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Leukotriene Antagonists

Known as: inhibitors leukotriene receptor, Leukotriene Receptor Antagonists, leukotriene antagonist 
A class of drugs designed to prevent leukotriene synthesis or activity by blocking binding at the receptor level.
National Institutes of Health

Related topics

Related topics

20 relations

Broader (1)

Anti-Asthmatic Agents

Narrower (14)

FPL 55712L 648051L 649923LY 171883
In BloodLeukotriene Receptor Antagonist [EPC]aspects of radiation effectschemical synthesis

Papers overview

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1989
1989
Leukotriene C4 and B4 in bronchoalveolar lavage fluid during biphasic allergic bronchoconstriction in sheep.
To study the contribution of leukotriene C4 (LTC4), leukotriene D4 (LTD4), leukotriene B4 (LTB4), and inflammation to the antigen… 
1987
1987
Leukotriene receptor antagonists. 2. The [[(tetrazol-5-ylaryl)oxy]methyl]acetophenone derivatives.
A series of [[(tetrazol-5-ylaryl)oxy]methyl]acetophenones was synthesized and evaluated as antagonists of leukotriene D4 induced… 
1986
1986
Enhancement of plasma levels of biologically active leukotriene B compounds during anaphylaxis in guinea pigs pretreated by indomethacin or by a fish oil-enriched diet.
The changes in arterial plasma concentrations of immunoreactive leukotriene B (LTB) were compared after antigen challenge of two… 
1986
1986
Synthesis and structure-activity relationship studies of a series of 5-aryl-4,6-dithianonanedioic acids and related compounds: a novel class of leukotriene antagonists.
A series of 5-alkynyl- and 5-aryl-4,6-dithianonanedioic acids and related compounds has been prepared for evaluation of… 
1986
1986
L-648,051, sodium 4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)- propylsulfonyl]-gamma-oxo-benzenebutanoate: a leukotriene D4 receptor antagonist.
L-648,051, sodium 4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy) propylsulfonyl]-gamma-oxo-benzenebutanoate is a selective and… 
1985
1985
Inhibition of human basophil leukotriene release by antiinflammatory steroids.
We have previously shown that 24-hour culture of human basophils with the antiinflammatory steroid dexamethasone produces an… 
Review
1985
Review
1985
Eicosanoids as mediators of ischemia and shock.
A variety of eicosanoids are produced in ischemic and circulatory shock. Many of these constrict arteries, induce platelet… 
1984
1984
Altered Coronary Vascular Responsiveness to Leukotrienes In Alloxan‐Diabetic Rats
Altered responsiveness to and metabolism of various eicosanoids in diabetic animals and patients has been reported by several… 
1982
1982
Comparative bronchoconstrictor effects of histamine, leukotriene C, and leukotriene D in normal human volunteers.
Highly Cited
1981
Highly Cited
1981
Radioimmunoassay of the leukotrienes of slow reacting substance of anaphylaxis.
A rabbit immunized with a conjugate of leukotriene D4 (LTD4) and bovine albumin via the icosanoid carboxyl produced antibodies…