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Central nervous system control of food intake
TLDR
A model is described that delineates the roles of individual hormonal and neuropeptide signalling pathways in the control of food intake and the means by which obesity can arise from inherited or acquired defects in their function. Expand
Obesity is associated with hypothalamic injury in rodents and humans.
TLDR
Obesity is associated with neuronal injury in a brain area crucial for body weight control in both humans and rodent models, and evidence of increased gliosis in the mediobasal hypothalamus of obese humans is found. Expand
Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons
TLDR
These findings suggest that hypothalamic NPY/Agrp neurons constitute a unique cell type that is activated by fasting to stimulate food intake via a simultaneous increase of NPY and decrease of melanocortin. Expand
Central nervous system control of food intake and body weight
TLDR
This new information provides a biological context within which to consider the global obesity epidemic and identifies numerous potential avenues for therapeutic intervention and future research. Expand
STAT3 signalling is required for leptin regulation of energy balance but not reproduction
TLDR
It is shown that, like db/db mice, leprS1138 homozygotes (s/s) are hyperphagic and obese, however, whereas db/ db mice are infertile, short and diabetic, s/s mice are fertile, long and less hyperglycaemic. Expand
Identification of targets of leptin action in rat hypothalamus.
TLDR
The findings suggest that leptin action in rat hypothalamus involves altered expression of key neuropeptide genes, and implicate leptin in the hypothalamic response to fasting. Expand
Signals that regulate food intake and energy homeostasis.
TLDR
This review focuses on the molecular signals that modulate food intake while integrating the body's immediate and long-term energy needs. Expand
Leptin Increases Hypothalamic Pro-opiomelanocortin mRNA Expression in the Rostral Arcuate Nucleus
TLDR
The finding that leptin reverses this effect in ob/ob, but not db/db, mice suggests that leptin stimulates arcuate nucleus POMC gene expression via a pathway involving leptin receptors, and supports the hypothesis that leptin signaling in the brain involves activation of the hypothalamic melanocortin system. Expand
Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans
TLDR
It is hypothesized that a saturable mechanism mediates CSF leptin transport, and that reduced efficiency of brain leptin delivery among obese individuals with high plasma leptin levels results in apparent leptin resistance. Expand
Intracellular signalling: Key enzyme in leptin-induced anorexia
TLDR
It is shown that systemic administration of leptin in rats activates the enzyme phosphatidylinositol-3-OH kinase in the hypothalamus and that intracerebro-ventricular infusion of inhibitors of this enzyme prevents leptin-induced anorexia. Expand
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