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zileuton

Known as: N-(1-benzo(b)thien-2-ylethyl)-N-hydroxyurea, (+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea, (+-)-N-Hydroxy-N-(1-benzo[b]thien-2-ylethyl)-urea 
A synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the… 
National Institutes of Health

Related topics

Related topics

17 relations
12 HR zileuton 600 MG Extended Release Oral Tablet [Zyflo]AsthmaBronchodilation [PE]CYP1A2 protein, human

Narrower (3)

A 64077LeutrolZyflo

Broader (4)

Anti-Inflammatory Agents, Non-SteroidalLeukotriene AntagonistsLipoxygenase Inhibitorshydroxyurea

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Impaired phagocytosis by alveolar macrophages from diabetic rats is related to the deficient coupling of LTs to the Fc gamma R signaling cascade.
2006
2006
Lipoxygenase-derived eicosanoids are involved in the inhibitory effect of Crotalus durissus terrificus venom or crotoxin on rat macrophage phagocytosis.
Highly Cited
2001
Highly Cited
2001
Acute effects of the cys-leukotriene-1 receptor antagonist, montelukast, on experimental colitis in rats.
Highly Cited
2000
Highly Cited
2000
Anti-inflammatory effects of zileuton in a subpopulation of allergic asthmatics.
The objective of this study was to determine the effects of allergen exposure on leukotriene generation and inflammation within… 
Highly Cited
1998
Highly Cited
1998
A Randomized Controlled Trial Comparing Zileuton With Theophylline in Moderate Asthma
Background: Zileuton, a leukotriene pathway inhibitor, was compared with slowly absorbed theophylline in a randomized, double… 
Review
1995
Review
1995
Clinical activity of leukotriene inhibitors.
1995
1995
Effect of Zileuton on Theophylline Pharmacokinetics
SummaryIn controlled trials involving asthma patients, zileuton — a selective 5-lipoxygenase inhibitor — has significantly… 
Highly Cited
1993
Highly Cited
1993
Effects of zileuton, a new 5-lipoxygenase inhibitor, in experimentally induced colitis in rats
The efficacy of zileuton, a new 5-lipoxygenase inhibitor, was investigated in comparison with sulphasalazine in an experimental… 
Review
1992
Review
1992
5-lipoxygenase inhibitors and their anti-inflammatory activities.
Highly Cited
1992
Highly Cited
1992
Zileuton, a 5-lipoxygenase inhibitor in rheumatoid arthritis.
The effects of zileuton, a new 5-lipoxygenase inhibitor, on leukotriene generation and clinical response in rheumatoid arthritis… 
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