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zileuton

Known as: N-(1-benzo(b)thien-2-ylethyl)-N-hydroxyurea, (+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea, (+-)-N-Hydroxy-N-(1-benzo[b]thien-2-ylethyl)-urea 
A synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the… 
National Institutes of Health

Papers overview

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Highly Cited
1998
Highly Cited
1998
Background: Zileuton, a leukotriene pathway inhibitor, was compared with slowly absorbed theophylline in a randomized, double… 
Highly Cited
1996
Highly Cited
1996
BACKGROUND Leukotrienes produced by the 5-lipoxygenase pathway of arachidonic acid metabolism may mediate bronchoconstriction and… 
1995
1995
SummaryThe pharmacokinetics and pharmacodynamics of zileuton were determined after oral administration of single dose (600mg) and… 
1991
1991
Zileuton is a potent and specific inhibitor of 5-lipoxygenase, the first dedicated enzyme in the metabolism of arachidonic acid…