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hydroxyurea

Known as: Carbamoyl Oxime, Carbamohydroximic Acid, Hydroxycarbamid 
A monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme… 
National Institutes of Health

Related topics

Related topics

45 relations

Narrower (12)

A 78773HydreaL-6 protocolOnco-carbide

Broader (3)

Antineoplastic AgentsEnzyme Inhibitorssickling inhibitor
DNA Repair InhibitionDNA Synthesis InhibitionHead and Neck NeoplasmsIn Blood

Papers overview

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Review
2013
Review
2013
A global view of health--an unfolding series.
This issue of the Journal includes the first article in a series of review articles on global health.1 In a journal that proudly… 
2003
2003
Fatal myelodysplastic syndrome developing during therapy with imatinib mesylate and characterised by the emergence of complex Philadelphia negative clones
Fatal myelodysplastic syndrome developing during therapy with imatinib mesylate and characterised by the emergence of complex… 
Highly Cited
1999
Highly Cited
1999
HDS, HDN and HYD activities and temperature‐programmed reduction of unsupported transition metal sulfides
Several transition metal sulfides have been shown to exhibit high catalytic activities in various hydrotreating reactions. The… 
1993
1993
Water perturbation close to non-polar groups in aqueous solutions
Abstract 
1977
1977
THE EFFECT OF A SINGLE INJECTION OF HYDROXYUREA ON CELL POPULATION KINETICS IN THE SMALL BOWEL MUCOSA OF THE RAT
The effect of a single injection of hydroxyurea (HU) on cell population kinetics in the jejunal crypt of the rat was studied… 
Highly Cited
1969
Highly Cited
1969
The effects of ferrous ion and dithioerythritol on inhibition by hydroxyruea of ribonucleotide reductase.
Inhibition by hydroxyurea of partially purified ribonucleotide reductase from rat tumor was studied in vitro . The inhibition was… 
Highly Cited
1968
Highly Cited
1968
Further studies on the mechanism of action of hydroxyurea.
Summary Addition of the four deoxyribonucleosides in vitro to 6C3HED mouse ascites tumor stimulates 32 P incorporation into DNA… 
1967
1967
Chromosome changes in embryos treated with various teratogens.
The association of chromosome changes with certain syndromes of congenital malformations has raised new questions as to the… 
1967
1967
Metabolic effects of hydroxyurea on BHK-21 cells transformed with polyoma virus.
Summary Hydroxyurea interferes with the DNA metabolism of BHK-21 cells transformed by polyoma virus. The syntheses of RNA and… 
1965
1965
HYDROXYUREA ADMINISTERED INTERMITTENTLY.
THE SYNTHESIS of hydroxyurea (Hydrea) was reported in 1869 by Dresler and Stein. 1 In animal studies, Rosenthal et al 2 found…