zileuton

Known as: N-(1-benzo(b)thien-2-ylethyl)-N-hydroxyurea, (+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea, (+-)-N-Hydroxy-N-(1-benzo[b]thien-2-ylethyl)-urea 
A synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the… (More)
National Institutes of Health

Related topics

Related topics

16 relations
12 HR zileuton 600 MG Extended Release Oral Tablet [Zyflo]AsthmaBronchodilation [PE]CYP1A2 protein, human
(More)

Narrower (3)

A 64077LeutrolZyflo

Broader (4)

Anti-Inflammatory Agents, Non-SteroidalLeukotriene AntagonistsLipoxygenase Inhibitorshydroxyurea

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Zileuton, a new efficient and safe systemic anti-acne drug.
Tissue inflammation is a major component of the acne process. Leukotriene B(4) (LTB(4)) is considered to be a major player in the… (More)
Is this relevant?
Review
2007
Review
2007
Zileuton: clinical implications of 5-Lipoxygenase inhibition in severe airway disease.
The 5-Lipoxygenase pathway results in the formation of leukotrienes, including leukotriene B(4) (LTB(4)), 5-oxo-6E,8Z,11Z,14Z… (More)
Is this relevant?
Highly Cited
2006
Highly Cited
2006
Augmentation of myocardial production of 15-epi-lipoxin-a4 by pioglitazone and atorvastatin in the rat.
BACKGROUND Both statins and thiazolidinediones have antiinflammatory properties. However, the exact mechanisms underlying these… (More)
  • figure 1
  • figure 2
  • figure 5
  • figure 3
  • figure 6
Is this relevant?
2005
2005
Zileuton, an oral 5-lipoxygenase inhibitor, directly reduces sebum production.
BACKGROUND Zileuton, a 5-lipoxygenase inhibitor, reduces the number of inflammatory lesions in moderate acne and inhibits the… (More)
  • table 1
Is this relevant?
2003
2003
Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, a 5-lipoxygenase inhibitor.
Zileuton, a 5-lipoxygenase inhibitor, was evaluated as an inhibitor of cytochrome P450 activity in human liver microsomes. In the… (More)
  • figure 1
  • table 1
  • figure 2
  • table 2
  • figure 3
Is this relevant?
Highly Cited
1998
Highly Cited
1998
Benefits from adding the 5-lipoxygenase inhibitor zileuton to conventional therapy in aspirin-intolerant asthmatics.
From bronchoprovocation studies and investigations of the acute effects of drugs that inhibit leukotrienes (LT), the hypothesis… (More)
  • table 1
  • table 2
  • figure 2
  • figure 1
  • figure 3
Is this relevant?
1993
1993
Effects of zileuton, a new 5-lipoxygenase inhibitor, in experimentally induced colitis in rats
The efficacy of zileuton, a new 5-lipoxygenase inhibitor, was investigated in comparison with sulphasalazine in an experimental… (More)
  • figure 1
  • figure 3
  • figure 2
  • table 1
  • table 2
Is this relevant?
Review
1992
Review
1992
The discovery and development of zileuton: an orally active 5-lipoxygenase inhibitor.
The enzyme 5-lipoxygenase is a key target in the effort to discover drugs which inhibit the pathophysiology associated with the… (More)
Is this relevant?
1992
1992
Zileuton, a 5-lipoxygenase inhibitor in rheumatoid arthritis.
The effects of zileuton, a new 5-lipoxygenase inhibitor, on leukotriene generation and clinical response in rheumatoid arthritis… (More)
Is this relevant?
Highly Cited
1991
Highly Cited
1991
5-lipoxygenase inhibitory activity of zileuton.
Zileuton [N-(1-benzo[b]thien-2-ylethyl)-N-hydroxyure] inhibited 5-hydroxyeicosatetraenoic acid synthesis by rat basophilic… (More)
Is this relevant?