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zileuton

Known as: N-(1-benzo(b)thien-2-ylethyl)-N-hydroxyurea, (+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea, (+-)-N-Hydroxy-N-(1-benzo[b]thien-2-ylethyl)-urea 
A synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the… 
National Institutes of Health

Papers overview

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Review
2016
Review
2016
Ferroptosis is a recently recognized form of regulated cell death. It is characterized morphologically by the presence of smaller… 
Highly Cited
2016
Highly Cited
2016
Highly Cited
2011
Highly Cited
2011
BACKGROUND Inhaled corticosteroids (ICS) and long-acting β(2)-agonists (LABAs) are recommended in patients with asthma that is… 
Review
2007
Review
2007
The 5‐Lipoxygenase pathway results in the formation of leukotrienes, including leukotriene B4 (LTB4), 5‐oxo‐6E,8Z,11Z,14Z… 
Highly Cited
1998
Highly Cited
1998
From bronchoprovocation studies and investigations of the acute effects of drugs that inhibit leukotrienes (LT), the hypothesis… 
Highly Cited
1996
Highly Cited
1996
OBJECTIVE To study the effect of 3 months of treatment with zileuton, an inhibitor of the enzymatic pathway (5-lipoxygenase… 
Review
1993
Review
1993
Although intermittent episodic airway narrowing occurs in persons with asthma, the biochemical basis of this obstruction has not… 
Highly Cited
1991
Highly Cited
1991
Zileuton [N-(1-benzo[b]thien-2-ylethyl)-N-hydroxyure] inhibited 5-hydroxyeicosatetraenoic acid synthesis by rat basophilic…