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Leukotriene Antagonists

Known as: inhibitors leukotriene receptor, Leukotriene Receptor Antagonists, leukotriene antagonist 
A class of drugs designed to prevent leukotriene synthesis or activity by blocking binding at the receptor level.
National Institutes of Health

Related topics

Related topics

20 relations

Broader (1)

Anti-Asthmatic Agents

Narrower (14)

FPL 55712L 648051L 649923LY 171883
In BloodLeukotriene Receptor Antagonist [EPC]aspects of radiation effectschemical synthesis

Papers overview

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Review
2010
Review
2010
Airway remodelling in asthma: from benchside to clinical practice.
Airway remodelling refers to the structural changes that occur in both large and small airways relevant to miscellaneous diseases… 
Highly Cited
2009
Highly Cited
2009
Th17 Immunity in Patients with Allergic Asthma
Background: Allergic asthma is an inflammatory disease regulated by the T helper (Th) cells. The Th1/Th2 imbalance has been well… 
Highly Cited
2002
Highly Cited
2002
FunctionsIL-10, Which Down-Regulates Dendritic Cell Enhances the Production of Endogenous 2 Cyclooxygenase-2-Issued Prostaglandin E
PGE 2 is a well-known immunomodulator produced in the immune response by APCs, such as dendritic cells (DCs), the most potent APC… 
Highly Cited
1999
Highly Cited
1999
NO in exhaled air of asthmatic children is reduced by the leukotriene receptor antagonist montelukast.
Nitric oxide in exhaled air (FENO) is increased in asthmatic children, probably reflecting aspects of airway inflammation. We… 
Highly Cited
1998
Highly Cited
1998
Montelukast, a once-daily leukotriene receptor antagonist, in the treatment of chronic asthma: a multicenter, randomized, double-blind trial. Montelukast Clinical Research Study Group.
OBJECTIVES To determine the clinical effect of oral montelukast sodium, a leukotriene receptor antagonist, in asthmatic patients… 
Highly Cited
1998
Highly Cited
1998
Effects of LTD4 on human airway smooth muscle cell proliferation, matrix expression, and contraction In vitro: differential sensitivity to cysteinyl leukotriene receptor antagonists.
The cysteinyl leukotrienes (CysLTs) mimic many of the features of asthma and are implicated in its pathophysiology. Little… 
Review
1998
Review
1998
Efficacy of inhaled corticosteroids in asthma.
Highly Cited
1994
Highly Cited
1994
Effect of oral prednisone on airway inflammatory mediators in atopic asthma.
The mechanism of steroid action in asthma is unknown. Because steroids have effects in vitro on eicosanoid synthesis, we… 
Highly Cited
1991
Highly Cited
1991
Urinary leukotriene E4 concentrations increase after aspirin challenge in aspirin-sensitive asthmatic subjects.
Urinary leukotriene E4 (LTE4) concentrations have been measured in six asthmatic patients with aspirin sensitivity and in five… 
Highly Cited
1990
Highly Cited
1990
MK886, a potent and specific leukotriene biosynthesis inhibitor blocks and reverses the membrane association of 5-lipoxygenase in ionophore-challenged leukocytes.
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