Zyflo

OBJECTIVE Maximum time of the effect of antileukotriene substances - Zileuton in the treatment of patients with bronchial asthma… (More)

5-lipoxygenase (5-LO) is a key enzyme in the synthesis of leukotrienes and 5-Oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (oxoETE… (More)

Inflammatory mediators and drugs which affect inflammation can influence the healing of injured tissues. Leukotrienes are potent… (More)

BACKGROUND A controlled-release (CR) formulation of zileuton was developed to simplify administration from 600 mg 4 times daily… (More)

increased substantially in recent years; between 1980 and 1993, the number of Americans affected by asthma increased more than… (More)

Selective inhibition of eicosanoid synthesis is thought to have effects on carcinogenesis in lung and colon cancer. However, it… (More)

BACKGROUND/AIMS Selective inhibition of eicosanoid synthesis decreases inflammation, however, it is still unknown whether… (More)

Leukotrienes are synthesized by different cells, including eosinophils, neutrophils, basophils, lymphocytes, macrophages, and… (More)

An impurity observed during the synthesis of zileuton (Zyflo) has been isolated and characterized as a benzo[b]thiophene… (More)

Asthma is a complex syndrome characterized by variable obstruction to airflow, bronchial hyperresponsiveness, and inflammation… (More)