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zileuton

Known as: N-(1-benzo(b)thien-2-ylethyl)-N-hydroxyurea, (+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea, (+-)-N-Hydroxy-N-(1-benzo[b]thien-2-ylethyl)-urea 
A synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the… 
National Institutes of Health

Related topics

Related topics

17 relations
12 HR zileuton 600 MG Extended Release Oral Tablet [Zyflo]AsthmaBronchodilation [PE]CYP1A2 protein, human

Narrower (3)

A 64077LeutrolZyflo

Broader (4)

Anti-Inflammatory Agents, Non-SteroidalLeukotriene AntagonistsLipoxygenase Inhibitorshydroxyurea

Papers overview

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2020
2020
Trombosis Berulang pada Pasien dengan Polisitemia Vera dan Penyakit Ginjal Kronis
Abstrak Polisitemia vera adalah kelainan mieloproliferatif dimana terjadi abnormalitas klonal yang melibatkan sel progenitor… 
Review
2016
Review
2016
INHIBITORS OF LEUKOTRIENES SYNTHESIS: NOVEL AGENTS AND THEIR IMPLEMENTATION.
Leukotrienes (LTs) belong to pro-inflammatory mediators that are biosynthesized from arachidonic acid (AA), inter alia, by 5… 
2015
2015
Montelukast As An Adjunct To Treatment of Chronic Rhinosinusitis With Polyposis: A Prospective Randomized Controlled Trial
In a prospective, randomized controlled trial, forty consecutive adult patients with bilateral nasal polyps were randomized into… 
2015
2015
The Possible Protective Effects of Zileuton against Pulmonary Fibrosis Induced by Amiodarone in Male Rats
Introduction Pulmonary fibrosis is characterized by cellular alteration of the alveolar region with lung inflammation… 
2013
2013
Monteleucast and Zileuton Retard the Progression of Atherosclerosis via Down Regulation of the Inflammatory and Oxidative Pathways
Background: Atherosclerosis and its thrombotic complications are responsible for remarkably high numbers of deaths. Leukotrines… 
2011
2011
Abstract 15501: The 5-Lipoxygenase Inhibitor Zileuton Improves Endothelial Function in Carriers of Coronary Heart Disease Risk Haplotypes in the ALOX5AP and LTA4H Leukotriene Pathway Genes
Background: Genome wide linkage studies have identified variants in the leukotriene synthesis pathway as conferring risk of… 
1996
1996
Azole phenoxy hydroxyureas as selective and orally active inhibitors of 5-lipoxygenase.
Azole phenoxy hydroxyureas are a new class of 5-lipoxygenase (5-LO) inhibitors. Structure-activity relationship studies have… 
1995
1995
Determination of a New 5-Lipoxygenase Inhibitor, Zileuton, and its Inactive N-Dehydroxylated Metabolite in Plasma by High Performance Liquid Chromatography
SummaryA rapid and sensitive assay was developed for the measurement of plasma concentrations of zileuton racemate, a potent… 
1994
1994
Second generation leukotriene biosynthesis inhibitors
Abstract 
1955
1955
Dämpfen von Rundholz.—Erste Mitteilung: Papierchromatographische Untersuchungen an Dämpfkondensaten von Rotbuche
l )ie Messungen haben vorers t or ient ierent len Charakter , (lie A1ost)Iutl)est{lmnung des Claromgehaltes erfi)rdert E ichung…