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zileuton

Known as: N-(1-benzo(b)thien-2-ylethyl)-N-hydroxyurea, (+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea, (+-)-N-Hydroxy-N-(1-benzo[b]thien-2-ylethyl)-urea 
A synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the… 
National Institutes of Health

Related topics

Related topics

17 relations
12 HR zileuton 600 MG Extended Release Oral Tablet [Zyflo]AsthmaBronchodilation [PE]CYP1A2 protein, human

Narrower (3)

A 64077LeutrolZyflo

Broader (4)

Anti-Inflammatory Agents, Non-SteroidalLeukotriene AntagonistsLipoxygenase Inhibitorshydroxyurea

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
Ferroptosis: process and function
Ferroptosis is a recently recognized form of regulated cell death. It is characterized morphologically by the presence of smaller… 
Highly Cited
2016
Highly Cited
2016
Identification of ACSL4 as a biomarker and contributor of ferroptosis.
Highly Cited
2011
Highly Cited
2011
Omalizumab in Severe Allergic Asthma Inadequately Controlled With Standard Therapy
BACKGROUND Inhaled corticosteroids (ICS) and long-acting β(2)-agonists (LABAs) are recommended in patients with asthma that is… 
Review
2007
Review
2007
Zileuton: clinical implications of 5‐Lipoxygenase inhibition in severe airway disease
The 5‐Lipoxygenase pathway results in the formation of leukotrienes, including leukotriene B4 (LTB4), 5‐oxo‐6E,8Z,11Z,14Z… 
Highly Cited
2002
Highly Cited
2002
Hyperforin is a dual inhibitor of cyclooxygenase-1 and 5-lipoxygenase.
Highly Cited
1998
Highly Cited
1998
Benefits from adding the 5-lipoxygenase inhibitor zileuton to conventional therapy in aspirin-intolerant asthmatics.
From bronchoprovocation studies and investigations of the acute effects of drugs that inhibit leukotrienes (LT), the hypothesis… 
Highly Cited
1996
Highly Cited
1996
Effect of treatment with zileuton, a 5-lipoxygenase inhibitor, in patients with asthma. A randomized controlled trial. Zileuton Clinical Trial Group.
OBJECTIVE To study the effect of 3 months of treatment with zileuton, an inhibitor of the enzymatic pathway (5-lipoxygenase… 
Highly Cited
1996
Highly Cited
1996
Acute and chronic effects of a 5-lipoxygenase inhibitor in asthma: A 6-month randomized multicenter trial
Review
1993
Review
1993
The Effect of Inhibition of 5-Lipoxygenase by Zileuton in Mild-to-Moderate Asthma
Although intermittent episodic airway narrowing occurs in persons with asthma, the biochemical basis of this obstruction has not… 
Highly Cited
1991
Highly Cited
1991
5-lipoxygenase inhibitory activity of zileuton.
Zileuton [N-(1-benzo[b]thien-2-ylethyl)-N-hydroxyure] inhibited 5-hydroxyeicosatetraenoic acid synthesis by rat basophilic… 
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