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zileuton

Known as: N-(1-benzo(b)thien-2-ylethyl)-N-hydroxyurea, (+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea, (+-)-N-Hydroxy-N-(1-benzo[b]thien-2-ylethyl)-urea 
A synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the… 
National Institutes of Health

Related topics

Related topics

17 relations
12 HR zileuton 600 MG Extended Release Oral Tablet [Zyflo]AsthmaBronchodilation [PE]CYP1A2 protein, human

Narrower (3)

A 64077LeutrolZyflo

Broader (4)

Anti-Inflammatory Agents, Non-SteroidalLeukotriene AntagonistsLipoxygenase Inhibitorshydroxyurea

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Design, synthesis and evaluation of semi-synthetic triazole-containing caffeic acid analogues as 5-lipoxygenase inhibitors.
Highly Cited
2010
Highly Cited
2010
Impaired phagocytosis by alveolar macrophages from diabetic rats is related to the deficient coupling of LTs to the Fc gamma R signaling cascade.
1999
1999
Role of prostaglandin H synthase isoforms in murine ear edema induced by phorbol ester application on skin.
Highly Cited
1998
Highly Cited
1998
A Randomized Controlled Trial Comparing Zileuton With Theophylline in Moderate Asthma
Background: Zileuton, a leukotriene pathway inhibitor, was compared with slowly absorbed theophylline in a randomized, double… 
Review
1998
Review
1998
New approaches to anti-inflammatory therapy for asthma.
1998
1998
The role of platelet activating factor and other lipid mediators in inflammatory angiogenesis.
Highly Cited
1996
Highly Cited
1996
Acute and chronic effects of a 5-lipoxygenase inhibitor in asthma: a 6-month randomized multicenter trial. Zileuton Study Group.
BACKGROUND Leukotrienes produced by the 5-lipoxygenase pathway of arachidonic acid metabolism may mediate bronchoconstriction and… 
Review
1995
Review
1995
Clinical activity of leukotriene inhibitors.
1995
1995
Pharmacokinetics and Pharmacodynamics of Zileuton after Oral Administration of Single and Multiple Dose Regimens of Zileuton 600mg in Healthy Volunteers
SummaryThe pharmacokinetics and pharmacodynamics of zileuton were determined after oral administration of single dose (600mg) and… 
1991
1991
Pharmacokinetics, safety, and ability to diminish leukotriene synthesis by zileuton, an inhibitor of 5-lipoxygenase.
Zileuton is a potent and specific inhibitor of 5-lipoxygenase, the first dedicated enzyme in the metabolism of arachidonic acid… 
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