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zileuton

Known as: N-(1-benzo(b)thien-2-ylethyl)-N-hydroxyurea, (+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea, (+-)-N-Hydroxy-N-(1-benzo[b]thien-2-ylethyl)-urea 
A synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the… Expand
National Institutes of Health

Papers overview

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Review
2016
Review
2016
Ferroptosis is a recently recognized form of regulated cell death. It is characterized morphologically by the presence of smaller… Expand
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Review
2014
Review
2014
Hyperseborrhoea has been considered as a major aetiopathogenetic factor of acne. However, changes in sebaceous gland activity not… Expand
Highly Cited
2011
Highly Cited
2011
BACKGROUND Inhaled corticosteroids (ICS) and long-acting β(2)-agonists (LABAs) are recommended in patients with asthma that is… Expand
Highly Cited
2010
Highly Cited
2010
BACKGROUND AND PURPOSE Zileuton is the only 5‐lipoxygenase (5‐LOX) inhibitor marketed as a treatment for asthma, and is often… Expand
Highly Cited
1998
Highly Cited
1998
From bronchoprovocation studies and investigations of the acute effects of drugs that inhibit leukotrienes (LT), the hypothesis… Expand
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Highly Cited
1997
Highly Cited
1997
BACKGROUND Hydroxyurea is usually a well tolerated antitumor agent. OBJECTIVE Our purpose was to describe a distinct clinical… Expand
Highly Cited
1996
Highly Cited
1996
OBJECTIVE To study the effect of 3 months of treatment with zileuton, an inhibitor of the enzymatic pathway (5-lipoxygenase… Expand
Highly Cited
1996
Highly Cited
1996
Objective. —To study the effect of 3 months of treatment with zileuton, an inhibitor of the enzymatic pathway (5-lipoxygenase… Expand
Review
1993
Review
1993
Although intermittent episodic airway narrowing occurs in persons with asthma, the biochemical basis of this obstruction has not… Expand
Highly Cited
1991
Highly Cited
1991
Zileuton [N-(1-benzo[b]thien-2-ylethyl)-N-hydroxyure] inhibited 5-hydroxyeicosatetraenoic acid synthesis by rat basophilic… Expand