Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

@article{Cowley2001LeptinAA,
  title={Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus},
  author={M. Cowley and J. L. Smart and M. Rubinstein and Marcelo G. Cerd{\'a}n and S. Diano and T. Horvath and R. Cone and M. Low},
  journal={Nature},
  year={2001},
  volume={411},
  pages={480-484}
}
The administration of leptin to leptin-deficient humans, and the analogous Lepob/Lepob mice, effectively reduces hyperphagia and obesity. But common obesity is associated with elevated leptin, which suggests that obese humans are resistant to this adipocyte hormone. In addition to regulating long-term energy balance, leptin also rapidly affects neuronal activity. Proopiomelanocortin (POMC) and neuropeptide-Y types of neurons in the arcuate nucleus of the hypothalamus are both principal sites of… Expand
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