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hydroxyurea

Known as: Carbamoyl Oxime, Carbamohydroximic Acid, Hydroxycarbamid 
A monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme… 
National Institutes of Health

Related topics

Related topics

45 relations

Narrower (12)

A 78773HydreaL-6 protocolOnco-carbide

Broader (3)

Antineoplastic AgentsEnzyme Inhibitorssickling inhibitor
DNA Repair InhibitionDNA Synthesis InhibitionHead and Neck NeoplasmsIn Blood

Papers overview

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Review
2013
Review
2013
A global view of health--an unfolding series.
This issue of the Journal includes the first article in a series of review articles on global health.1 In a journal that proudly… 
2003
2003
Fatal myelodysplastic syndrome developing during therapy with imatinib mesylate and characterised by the emergence of complex Philadelphia negative clones
Fatal myelodysplastic syndrome developing during therapy with imatinib mesylate and characterised by the emergence of complex… 
Highly Cited
1999
Highly Cited
1999
HDS, HDN and HYD activities and temperature‐programmed reduction of unsupported transition metal sulfides
Several transition metal sulfides have been shown to exhibit high catalytic activities in various hydrotreating reactions. The… 
Highly Cited
1985
Highly Cited
1985
Increased gene amplification in L5178Y mouse lymphoma cells with hydroxyurea-induced chromosomal aberrations.
Chromosomal aberrations and dihydrofolate reductase gene amplification are observed in L5178Y mouse lymphoma cells after… 
1971
1971
Immune cytolysis in relation to the growth cycle of Chinese hamster cells.
Summary The colony-forming ability of Chinese hamster cells was used to study the immune damage mediated by heterologous… 
Highly Cited
1968
Highly Cited
1968
The combined effect of hydroxyurea and x-rays on Chinese hamster cells in vitro.
Summary Hydroxyurea inhibits DNA synthesis in Chinese hamster cells and is selectively toxic for cells actually in DNA synthesis… 
Highly Cited
1968
Highly Cited
1968
Further studies on the mechanism of action of hydroxyurea.
Summary Addition of the four deoxyribonucleosides in vitro to 6C3HED mouse ascites tumor stimulates 32 P incorporation into DNA… 
1967
1967
Metabolic effects of hydroxyurea on BHK-21 cells transformed with polyoma virus.
Summary Hydroxyurea interferes with the DNA metabolism of BHK-21 cells transformed by polyoma virus. The syntheses of RNA and… 
Highly Cited
1965
Highly Cited
1965
Induction of chromosome breaks in cultured normal human leukocytes by potassium arsenite, hydroxyurea and related compounds.
Summary Hydroxyurea and N -hydroxyurethane at mm concentrations produced a high incidence of chromosome breaks along with other… 
1965
1965
HYDROXYUREA ADMINISTERED INTERMITTENTLY.
THE SYNTHESIS of hydroxyurea (Hydrea) was reported in 1869 by Dresler and Stein. 1 In animal studies, Rosenthal et al 2 found… 
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