Skip to search formSkip to main contentSkip to account menu

hydroxyurea

Known as: Carbamoyl Oxime, Carbamohydroximic Acid, Hydroxycarbamid 
A monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme… 
National Institutes of Health

Related topics

Related topics

45 relations

Narrower (12)

A 78773HydreaL-6 protocolOnco-carbide

Broader (3)

Antineoplastic AgentsEnzyme Inhibitorssickling inhibitor
DNA Repair InhibitionDNA Synthesis InhibitionHead and Neck NeoplasmsIn Blood

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1993
Highly Cited
1993
The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2.
The substrate specificity of mitogen-activated protein (MAP) kinase-activated protein kinase-2 (MAPKAP kinase-2) was investigated… 
Highly Cited
1985
Highly Cited
1985
Subunit M2 of mammalian ribonucleotide reductase. Characterization of a homogeneous protein isolated from M2-overproducing mouse cells.
Highly Cited
1983
Highly Cited
1983
Enhancement of methotrexate resistance and dihydrofolate reductase gene amplification by treatment of mouse 3T6 cells with hydroxyurea
We investigated various parameters associated with the initial selection of mouse 3T6 cells for resistance to single… 
Highly Cited
1979
Highly Cited
1979
Correlation between cell cycle duration and RNA content
The metachromatic fluorochrome acridine orange was used to differentially stain DNA and RNA in Chinese hamster ovary (CHO) cells… 
Highly Cited
1976
Highly Cited
1976
A significant lag in the induction of ovalbumin messenger RNA by steroid hormones: A receptor translocation hypothesis
Highly Cited
1975
Highly Cited
1975
Molecular Mechanisms for Repair of DNA
Methylating agents may produce as many as nine alkylated purine and pyrimidine adducts in DNA, as well as forming… 
Highly Cited
1975
Highly Cited
1975
Nuclear DNA polymerases and the HeLa cell cycle.
Highly Cited
1974
Highly Cited
1974
Histones and histone synthesis in sea urchin development.
Highly Cited
1971
Highly Cited
1971
Effects of hydroxyurea and 1-beta-D-arabinofuranosyl-cytosine on deoxyribonucleotide pools in mouse embryo cells.
Mouse embryo cells incubated in medium with 0.5% serum contain only few cells which synthesize DNA. When the serum concentration… 
Highly Cited
1971
Highly Cited
1971
Quantitative aspects of the repair of alkylated DNA in cultured mammalian cells. II. Non-semiconservative DNA synthesis ('repair synthesis') in HeLa and Chinese hamster cells following treatment with…
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)