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The monastery of Homblières, after 949, when it was turned from a community of nuns into a reformed Benedictine monastery under… Expand Asthma is a chronic inflammatory disease that is associated with widespread but variable airflow obstruction. The mechanisms that… Expand Substance P (SP) has been shown to mediate granulocyte infiltration into the mouse skin by inducing mast cell degranulation. In… Expand This study was designed to characterize the role of arachidonate 5-lipoxygenase metabolism during experimental intestinal… Expand BAY X 1005 ((R)-2-[4-(quinolin-2-yl-methoxy)phenyl]-2-cyclopentyl acetic acid) has been demonstrated to be a potent inhibitor of… Expand It has been suggested that the oxidative modification of low density lipoprotein (LDL) is a key event in atherogenesis. Several… Expand The effect of a single oral dose (800 mg) of zileuton (A-64077), a specific 5-lipoxygenase inhibitor, on the early and late… Expand BACKGROUND
The enzyme 5-lipoxygenase catalyzes the metabolism of arachidonic acid to form products that have been implicated in… Expand BACKGROUND AND METHODS
The clinical importance of leukotrienes in human allergy has not been defined, in part because there have… Expand Leukotriene B4 (LTB4) and prostaglandin E2 (PGE2) concentrations were measured in rectal dialysis fluid from ten patients with… Expand