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Long-Term implications of early onset in bipolar disorder: data from the first 1000 participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD)
TLDR
Very early or early onset of bipolar disorder might herald a more severe disease course in terms of chronicity and comorbidity and whether early intervention might modify this risk merits further investigation. Expand
The functional neuroanatomy of bipolar disorder: a review of neuroimaging findings
TLDR
These studies suggest that, in bipolar disorder, there may be diminished prefrontal modulation of subcortical and medial temporal structures within the anterior limbic network that results in dysregulation of mood. Expand
Reliability of the Washington University in St. Louis Kiddie Schedule for Affective Disorders and Schizophrenia (WASH-U-KSADS) mania and rapid cycling sections.
TLDR
The WASH-U-KSADS mania and rapid cycling sections have acceptable reliability and validity against parental and teacher reports were previously reported. Expand
Brain magnetic resonance imaging of structural abnormalities in bipolar disorder.
TLDR
Brain structural volumes were not significantly associated with duration of illness, prior medication exposure, number of previous hospital admissions, or duration of substance abuse, while the amygdala was enlarged in the patients. Expand
The functional neuroanatomy of bipolar disorder: a consensus model.
TLDR
A consensus model of the functional neuroanatomy of bipolar I disorder is developed based upon the participants' work as well as that of others to provide a potential substrate to guide future investigations and areas needing additional focus are identified. Expand
Ventricular and periventricular structural volumes in first- versus multiple-episode bipolar disorder.
TLDR
Lateral ventriculomegaly was greater in bipolar disorder patients who had had repeated manic episodes, but it does not appear to be secondary to small critical periventricular structures. Expand
Olanzapine versus placebo in the treatment of adolescents with bipolar mania.
TLDR
Olanzapine was effective in the treatment of bipolar mania in adolescent patients and patients treated with olanzapine had significantly greater weight gain and increases in the levels of hepatic enzymes, prolactin, fasting glucose, fasting total cholesterol, and uric acid. Expand
A double-blind, randomized, placebo-controlled study of quetiapine as adjunctive treatment for adolescent mania.
TLDR
It is indicated that quetiapine in combination with DVP is more effective for the treatment of adolescent bipolar mania than DVP alone and well tolerated. Expand
Magnetic resonance imaging analysis of amygdala and other subcortical brain regions in adolescents with bipolar disorder.
TLDR
This study evaluated brain regions that are thought to modulate mood utilizing quantitative analyses of thin-slice magnetic resonance imaging scans of adolescents with bipolar disorder to clarify the role of these brain regions in the neurophysiology of adolescent bipolar disorder. Expand
Voxel-Based Study of Structural Changes in First-Episode Patients with Bipolar Disorder
TLDR
Structural changes are absent from VLPFC early in the course of bipolar disorder, suggesting that dysfunctional neuronal proliferation or pruning may occur in bipolar patients. Expand
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