hydroxyurea

Known as: Carbamoyl Oxime, Carbamohydroximic Acid, Hydroxycarbamid 
A monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme… (More)
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Stroke is a devastating complication of sickle cell anemia (SCA) with high recurrence if untreated. Chronic transfusions reduce… (More)
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Highly Cited
2010
Highly Cited
2010
Faithful DNA replication is essential to all life. Hydroxyurea (HU) depletes the cells of dNTPs, which initially results in… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND We conducted a randomized comparison of hydroxyurea with anagrelide in the treatment of essential thrombocythemia… (More)
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Highly Cited
2004
Highly Cited
2004
Hydroxyurea improves hematologic parameters for children with sickle cell disease (SCD), but its long-term efficacy at maximum… (More)
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Highly Cited
2003
Highly Cited
2003
CONTEXT Hydroxyurea increases levels of fetal hemoglobin (HbF) and decreases morbidity from vaso-occlusive complications in… (More)
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Highly Cited
1999
Highly Cited
1999
PURPOSE In 1986, a protocol comparing primary radiation therapy (RT) plus hydroxyurea (HU) to irradiation plus fluorouracil (5-FU… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND AND METHODS On behalf of the Gynecologic Oncology Group, we performed a randomized trial of radiotherapy in… (More)
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Highly Cited
1999
Highly Cited
1999
Previous studies have determined the short-term toxicity profile, laboratory changes, and clinical efficacy associated with… (More)
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Highly Cited
1995
Highly Cited
1995
BACKGROUND In a previous open-label study of hydroxyurea therapy, the synthesis of fetal hemoglobin increased in most patients… (More)
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Review
1992
Review
1992
Hydroxyurea is well absorbed after oral administration, converted to a free radical nitroxide in vivo, and transported by… (More)
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