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hydroxyurea

Known as: Carbamoyl Oxime, Carbamohydroximic Acid, Hydroxycarbamid 
A monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme… Expand
National Institutes of Health

Papers overview

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Review
2019
Review
2019
Disease Overview: Polycythemia vera (PV) and essential thrombocythemia (ET) are myeloproliferative neoplasms respectively… Expand
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Review
2018
Review
2018
For over 100 years, clinicians and scientists have been unravelling the consequences of the A to T substitution in the β-globin… Expand
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Review
2017
Review
2017
Acute chest syndrome (ACS) is a frequent cause of acute lung disease in children with sickle cell disease (SCD). Patients may… Expand
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Highly Cited
2010
Highly Cited
2010
Summary Faithful DNA replication is essential to all life. Hydroxyurea (HU) depletes the cells of dNTPs, which initially results… Expand
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Highly Cited
2005
Highly Cited
2005
BACKGROUND We conducted a randomized comparison of hydroxyurea with anagrelide in the treatment of essential thrombocythemia… Expand
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Highly Cited
1995
Highly Cited
1995
BACKGROUND In a previous open-label study of hydroxyurea therapy, the synthesis of fetal hemoglobin increased in most patients… Expand
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Highly Cited
1995
Highly Cited
1995
BACKGROUND Abnormalities in the number and function of platelets may contribute to thromboembolic complications in patients with… Expand
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Review
1992
Review
1992
  • J. Yarbro
  • Seminars in oncology
  • 1992
  • Corpus ID: 26793903
Hydroxyurea is well absorbed after oral administration, converted to a free radical nitroxide in vivo, and transported by… Expand
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Highly Cited
1984
Highly Cited
1984
Hydroxyurea, a widely used cytotoxic/cytostatic agent that does not influence methylation of DNA bases, increases fetal… Expand
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Highly Cited
1968
Highly Cited
1968
Hydroxyurea, a compound which inhibits the growth of rapidly proliferating tissues in animals and man, is known to inhibit DNA… Expand
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