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zileuton

Known as: N-(1-benzo(b)thien-2-ylethyl)-N-hydroxyurea, (+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea, (+-)-N-Hydroxy-N-(1-benzo[b]thien-2-ylethyl)-urea 
A synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the… Expand
National Institutes of Health

Related topics

Related topics

17 relations
12 HR zileuton 600 MG Extended Release Oral Tablet [Zyflo]AsthmaBronchodilation [PE]CYP1A2 protein, human
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Narrower (3)

A 64077LeutrolZyflo

Broader (4)

Anti-Inflammatory Agents, Non-SteroidalLeukotriene AntagonistsLipoxygenase Inhibitorshydroxyurea

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
Ferroptosis: process and function
Ferroptosis is a recently recognized form of regulated cell death. It is characterized morphologically by the presence of smaller… Expand
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Review
2014
Review
2014
Acne is an inflammatory disease and alterations of sebum composition initiate acne lesions
Hyperseborrhoea has been considered as a major aetiopathogenetic factor of acne. However, changes in sebaceous gland activity not… Expand
Highly Cited
2011
Highly Cited
2011
Omalizumab in Severe Allergic Asthma Inadequately Controlled With Standard Therapy
BACKGROUND Inhaled corticosteroids (ICS) and long-acting β(2)-agonists (LABAs) are recommended in patients with asthma that is… Expand
Highly Cited
2010
Highly Cited
2010
The 5‐lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages
BACKGROUND AND PURPOSE Zileuton is the only 5‐lipoxygenase (5‐LOX) inhibitor marketed as a treatment for asthma, and is often… Expand
Highly Cited
1998
Highly Cited
1998
Benefits from adding the 5-lipoxygenase inhibitor zileuton to conventional therapy in aspirin-intolerant asthmatics.
From bronchoprovocation studies and investigations of the acute effects of drugs that inhibit leukotrienes (LT), the hypothesis… Expand
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Highly Cited
1997
Highly Cited
1997
Hydroxyurea dermopathy: a unique lichenoid eruption complicating long-term therapy with hydroxyurea.
BACKGROUND Hydroxyurea is usually a well tolerated antitumor agent. OBJECTIVE Our purpose was to describe a distinct clinical… Expand
Highly Cited
1996
Highly Cited
1996
Effect of treatment with zileuton, a 5-lipoxygenase inhibitor, in patients with asthma. A randomized controlled trial. Zileuton Clinical Trial Group.
OBJECTIVE To study the effect of 3 months of treatment with zileuton, an inhibitor of the enzymatic pathway (5-lipoxygenase… Expand
Highly Cited
1996
Highly Cited
1996
Effect of Treatment With Zileuton, a 5-Lipoxygenase Inhibitor, in Patients With Asthma: A Randomized Controlled Trial
Objective. —To study the effect of 3 months of treatment with zileuton, an inhibitor of the enzymatic pathway (5-lipoxygenase… Expand
Review
1993
Review
1993
The Effect of Inhibition of 5-Lipoxygenase by Zileuton in Mild-to-Moderate Asthma
Although intermittent episodic airway narrowing occurs in persons with asthma, the biochemical basis of this obstruction has not… Expand
Highly Cited
1991
Highly Cited
1991
5-lipoxygenase inhibitory activity of zileuton.
Zileuton [N-(1-benzo[b]thien-2-ylethyl)-N-hydroxyure] inhibited 5-hydroxyeicosatetraenoic acid synthesis by rat basophilic… Expand
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