies. WeExpand
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Obesity and leptin resistance: distinguishing cause from effect
Because leptin reduces food intake and body weight, the coexistence of elevated leptin levels with obesity is widely interpreted as evidence of 'leptin resistance.' Indeed, obesity promotes a numberExpand
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Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight.
Maintenance of a reduced body weight is accompanied by decreased energy expenditure that is due largely to increased skeletal muscle work efficiency. In addition, decreased sympathetic nervous systemExpand
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Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli.
Increased hunger and food intake during attempts to maintain weight loss are a critical problem in clinical management of obesity. To determine whether reduced body weight maintenance is accompaniedExpand
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